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Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

Lookup NU author(s): Hannah Ensor, Claire Schwab, Dr Lisa Russell, Professor Christine Harrison FRCPath FMedSci, Professor Anthony MoormanORCiD


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The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+ , 15 IGH@-CRLF2+ ), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0.37 +/- 0.06 vs. 0.25 +/- 0.08 (P = 0.194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.

Publication metadata

Author(s): Attarbaschi A, Morak M, Cario G, Cazzaniga G, Ensor HM, te Kronnie T, Bradtke J, Mann G, Vendramini E, Palmi C, Schwab C, Russell LJ, Schrappe M, Conter V, Mitchell CD, Strehl S, Zimmermann M, Potschger U, Harrison CJ, Stanulla M, Panzer-Grumayer R, Haas OA, Moorman AV, Assoc Italiana Ematologia Oncologi, Natl Canc Res Inst NCRI-Childrens

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2012

Volume: 158

Issue: 6

Pages: 772-777

Print publication date: 23/07/2012

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1365-2141.2012.09221.x


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Funder referenceFunder name
Associazione Italiana Contro le Leucemie
Associazione Italiana per la Ricerca sul Cancro
Fondazione Cariplo
Kinderkrebsinitiative Buchholz/Holm-Seppensen
St. Anna Kinderkrebsforschung
Deutsche Krebshilfe
Fondazione Citta della Speranza
Leukaemia and Lymphoma Research of the UK
ONB 14129Austrian National Bank