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The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma

Lookup NU author(s): Dr Adrian Frank, Roberto Hernan, Dr Janet Lindsey, Dr Meryl Lusher, Professor Steven Clifford, Dr Richard Gilbertson

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Abstract

We analyzed the TP53 and INK4A/ARF loci in 29 pediatric medulloblastomas. Mutually exclusive mutation in TP53, methylation of P14(ARF) or deletion of INK4A/ARF were identified in 21% (6/29) of tumors. Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with significant anaplasia. Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma. (C) 2004 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Frank AJ, Hernan R, Hollander A, Lindsey JC, Lusher ME, Fuller CE, Clifford SC, Gilbertson RJ

Publication type: Article

Publication status: Published

Journal: Molecular Brain Research

Year: 2004

Volume: 121

Issue: 1-2

Pages: 137-140

ISSN (print): 0169-328X

ISSN (electronic): 1872-6941

URL: http://dx.doi.org/10.1016/j.molbrainres.2003.11.016

DOI: 10.1016/j.molbrainres.2003.11.016

PubMed id: 14969745


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