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Lookup NU author(s): Professor Caroline AustinORCiD,
Dr Andrew Porter,
Dr Nick Morris,
Dr Ian Cowell
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Type II DNA topoisomerases (EC 220.127.116.11) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery.
Author(s): Austin CA, Lee KC, Swan RL, Khazeem MM, Manville CM, Cridland P, Treumann A, Porter A, Morris NJ, Cowell IG
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Online publication date: 14/09/2018
Acceptance date: 11/09/2018
ISSN (print): 1661-6596
ISSN (electronic): 1422-0067
Publisher: MDPI AG