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Browsing publications by Dr John Mansfield.

Newcastle AuthorsTitleYearFull text
Dr Chris Lamb
Dr John Mansfield
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility2022
Dr Chris Lamb
Dr John Mansfield
Oral ferric maltol does not adversely affect the intestinal microbiome of patients or mice, but ferrous sulphate does2021
Dr Meghan Acres
Dr Gill Hulme
Dr Christopher Carey
Dr John Mansfield
Professor John Kirby
et al.
Regulation and role of αE integrin and gut homing integrins in migration and retention of intestinal lymphocytes during inflammatory bowel disease2021
Dr John Mansfield
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease2020
Dr John Mansfield
Association of Genetic Variants in NUDT15 with Thiopurine-Induced Myelosuppression in Patients with Inflammatory Bowel Disease2019
Emeritus Professor Nicol Ferrier
Professor John Isaacs
Dr John Mansfield
Professor Allan Young
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data2019
Dr Chris Lamb
Dr John Mansfield
Professor John Kirby
The Importance of Molecular Immune Investigation in Therapeutic Clinical Development for Biomarker Assessment2019
Dr Chris Lamb
Dr John Mansfield
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease2018
Dr Chris Lamb
Anna Long
Dr John Mansfield
Professor John Kirby
AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation2018
Dr John Mansfield
Can faecal calprotectin predict relapse in inflammatory bowel disease: A mini review2018
Dr John Mansfield
Exome sequencing and genotyping identify a rare variant in NLRP7 gene associated with ulcerative colitis2018
Dr John Mansfield
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes2018
Dr Chris Lamb
Dr John Mansfield
The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease2018
Dr Chris Lamb
Dr John Mansfield
Anna Long
Maria Price
Dr Graeme O'Boyle
et al.
aEß7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis2017
Dr Ally Speight
Dr John Mansfield
Editorial: how effective is vedolizumab in the 'real world'?2017
Dr Chris Lamb
Dr John Mansfield
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY72017
Dr John Mansfield
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease2017
Dr Chris Lamb
Dr John Mansfield
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease2017
Dr John Mansfield
A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies2016
Dr Chris Lamb
Dr John Mansfield
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis2016
Dr Chris Lamb
Dr John Mansfield
Professor John Kirby
Association Between Response to Etrolizumab and Expression of Integrin alpha E and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis2016
Dr John Mansfield
Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease2016
Dr John Mansfield
Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis2016
Dr John Mansfield
Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial2016
Dr John Mansfield
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: A genetic association study2016
Dr Richard Speight
Tracey Davey
Dr Kathryn White
Professor John Kirby
Dr John Mansfield
et al.
Activation of the bile acid receptor, farnesoid-x receptor, maintains gut epithelial cell morphology, possibly via inhibition of myosin light chain kinase expression2015
Dr Richard Speight
Anna Whitehead
Dr Gillian Patman
Dr John Mansfield
Professor Helen Reeves
et al.
Activation of the bile acid receptor, Farnesoid-X Receptor, may reduce Ileal Inflammatory Cytokine expression in an animal model of diet-induced obesity2015
Dr Chris Lamb
Dr John Mansfield
Jennifer Kirby
AlphaE (alpha E) integrin protein and gene expression are augmented in the ileum relative to the colon in Crohn's disease2015
Dr John Mansfield
High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis2015
Dr John Mansfield
Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes2015
Dr Chris Lamb
Dr John Mansfield
Predicting inflammatory pathology at capsule enteroscopy: what is the utility of a raised faecal calprotectin?2015
Dr John Mansfield
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants2014
Dr Michael Keir
Dr John Mansfield
Dr Chris Lamb
Professor John Kirby
AlphaE integrin expression as a predictive biomarker for induction of clinical remission by etrolizumab: Analysis of a phase II trial in moderate-to-severely active ulcerative colitis2014
Dr John Mansfield
Dr Chris Lamb
Professor John Kirby
Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial2014
Dr Chris Lamb
Maria Price
Dr John Mansfield
Faecal Calprotectin Is Useful In Predicting Long Term Disease Recurrence In Post-operative Crohn’s2014
Dr Chris Lamb
Dr John Mansfield
The Impact Of NOD2 Variants on Gut Microbiota in Crohn’s Disease and Healthy Controls2014
Dr Carl Gamble
Dr Chris Lamb
Dr John Mansfield
Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients2014
Dr Chris Lamb
Dr John Mansfield
Dr Graeme O'Boyle
Professor David Jones
Jennifer Kirby
et al.
Ulcerative colitis: The alpha E beta 7 integrin is associated with a high frequency of Th17, Th1 and Th17/Th1 CD4 lymphocytes2014
Dr Chris Lamb
Dr John Mansfield
Dr Graeme O'Boyle
Professor David Jones
Dr Michael Keir
et al.
Ulcerative Colitis: The Alpha-e-beta-7 Integrin Is Associated With A High Frequency Of Th17, Th1 And Th17/th1 Cd4 Lymphocytes2014
Dr Leslie Mitchell
Dr John Mansfield
Dr Janet McLelland
Dr Stephanie Needham
Vulval oedema: how many doctors does it take to make a diagnosis?2014
Dr John Mansfield
A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis2013
Dr Chris Lamb
Dr Lily Lamb
Dr John Mansfield
Sexually transmitted infections manifesting as proctitis2013
Dr Chris Lamb
Dr Graeme O'Boyle
Professor David Jones
Dr John Mansfield
Professor John Kirby
et al.
Blockade of the B7 integrin prevents adherence of t lymphocytes to MAdCAM-1 in an in vitro model of vascular microcirculation post-capillary shear flow2012
Dr John Mansfield
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease2012
Dr Catherine Stroud
Professor Matthew Collin
Professor Graham Jackson
Dr Terence Flood
Dr John Mansfield
et al.
Idiopathic colitis following haematopoietic stem cell transplantation for chronic granulomatous disease: Three cases at a national centre2012
Dr Chris Lamb
Maria Price
Dr John Mansfield
A real life retrospective analysis of drug expenditure reveals no significant cost difference between infliximab and adalimumab in the treatment of Adult Crohn's Disease2011
Dr Chris Lamb
Dr John Mansfield
Measurement of faecal calprotectin and lactoferrin in inflammatory bowel disease2011
Dr John Mansfield
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 472011
Dr Chris Lamb
Maria Price
Professor David Jones
Dr John Mansfield
Patients with Crohn's Disease report high levels of fatigue during a symptomatic disease flare2011
Dr John Mansfield
Screening for rare pathogenic sequence variants in inflammatory bowel disease2011
Dr Catherine Stroud
Dr John Mansfield
Dr Terence Flood
Dr Gavin Spickett
Diagnostic dilemma2010
Emeritus Professor Nicol Ferrier
Professor John Isaacs
Dr John Mansfield
Professor Mark Walker
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls2010
Dr John Mansfield
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci2010
Dr John Mansfield
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease2010
Dr John Mansfield
Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease2010
Dr Sohom Maitra
Dr Chris Lamb
Dr Andrew McLean-Tooke
Dr Gavin Spickett
Dr John Mansfield
et al.
Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease2009
Dr Chris Lamb
Mohamed Mohiuddin
Fintan Bergin
Dr Jonathan Hanson
Dr John Mansfield
et al.
Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn's disease2009
Lynsey Cotterill
Dr John Mansfield
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region2009
Dr John Mansfield
Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship2009
Dr Chris Lamb
Mohamed Mohiuddin
Fintan Bergin
Dr Jonathan Hanson
Dr John Mansfield
et al.
Longitudinal Study of Faecal Markers Following Ileal Resection in Crohn's Disease: Do Calprotectin and Lactoferrin Normalise Post Operatively?2009
Mohamed Mohiuddin
Dr Chris Lamb
Fintan Bergin
Dr Jonathan Hanson
Dr John Mansfield
et al.
Post Operative Crohn's Disease: The Role of Faecal Calprotectin and Lactoferrin in Assessing Disease Recurrence Following Ileal Resection2009
Dr John Mansfield
Safety of bisphosphonates in women of child bearing age2009
Dr John Mansfield
Searching for Genotype-Phenotype Structure: Using Hierarchical Log-Linear Models in Crohn Disease2009
Dr John Mansfield
Association of a promoter variant and copy number polymorphisms at the IRGM locus with Crohn's disease2008
Dr John Mansfield
Copy Number Variation at the Crohn's disease susceptibility locus, IRGM2008
Dr John Mansfield
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease2008
Dr John Mansfield
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease2008
Dr Catherine Todhunter
Dr John Mansfield
A non-synonymous SNP in an autophagy-related gene is associated with Crohn's disease2007
Dr John Mansfield
A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn's Disease and Is Independent of CARD15 and IBD52007
Dr John Mansfield
A randomized, double-blind, placebo-controlled trial of lenalidomide in the treatment of moderately severe active Crohn's disease2007
Dr Sohom Maitra
Dr Gavin Spickett
Dr John Mansfield
Anti-tissue transglutaminase antibody quantification is useful in the follow-up of coeliac disease patients2007
Dr Catherine Todhunter
Dr Peter Donaldson
Dr John Mansfield
Combined Evidence From Three Large British Association Studies Rejects TUCAN/CARD8 as an IBD Susceptibility Gene2007
Professor Allan Young
Emeritus Professor Nicol Ferrier
Mohamed Mohiuddin
Dr Catherine Todhunter
Dr John Mansfield
et al.
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls2007
Dr John Mansfield
IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease2007
Dr Catherine Todhunter
Dr John Mansfield
In situ hybridisation for human defensins, lysozyme, spla2 and TNF alpha in Crohn's disease and controls2007
Dr John Mansfield
Investigation of assocaiation of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population2007
Dr John Mansfield
Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population2007
Dr John Mansfield
Reply2007
Dr Catherine Todhunter
Dr John Mansfield
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility2007
Dr Catherine Todhunter
Dr John Mansfield
5Q31 haplotype and relapse after small bowel resection2006
Dr Katrina Robinson
Dr John Mansfield
Audit of inflammatory bowel disease clinics: Results from two patient satisfaction surveys2006
Dr John Mansfield
Direct or indirect association in a complex disease: The role of SLC22A4 and SLC22A5 functional variants in Crohn disease2006
Dr Catherine Todhunter
Lyn Wilkinson
Alison Burt
Dr John Mansfield
Histological phenotype of CARD15 genotype2006
Dr John Mansfield
Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD152006
Dr Nicholas Thompson
Dr John Mansfield
Adenocarcinoma as a complication of small bowel Crohn's disease2005
Dr John Mansfield
Association of DLG5 R30Q variant with inflammatory bowel disease2005
Dr Catherine Todhunter
Maria Price
Alison Sutherland-Craggs
Dr Peter Donaldson
William Cunliffe
et al.
CARD 15, smoking, and time to second operation in ileal Crohn's disease2005
Dr John Mansfield
How Good is Zoom Endoscopy in Assessing Villous Atrophy in Coeliac Disease?2005
Dr Steven Masson
Dr John Mansfield
How important is onset of action in ulcerative colitis therapy?2005
Dr Catherine Todhunter
Dr Alison Sutherland
Dr Peter Donaldson
Professor Ann Daly
Emeritus Professor Roger Francis
et al.
Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease2005
Dr John Mansfield
Multiple SNPs at the IBD5 locus contribute to the risk of Crohn's disease2005
Dr John Mansfield
Review article: smoking cessation as primary therapy to modify the course of Crohn's disease2005
Dr John Mansfield
Yersinia enterocolitica infection in a patient with hemachromatosis masquerading as proximal colon cancer with liver metastases: Report of a case2005
Dr John Mansfield
Fine mapping of the 5q31 risk haplotype in Crohn's disease2004
John Wayman
Dr John Mansfield
Dr Kenneth Matthewson
Dr David Richardson
Professor Michael Griffin
et al.
Combined percutaneous and endoscopic procedures for bile duct obstruction: Simultaneous and delayed techniques compared2003
Dr John Mansfield
Dr Peter Donaldson
Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease2003
Dr John Mansfield
Dr Peter Donaldson
Genetic evidence for interaction of the 5Q31 cytokine locus and the CARD15 gene in Crohn's disease2003
Dr John Mansfield
Genetic variation at the chromosome 16 chemokine gene cluster: Development of a strategy for association studies in complex disease2003
Dr Alison Sutherland
Dr John Mansfield
Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease2003
Dr John Mansfield
Management of irritable bowel syndrome2003
Alison Sutherland-Craggs
Dr John Mansfield
Dr Peter Donaldson
Professor Ann Daly
Dr Nicholas Thompson
et al.
Osteoporosis in Crohn's disease is not determined by vitamin D receptor and interleukin-6 genotype2003
Dr John Mansfield
Pentasa may not be the optimal 5ASA2003
Dr Ahmed Jaafar
Dr John Mansfield
Dr Nicholas Thompson
Screening for malnutrition: Impact of the malnutrition universal screening tool (MUST)2003
Dr John Mansfield
Sequence variation in the CARD15 (nod2) gene and susceptibility to Crohn's disease2003
Dr John Mansfield
Which 5-ASA?2003
Dr John Mansfield
A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis2002
Dr John Mansfield
A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis2002
Dr John Mansfield
Contribution of genetic variants at CARD15 and the chromosome 5q31 locus to Crohn's disease2002
Alison Sutherland-Craggs
Dr John Mansfield
Dr Mark Hudson
Professor Ann Daly
Emeritus Professor Roger Francis
et al.
Osteoporosis in Crohn's disease is not determined by NOD2 genotype [abstract]2002
Dr John Mansfield
Smoking cessation in Crohn's disease: Worthwhile results are possible [abstract]2002
Dr John Mansfield
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease2002
Dr Ann Curtis
Dr Mark Welfare
Dr Mark Hudson
Dr Peter Donaldson
Dr John Mansfield
et al.
Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and crohn disease in multiple populations from northeast England2001
Dr Peter Donaldson
Dr Mark Welfare
Dr Nicholas Thompson
Dr John Mansfield
Genetic association studies in IBD; Negative results from three candidate genes2001
Dr John Mansfield
Review article: The risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment2001
Dr Alison Sutherland
Professor Chris Day
Dr Mark Welfare
Professor Ann Daly
Dr John Mansfield
et al.
Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease2001
Dr Alison Sutherland
Dr Mark Welfare
Dr Peter Donaldson
Dr John Mansfield
The CC chemokine receptor 5 Delta 32 mutation is not associated with inflammatory bowel disease (IBD) in NE England2001
Dr Dale Huey
Dr John Mansfield
Dr Stefan Plusa
Psychological factors which influence adjustment to inflammatory bowel disease2000
Dr David Nylander
Dr Michael Bramble
Dr John Mansfield
Recurrent Crohn's disease after surgery is dependent on timing of surgery and smoking, but not on use of 5ASA drugs1999
Dr John Mansfield
Richard Charnley
Practice in endoscopic cholangiopancreatography in Denmark differs from that in Britain1996