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Browsing publications by Dr Nichola Lax.

Newcastle AuthorsTitleYearFull text
Chris Hatton
Dr Amy Reeve
Dr Nichola Lax
Dr Alasdair Blain
Dr Yi Ng
et al.
Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies2020
Dr Daniel Erskine
Dr Amy Reeve
Dr Tuomo Polvikoski
Dr Andrew Schaefer
Professor Robert Taylor
et al.
Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls2020
Dr Hannah Hayhurst
Maria Anagnostou
Helen Bogle
Dr John Grady
Professor Robert Taylor
et al.
Dissecting the neuronal vulnerability underpinning Alpers' syndrome: A clinical and neuropathological study2019
Dr Nichola Lax
Shuna Whyte
Dr Alistair Jenkins
Emeritus Professor Doug Turnbull
Mark Cunningham
et al.
The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction2019
Dr Yi Ng
Dr Nichola Lax
Dr Charlotte Alston
Philippa Hepplewhite
Professor Patrick Chinnery
et al.
MT-ND5 Mutation Exhibits Highly Variable Neurological Manifestations at Low Mutant Load2018
Dr Kyle Thompson
Dr Monika Olahova
Dr Filippo Scialo
Dr Nichola Lax
Dr Fiona Robertson
et al.
OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect2018
Dr Nichola Lax
Professor Grainne Gorman
Emeritus Professor Doug Turnbull
Central nervous system involvement in mitochondrial disease2017
Dr Charlotte Alston
Dr Mariana Rocha
Dr Nichola Lax
Emeritus Professor Doug Turnbull
Professor Robert Taylor
et al.
The genetics and pathology of mitochondrial disease2017
Dr Ahmad Khundakar
Dr Peter Hanson
Dr Daniel Erskine
Dr Nichola Lax
Evangelia Karyka
et al.
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations2016
Jonathan Phillips
Dr Alex Laude
Professor Robert Lightowlers
Dr Christopher Morris
Emeritus Professor Doug Turnbull
et al.
Development of passive CLARITY and immunofluorescent labelling of multiple proteins in human cerebellum: understanding mechanisms of neurodegeneration in mitochondrial disease2016
Dr Nichola Lax
Dr John Grady
Dr Alex Laude
Felix Chan
Philippa Hepplewhite
et al.
Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease2016
Alexia Chrysostomou
Dr John Grady
Dr Alex Laude
Professor Robert Taylor
Emeritus Professor Doug Turnbull
et al.
Investigating complex I deficiency in Purkinje cells and synapses in patients with mitochondrial disease2016
Jonathan Phillips
Dr Hannah Hayhurst
Dr Nichola Lax
Neurodegeneration in mitochondrial disorders2016
Felix Chan
Dr Nichola Lax
Emeritus Professor Doug Turnbull
Professor Mark Cunningham
Neuronal oscillations: a physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?2016
Dr Yi Ng
Dr John Grady
Dr Nichola Lax
Dr John Bourke
Dr Charlotte Alston
et al.
Sudden adult death syndrome in m.3243A>G-related mitochondrial disease: an unrecognized clinical entity in young, asymptomatic adults2016
Professor Roger Whittaker
Professor Grainne Gorman
Dr Andrew Schaefer
Professor Rita Horvath
Dr Yi Ng
et al.
Epilepsy in Adults With Mitochondrial Disease: A Cohort Study2015
Dr Nichola Lax
Dr Langping He
Gavin Falkous
Professor Bobby McFarland
Professor Robert Taylor
et al.
Neuropathologic Characterization of Pontocerebellar Hypoplasia Type 6 Associated With Cardiomyopathy and Hydrops Fetalis and Severe Multisystem Respiratory Chain Deficiency due to Novel RARS2 Mutations2015
Dr Anne Grunewald
Dr Nichola Lax
Dr Amy Reeve
Philippa Hepplewhite
Karolina Rygiel
et al.
Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue2014
Dr Yi Ng
Dr Nichola Lax
Dr Andrew Schaefer
Professor Robert Taylor
Emeritus Professor Doug Turnbull
et al.
Sudden Unexpected Death in Adults with M.3243A>G Mutation2014
Dr Nichola Lax
Dr Charlotte Alston
Dr Tuomo Polvikoski
Dr Evelyn Jaros
Dr John Yarham
et al.
Early-Onset Cataracts, Spastic Paraparesis, and Ataxia Caused by a Novel Mitochondrial tRNA(Glu) (MT-TE) Gene Mutation Causing Severe Complex I Deficiency: A Clinical, Molecular, and Neuropathologic Study2013
Helen Bogle
Dr Nichola Lax
Dr Evelyn Jaros
Professor Bobby McFarland
Professor Robert Taylor
et al.
Neuropathological changes in Alpers' syndrome2013
Dr Amy Reeve
Dr Martin Meagher
Dr Nichola Lax
Dr Eve Cosgrave
Philippa Hepplewhite
et al.
The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons2013
Dr Nichola Lax
Philippa Hepplewhite
Dr Amy Reeve
Dr Victoria Nesbitt
Professor Bobby McFarland
et al.
Cerebellar Ataxia in Patients With Mitochondrial DNA Disease: A Molecular Clinicopathological Study2012
Dr Nichola Lax
Graham Campbell
Dr Amy Reeve
Jessica Zambonin
Professor Robert Taylor
et al.
Loss of Myelin-Associated Glycoprotein in Kearns-Sayre Syndrome2012
Dr Nichola Lax
Dr Ilse Pienaar
Dr Amy Reeve
Philippa Hepplewhite
Dr Evelyn Jaros
et al.
Microangiopathy in the cerebellum of patients with mitochondrial DNA disease2012
Dr Nichola Lax
Emeritus Professor Doug Turnbull
Mitochondrial allostatic load? The combined effect of glucose intolerance and mitochondrial DNA mutations on the incidence of neurological symptoms2012
Dr Nichola Lax
Dr Evelyn Jaros
Neurodegeneration in primary mitochondrial disorders2012
Dr Amy Reeve
Tae-Kyung Park
Dr Evelyn Jaros
Graham Campbell
Dr Nichola Lax
et al.
Relationship Between Mitochondria and α-Synuclein: A Study of Single Substantia Nigra Neurons2012
Dr Nichola Lax
Professor Roger Whittaker
Philippa Hepplewhite
Dr Amy Reeve
Dr Evelyn Jaros
et al.
Sensory neuronopathy in patients harbouring recessive polymerase γ mutations2012
Dr Nichola Lax
Emeritus Professor Doug Turnbull
Dr Amy Reeve
Mitochondrial mutations: newly discovered players in neuronal degeneration2011
Dr Nichola Lax
Dr Daria Diodato
Emeritus Professor Doug Turnbull
The mitochondrial brain: From mitochondrial genome to neurodegeneration2010
Dr Don Mahad
Dr Iryna Ziabreva
Graham Campbell
Dr Nichola Lax
Dr Kathryn White
et al.
Mitochondrial changes within axons in multiple sclerosis2009