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Browsing publications by Professor Pamela Shaw.

Newcastle AuthorsTitleYearFull text
Professor Pamela Shaw
Professor Fiona Matthews
Professor Carol Brayne
Type 2 Diabetes Mellitus-Associated Transcriptome Alterations in Cortical Neurones and Associated Neurovascular Unit Cells in the Ageing Brain2021
Dr Connor Richardson
Professor Carol Brayne
Professor Pamela Shaw
Professor Fiona Matthews
Advanced Glycation End Product Formation in Human Cerebral Cortex Increases with Alzheimer-type Neuropathologic Changes but is Not Independently Associated with Dementia in a Population-Derived Aging Brain Cohort2020
Dr Nick Steen
Professor Pamela Shaw
Regionality of disease progression predicts prognosis in amyotrophic lateral sclerosis2015
Professor Stephen Bourke
Professor Pamela Shaw
Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial2015
Professor Pamela Shaw
Dr Nick Steen
Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis2014
Dr Timothy Peel
Professor Pamela Shaw
Emeritus Professor John Gibson
Professor Stephen Bourke
Non-invasive ventilation in motor neuron disease: an update of current UK practice2012
Professor Stephen Bourke
Dr Timothy Peel
Emeritus Professor John Gibson
Professor Pamela Shaw
The changing landscape of non-invasive ventilation in amyotrophic lateral sclerosis2012
Professor Pamela Shaw
Dr Nick Steen
Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic Lateral Sclerosis (LiCALS) [Eudract number: 2008-006891-31]2011
Dr Timothy Peel
Professor Pamela Shaw
Professor Stephen Bourke
Non-invasive ventilation in motor neurone disease: an update of current UK practice [abstract]2010
Professor John O'Brien
Dr Robert Barber
Professor Raj Kalaria
Professor Carol Brayne
Professor Pamela Shaw
et al.
Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways2009
Dr Paula Heath
Professor Carol Brayne
Dr Robert Barber
Professor Raj Kalaria
Professor John O'Brien
et al.
Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways2008
Geoffrey Taylor
Professor Pamela Shaw
Emeritus Professor Doug Turnbull
Professor Robert Taylor
Investigation of the mitochondrial genome in patients with atypical motor neuron disease2007
Dr Phillip Byrne
Professor Patrick Chinnery
Dr Angela Pyle
Professor Pamela Shaw
Linkage to a known gene but no mutation identified: Comprehensive reanalysis of SPG4 HSP pedigrees reveals large deletions as the sole cause2007
Dr Paula Heath
Professor Carol Brayne
Dr Robert Barber
Professor Raj Kalaria
Professor John O'Brien
et al.
Microarray gene expression profiling of deep subcortical lesions in the ageing brain2007
Professor John O'Brien
Dr Robert Barber
Professor Raj Kalaria
Professor Carol Brayne
Professor Pamela Shaw
et al.
Microglial activation in white matter lesions and nonlesional white matter of ageing brains2007
Professor John O'Brien
Dr Robert Barber
Professor Raj Kalaria
Professor Carol Brayne
Professor Pamela Shaw
et al.
Microglial activation in white matter of the ageing brain2007
Professor Patrick Chinnery
Dr Catherine Mowbray
Dr Hannah Elliott
Dr Joanna Elson
Professor Pamela Shaw
et al.
Mitochondrial DNA haplogroups and amyotrophic lateral sclerosis2007
Professor John O'Brien
Dr Robert Barber
Professor Raj Kalaria
Professor Carol Brayne
Professor Pamela Shaw
et al.
White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses2007
Professor Stephen Bourke
Dr Timothy Williams
Dr Robert Bullock
Professor Pamela Shaw
Emeritus Professor John Gibson
et al.
Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: A randomised controlled trial2006
Professor John O'Brien
Dr Robert Barber
Professor Raj Kalaria
Professor Carol Brayne
Professor Pamela Shaw
et al.
Glial cell pathology of periventricular and deep white matter lesions in the ageing brain2006
Professor Carol Brayne
Professor John O'Brien
Professor Raj Kalaria
Professor Pamela Shaw
Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain2006
Professor Carol Brayne
Dr Robert Barber
Professor Raj Kalaria
Professor Pamela Shaw
Professor John O'Brien
et al.
Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain2006
Dr Gillian Borthwick
Professor Robert Taylor
Dr Timothy Walls
Dr Kasia Tonska
Geoffrey Taylor
et al.
Motor neuron disease in a patient with a mitochondrial tRNAlle mutation2006
Professor Stephen Bourke
Dr Robert Bullock
Professor Pamela Shaw
Emeritus Professor John Gibson
Non-invasive ventilation in amyotrophic lateral sclerosis2006
Professor Stephen Bourke
Dr Robert Bullock
Professor Pamela Shaw
A randomised controlled trial of non-invasive ventilation (NIV) in motor neurone disease (MND)2005
Professor John Kirby
Louise Ward
Professor Pamela Shaw
Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosis2005
Professor Stephen Bourke
Professor Pamela Shaw
Dr Robert Bullock
Emeritus Professor John Gibson
Randomised controlled trial of now invasive ventilation in motor neurone disease2004
Professor Stephen Bourke
Professor Elaine McColl
Professor Pamela Shaw
Emeritus Professor John Gibson
Validation of quality of life instruments in ALS2004
Emerita Professor Katherine Bushby
Professor Pamela Shaw
Hereditary Spastic Paraparesis: Disrupted Intracellular Transport Associated with Spastin Mutation2003
Professor Robert Taylor
Christopher Hayes
Emerita Professor Katherine Bushby
Emeritus Professor Doug Turnbull
Professor Pamela Shaw
et al.
Investigation of mitochondrial function in hereditary spastic paraparesis2003
Professor Stephen Bourke
Dr Robert Bullock
Professor Pamela Shaw
Emeritus Professor John Gibson
Noninvasive ventilation in ALS: Indications and effect on quality of life2003
Dr Janine Tomkins
Emerita Professor Katherine Bushby
Professor Pamela Shaw
Spastin and paraplegin gene analysis in selected cases of motor neurone disease (MND)2003
Professor Stephen Bourke
Professor Pamela Shaw
Dr Robert Bullock
Criteria for initiating non-invasive ventilation in motor neuron disease2002
Dr Mark Cookson
Fiona Menzies
Dr Philip Manning
Dr Christopher Eggett
Emeritus Professor Calum McNeil
et al.
Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress2002
Professor John Kirby
Fiona Menzies
Dr Mark Cookson
Emerita Professor Katherine Bushby
Professor Pamela Shaw
et al.
Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease2002
Professor Robert Taylor
Christine Hayes
Emerita Professor Katherine Bushby
Emeritus Professor Doug Turnbull
Professor Pamela Shaw
et al.
Investigation of mitochondrial function in hereditary spastic paraparesis2002
Fiona Menzies
Dr Mark Cookson
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Professor Zofia Chrzanowska-Lightowlers
et al.
Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis2002
Professor Stephen Bourke
Dr Robert Bullock
Emeritus Professor John Gibson
Professor Pamela Shaw
Non-invasive ventilation in motor neuron disease: Current UK practice2002
Professor Stephen Bourke
Professor Pamela Shaw
Dr Timothy Williams
Non-invasive ventilation in motor neuron disease: Current UK practice2002
Professor Stephen Bourke
Professor Pamela Shaw
Dr Robert Bullock
Responsiveness of quality of life instruments and domains to non-invasive ventilation in motor neuron disease2002
Steven Banner
Dr Anne Fray
Dr Mark Cookson
Professor Pamela Shaw
The expression of the glutamate re-uptake transporter excitatory amino acid transporter 1 (EAAT1) in the normal human CNS and in motor neurone disease: An immunohistochemical study2002
Dr Rebecca Williams
Dr Mark Cookson
Dr Anne Fray
Dr Philip Manning
Fiona Menzies
et al.
Cultured glial cells are resistant to the effects of motor neurone disease-associated SOD1 mutations2001
Professor Stephen Bourke
Professor Pamela Shaw
Daytime predictors of nocturnal desaturation in motor neurone disease2001
Dr Janet Lindsey
Dr Meryl Lusher
Emerita Professor Katherine Bushby
Professor Pamela Shaw
Genotype-phenotype correlation in hereditary spastic paraparesis2001
Dr Mark Cookson
Professor Pamela Shaw
Glial cells of the spinal cord and subcortical white matter up-regulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis2001
Dr Anne Fray
Susan Dempster
Dr Rebecca Williams
Dr Mark Cookson
Professor Pamela Shaw
et al.
Glutamine synthetase activity and expression are not affected by the development of motor neuronopathy in the G93A SOD-1/ALS mouse2001
Dr Meryl Lusher
Dr Janet Lindsey
Emeritus Professor Doug Turnbull
Emerita Professor Katherine Bushby
Professor Pamela Shaw
et al.
Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England.2001
Professor Stephen Bourke
Professor Pamela Shaw
Emeritus Professor John Gibson
Respiratory function vs sleep-disordered breathing as predictors of QOL in ALS2001
Dr Philip Manning
Dr Mark Cookson
Emeritus Professor Calum McNeil
Professor Pamela Shaw
Superoxide-induced nitric oxide release from cultured glial cells2001
Dr Peter Tilley
Professor Pamela Shaw
Brown-Vialetto-Van Laere syndrome: Case report and literature review2000
Dr Kathleen White
Dr Meryl Lusher
Dr Janet Lindsey
Professor Pamela Shaw
Emerita Professor Katherine Bushby
et al.
Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation2000
Dr Christopher Eggett
Dr Stephen Crosier
Dr Philip Manning
Fiona Menzies
Emeritus Professor Calum McNeil
et al.
Development and characterisation of a glutamate-sensitive motor neurone cell line2000
Professor Pamela Shaw
Expression of nitric oxide synthase isoforms in spinal cord in amyotrophic lateral sclerosis2000
Dr Kathleen White
Emerita Professor Katherine Bushby
Professor Pamela Shaw
Hereditary spastic paraparesis: a review of new developments2000
Professor Pamela Shaw
Dr Christopher Eggett
Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis2000
Dr Janet Lindsey
Dr Meryl Lusher
Dr Kathleen White
Dr Rumaisa Bashir
Professor Pamela Shaw
et al.
Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis2000
Dr Philip Manning
Dr Mark Cookson
Dr Christopher Eggett
Professor Pamela Shaw
Emeritus Professor Calum McNeil
et al.
Real-time bioelectrochemical investigation of brain injury and neurodegeneration2000
Dr Philip Manning
Dr Mark Cookson
Dr Christopher Eggett
Professor Anthony Thody
Professor Pamela Shaw
et al.
Real-time measurement of free radical production using specific electrochemical sensors: New insight into the consequences of O2/- and NO flux2000
Professor Pamela Shaw
Relapsing ischemic encephaloenteropathy and cryoglobulinemia2000
Dr Janine Tomkins
Susan Dempster
Steven Banner
Dr Mark Cookson
Professor Pamela Shaw
et al.
Screening of AP endonuclease as a candidate gene for amyotrophic lateral sclerosis (ALS)2000
Dr Louise VB Anderson
Ruth Harrison
Dr Robert Pogue
Dr Elizabeth Vafiadaki
Jennifer Moss
et al.
Secondary reduction in calpain 3 expression in patients with limb girdle muscular dystrophy type 2B and Miyoshi myopathy (primary dysferlinopathies)2000
Professor Pamela Shaw
Dr Rebecca Williams
Serum and cerebrospinal fluid biochemical markers of ALS2000
Professor Pamela Shaw
A career in academic medicine: personal experiences1999
Professor Pamela Shaw
Calcium, glutamate, and amyotrophic lateral sclerosis: More evidence but no certainties1999
Professor Pamela Shaw
Janet Slade
Dr Christopher Eggett
Low expression of GluR2 AMPA receptor subunit protein by human motor neurons1999
Dr Gillian Borthwick
Dr Margaret Johnson
Professor Pamela Shaw
Emeritus Professor Doug Turnbull
Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death1999
Dr Mark Cookson
Professor Pamela Shaw
Oxidative stress and motor neurone disease1999
Dr Mark Cookson
Professor Pamela Shaw
Poly(ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons1999
Professor Pamela Shaw
Relapsing ischaemic encephalo-enteropathy in cryoglobulinaemia1999
Professor Pamela Shaw
Science, medicine, and the future - Motor neurone disease1999
Professor Pamela Shaw
Stiff-man syndrome and its variants1999
Dr Thomas Meyer
Dr Anne Fray
Professor Pamela Shaw
The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals1999
Mary Johnson
Emeritus Professor Elaine Perry
Professor Pamela Shaw
Emeritus Professor Robert Perry
Autoradiographic comparison of the distribution of [3H]MK801 and [3H]CNQX in the human cerebellum during development and aging1993
Emeritus Professor Elaine Perry
Dr Janet Kerwin
Dr Margaret Piggott
Dr Jennifer Court
Professor Pamela Shaw
et al.
Convergent cholinergic activities in aging and Alzheimer's disease1992