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Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Lookup NU author(s): Professor Julie Irving, Professor James Allan, Professor Anthony MoormanORCiD, Professor Christine Harrison FRCPath FMedSci


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Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

Publication metadata

Author(s): Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2010

Volume: 42

Issue: 6

Pages: 492-494

Print publication date: 01/06/2010

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group


DOI: 10.1038/ng.585


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Funder referenceFunder name
Children with Leukemia
Deutsche Krebshilfe
Leukemia Research (UK)
National Sciences and Engineering Research Council Canada
Kay Kendall Leukemia Fund
C1298/A8362Cancer Research UK
Food-CT-2005-016320Tumorzentrum Heidelberg-Mannheim, EU
GVOP 3.1.1-2004-05-0022/3.0Economic Competitiveness Operational Programme, Hungary
Health-F3-2007-2007-200767Tumorzentrum Heidelberg-Mannheim, EU
TECH_ 08-A1/2-2008-0120NKTH (National Research and Technology)
T042500Hungarian Scientific Research Fund