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Design, synthesis and initial in vitro evaluation of novel prodrugs for the treatment of cystinosis

Lookup NU author(s): Marian Case, Dr Andrew Hall, Dr Linda Hogarth, Amanda Jones

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Abstract

Simple amino acid prodrugs of cysteamine and cystamine were synthesized to overcome the problems of palatability and gastrointestinal irritation, while gamma-glutamyl prodrugs were synthesized to target the parent drug to gamma-glutamyl transpepticlase (GGT). Preliminary cystine-depleting evaluation in vitro suggests further investigation is warranted. Low toxicity of the prodrugs was observed.

Publication metadata

Author(s): Anderson RJ, Cairns D, Cardwell WA, Case MC, Groundwater PW, Hall AG, Hogarth LA, Jones AL, Meth-Cohn O, Suryadevara P, Tindall A, Thoene JG

Publication type: Article

Publication status: Published

Journal: Letters in Drug Design & Discovery

Year: 2006

Volume: 3

Issue: 5

Pages: 336-345

ISSN (print): 1570-1808

ISSN (electronic): 1875-628X

URL: http://dx.doi.org/10.2174/157018006777574258

DOI: 10.2174/157018006777574258

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