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Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism

Lookup NU author(s): Dr Karim Bennaceur, Mark Atwill, Nayef Al Zhrany, Jedrzej Hoffmann, Professor Bernard Keavney, Dr Gavin Richardson, Professor Thomas von Zglinicki, Dr Gabriele Saretzki, Professor Ioakim Spyridopoulos

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Abstract

Statins are one of the most potent drugs in delaying age-related inflammatory changes in the arterial vessel wall, slowing down the progression of atherosclerosis. Statins have also been shown to abrogate telomere-attributed cardiovascular risk. The goal of our study was to explore a potential effect of atorvastatin on telomerase activity in peripheral blood mononuclear cells (PBMCs) and T-lymphocytes (T cells).


Publication metadata

Author(s): Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I

Publication type: Article

Publication status: Published

Journal: Atherosclerosis

Year: 2014

Volume: 236

Issue: 2

Pages: 312-320

Print publication date: 01/10/2014

Online publication date: 04/08/2014

Acceptance date: 21/07/2014

Date deposited: 04/08/2015

ISSN (print): 0021-9150

ISSN (electronic): 1879-1484

Publisher: Elsevier Ireland Ltd.

URL: http://dx.doi.org/10.1016/j.atherosclerosis.2014.07.020

DOI: 10.1016/j.atherosclerosis.2014.07.020

PubMed id: 25127175


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