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Lookup NU author(s): Dr Adrian Frank,
Dr Janet Lindsey,
Dr Meryl Lusher,
Professor Steven Clifford,
Dr Richard Gilbertson
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We analyzed the TP53 and INK4A/ARF loci in 29 pediatric medulloblastomas. Mutually exclusive mutation in TP53, methylation of P14(ARF) or deletion of INK4A/ARF were identified in 21% (6/29) of tumors. Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with significant anaplasia. Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma. (C) 2004 Elsevier B.V. All rights reserved.
Author(s): Frank AJ, Hernan R, Hollander A, Lindsey JC, Lusher ME, Fuller CE, Clifford SC, Gilbertson RJ
Publication type: Article
Publication status: Published
Journal: Molecular Brain Research
ISSN (print): 0169-328X
ISSN (electronic): 1872-6941
PubMed id: 14969745
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