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Browsing publications by Dr Rachel Lakey.

Newcastle AuthorsTitleYearFull text
Professor Christopher Price
Dr Lisa Shaw
Dr Mehdi Javanbakht
Dr Peter McMeekin
Dr Darren Flynn
et al.
Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment (PASTA) on Thrombolysis Delivery During Emergency Stroke Care: A Cluster Randomised Clinical Trial2020
Professor Phil White
Dr Barbara Gregson
Dr Adela Cora
Dr Anand Dixit
Dr Rachel Lakey
et al.
Evaluation of stroke thrombectomy including patients where IV thrombolysis is contraindicated or has failed: A randomized trial of two novel thrombectomy devices2020
Professor Christopher Price
Dr Lisa Shaw
Professor Catherine Exley
Dr Darren Flynn
Emeritus Professor Roger Francis
et al.
Paramedic Acute Stroke Treatment Assessment (PASTA): study protocol for a randomised controlled trial2019
Professor Christopher Price
Dr Stuart Huntley
Dr Rachel Lakey
Estimated GFR and the Effect of Intensive Blood Pressure Lowering after Acute Intracerebral Hemorrhage2016
Professor Phil White
Dr Rachel Lakey
Observer Reliability of CT Angiography in the assessment of acute ischaemic stroke: Data from the Third International Stroke Trial2015
Mark Houseman
Dr Kate Potter
Nicola Marshall
Dr Rachel Lakey
Emeritus Professor Tim Cawston
et al.
Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up2012
Professor Phil White
Dr Rachel Lakey
The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): A randomised controlled trial2012
Dr Kenneth Rankin
Dr Rachel Lakey
Craig Gerrand
Andrew Sprowson
Professor Andrew McCaskie
et al.
A Novel in Vitro Model to Investigate Behavior of Articular Chondrocytes in Osteoarthritis2010
Emeritus Professor Tim Cawston
Dr Rachel Lakey
Emeritus Professor Drew Rowan
Assay of matrix metalloproteinases against matrix substrates2010
Dr Matthew Barter
Dr Rachel Lakey
Dr Jonathan Catterall
Emeritus Professor Tim Cawston
Professor David Young
et al.
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation2010
Dr Rachel Lakey
Emeritus Professor Drew Rowan
Professor John Isaacs
Emeritus Professor Tim Cawston
Dr Catharien Hilkens
et al.
A novel paradigm for dendritic cells as effectors of cartilage destruction2009
Dr Rachel Lakey
Emeritus Professor Tim Cawston
Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases2009
Dr Kenneth Rankin
Dr Rachel Lakey
Craig Gerrand
Andrew Sprowson
Professor Andrew McCaskie
et al.
A novel in vitro model of osteoarthritis facilitates improved understanding of human articular chondrocyte behaviour2008
Dr Kenneth Rankin
Craig Gerrand
Dr Rachel Lakey
Andrew Sprowson
Professor Andrew McCaskie
et al.
Hypoxia facilitates bone invasion by increasing breast cancer cell expression of matrix metalloproteinase-12008
Dr Gary Litherland
Dr Craig Dixon
Dr Rachel Lakey
Tim Robson
David Jones
et al.
Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent2008
Emeritus Professor Tim Cawston
Dr Rachel Lakey
Debra Jones
Dr Jonathan Catterall
Emeritus Professor Robin Seymour
et al.
Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines2007
Dr Jonathan Catterall
Dr Rachel Lakey
Emeritus Professor Tim Cawston
Investigation into the potential chondroprotective effects of ciclosporin in arthritis2006
Dr Emma Barksby
Dr Jenny Milner
Dr Angela Patterson
Dr Nicholas Peake
Tim Robson
et al.
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis2006
Dr Rachel Lakey
Dr Jonathan Catterall
Emeritus Professor Tim Cawston
Mevastatin and simvastatin block collagen release from bovine cartilage and downregulate MMP-13 from human articular chondrocytes2006
Professor David Young
Dr Rachel Lakey
Professor David Jones
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption2005
Professor David Young
Dr Rachel Lakey
David Jones
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption2005
Professor David Young
Dr Rachel Lakey
David Jones
Emeritus Professor Tim Cawston
Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane-associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -22005
Professor David Young
Dr Rachel Lakey
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors are chondroprotective2004
Dr Andrea Myers
Dr Rachel Lakey
Emeritus Professor Tim Cawston
Dr Lesley Kay
Serum MMP-1 and TIMP-1 levels are increased in patients with psoriatic arthritis and their siblings2004