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Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Lookup NU author(s): Dr Laura Greaves, Marco Nooteboom, Dr Joanna Elson, Dr Helen Tuppen, Geoffrey Taylor, Dr Daniel Commane, Dr Ramesh Arasaradnam, Professor Robert Taylor, Emeritus Professor Thomas Kirkwood, Professor John Mathers, Emeritus Professor Doug Turnbull



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Publication metadata

Author(s): Greaves LC, Nooteboom M, Elson JL, Tuppen HAL, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TBL, Mathers JC, Turnbull DM

Publication type: Article

Publication status: Published

Journal: PLoS Genetics

Year: 2014

Volume: 10

Issue: 9

Online publication date: 18/09/2014

Acceptance date: 21/07/2014

Date deposited: 08/10/2014

ISSN (print): 1553-7390

ISSN (electronic): 1553-7404

Publisher: Public Library of Science


DOI: 10.1371/journal.pgen.1004620


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Funder referenceFunder name
Ellison Medical Foundation
NIHR Newcastle Biomedical Research Centre based at Newcastle upon Newcastle University
NIHR Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals National Health Service Foundation Trust
Newcastle University Centre for Brain Ageing and Vitality
UK NHS Highly Specialised "Rare Mitochondrial Disorders of Adults and Children" Service
096919Z/11/ZWellcome Trust Centre for Mitochondrial Research
G0700718MRC as part of the cross-council Lifelong Health and Wellbeing Initiative
G0601943Medical Research Council (UK) Centre for Translational Muscle Disease research
N12015Food Standards Agency