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Browsing publications by Dr Helen Tuppen

Newcastle AuthorsTitleYearFull text
Dr Claire McDonald
Matt Birkbeck
Dr Silvia Del Din
Professor Grainne Gorman
Dr Kieren Hollingsworth
et al.		Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study2025
Julie Faitg
Tracey Davey
Ross Laws
Dr Conor Lawless
Dr Helen Tuppen
et al.		Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease2025
Dr Helen Tuppen
Dr Claire Troakes
Dr Christopher Morris
Dr Joanna Elson
Dr Ilse Pienaar
Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes2025
Dr Claire McDonald
Matt Birkbeck
Dr Silvia Del Din
Dr Gráinne Gorman
Dr Kieren Hollingsworth
et al.		A study protocol to investigate if Acipimox improves muscle function and sarcopenia –an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community dwelling older adults.2024
Dan Hipps
Dr Angela Pyle
Dr Anna Porter
Philip Dobson
Dr Helen Tuppen
et al.		Variant load of mitochondrial DNA in single human mesenchymal stem cells2024
Dr Helen Tuppen
Dr Amy Reeve
Dr Amy Vincent
Single Cell Analysis of Mitochondrial DNA Deletions2023
Dr Alaa Abouhajar
Dr Lisa Alcock
Dr Theophile Bigirumurame
Penny Bradley
Laura Brown
et al.		Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy2022
Dr Diana Lehmann
Dr Helen Tuppen
Georgia Campbell
Charlotte Alston
Dr Conor Lawless
et al.		Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level2019
Dr Mariana Rocha
Hannah Rosa
Dr John Grady
Dr Langping He
Jane Newman
et al.		Pathological mechanisms underlying single large-scale mitochondrial DNA deletions2018
Dr Karolina Rygiel
Dr Helen Tuppen
Dr John Grady
Dr Amy Vincent
Dr Amy Reeve
et al.		Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis2016
Dr Helen Tuppen
Professor Robert Taylor
Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations2016
Dr Louise Hyslop
Dr Lyndsey Butterworth
Mahdi Lamb
Dr Nilendran Prathalingam
Qi Zhang
et al.		Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease2016
Dr Helen Tuppen
Professor Robert Taylor
A novel mitochondrial DNA m.7507A > G mutation is only pathogenic at high levels of heteroplasmy2015
Professor Grainne Gorman
Dr Hue Hornig - Do
Dr Helen Tuppen
Professor Laura Greaves
Dr Langping He
et al.		Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression2015
Dr Diana Lehmann
Dr Steven Hardy
Dr Helen Tuppen
Karen Baty
Professor Robert Taylor
Pathogenic mitochondrial mt-tRNAAla variants are uniquely associated with isolated myopathy2015
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