Publications by Professor Caroline Austin - ePrints

Browsing publications by Professor Caroline Austin.

Newcastle Authors	Title	Year
Mushtaq Khazeem Professor Caroline Austin	Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage	2024
Dr Ian Cowell Professor Caroline Austin	Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti-cancer drug etoposide	2024
Dr Ian Cowell Professor Caroline Austin	DNA fragility at the KMT2A/MLL locus: insights from old and new technologies	2023
Dr Ian Cowell John Casement Professor Caroline Austin	To Break or Not to Break: The Role of TOP2B in Transcription	2023
Elise Ling Dr Arnaud Basle Dr Ian Cowell Professor Bert van den Berg Professor Caroline Austin et al.	A comprehensive structural analysis of the ATPase domain of Human DNA topoisomerase II Beta bound to AMPPNP, ADP and the bisdioxopiperazine, ICRF193	2022
Dr Ian Cowell Professor Caroline Austin	Disease-associated Mutations in Topoisomerase IIβ Result in Defective NK cells	2022
Professor Caroline Austin	Human topoisomerases and their roles in genome stability and organization	2022
Rebecca Swan Dr Ian Cowell Professor Caroline Austin	Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes	2022
Mushtaq Khazeem John Casement Dr Niall Kenneth Jade McGow Dr Ian Cowell et al.	TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA‑Induced Differentiation of SH‑SY5Y Neuroblastoma Cells	2022
Dr Katja Menger Dr James Chapman Mushtaq Khazeem Dr Dasha Deen John Casement et al.	Two type I topoisomerases maintain DNA topology in human mitochondria	2022
Rebecca Swan Dr Ian Cowell Professor Caroline Austin	A role for VCP/p97 in the processing of drug-stabilized TOP2-DNA covalent complexes	2021
Professor Caroline Austin	Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions	2021
Professor Caroline Austin Dr Ian Cowell Mushtaq Khazeem Dawn Lok Huei Teng Ng et al.	TOP2B’s contributions to transcription	2021
Rebecca Swan Luke Poh Dr Ian Cowell Professor Caroline Austin	Small molecule inhibitors confirm ubiquitin-dependent removal of TOP2-DNA covalent complexes	2020
Mushtaq Khazeem Dr Ian Cowell Lauren Harkin John Casement Professor Caroline Austin et al.	Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta	2020
Professor Caroline Austin	A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents.	2019
Dr Mandeep Atwal Rebecca Swan Ka Lee Dr David Lee Professor Lyle Armstrong et al.	Intercalating TOP2 poisons attenuate topoisomerase action at higher concentrations	2019
Dr Ian Cowell Professor Caroline Austin	Mutations in topoisomerase IIβ result in a B cell immunodeficiency	2019
Dr Ian Cowell Elise Ling Becky Swan Professor Caroline Austin	The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison s	2019
Becky Swan Dr Zbyslaw Sondka Dr Ian Cowell Professor Caroline Austin	Effect of TDP2 on the level of TOP2-DNA complexes and SUMOylated TOP2-DNA complexes	2018
Professor Caroline Austin Ka Lee Becky Swan Mushtaq Khazeem Catriona Manville et al.	TOP2B: The first thirty years	2018
Dr Ian Cowell Professor Caroline Austin	Topoisomerase II chromatin immunoprecipitation	2018
Dr Ian Cowell Professor Caroline Austin	Visualization and quantification of topoisomerase–DNA covalent complexes using the trapped in agarose immunostaining (TARDIS) assay	2018
Dr Mandeep Atwal Emma Lishman-Walker Professor Caroline Austin Dr Ian Cowell	Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy	2017
Professor Caroline Austin	Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity	2017
Lauren Harkin Ayman Alzu'bi Professor Caroline Austin Dr Gavin Clowry	Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon	2016
Ka Lee Becky Swan Dr Ian Cowell Professor Graham Jackson Professor Caroline Austin et al.	Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II	2016
Dr Ian Cowell Professor Caroline Austin	Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule-Based Targeting of Topoisomerase II Alpha	2015
Angelica Mariani Dr Mandeep Atwal Ka Lee Professor Caroline Austin	Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules	2015
Catriona Manville Kayleigh Smith Dr Zbyslaw Sondka Holly Rance Dr Ian Cowell et al.	Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells	2015
Professor Caroline Austin	A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation	2014
Andy Best Caroline Dalgliesh Elaine Hong Mahsa Kheirollahi Kouhestani Dr Yaobo Xu et al.	Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons	2014
Professor Caroline Austin	Salicylate, a Catalytic Inhibitor of Topoisomerase II, Inhibits DNA Cleavage and Is Selective for the alpha Isoform	2014
Kayleigh Smith Dr Ian Cowell Dr Zbyslaw Sondka Professor Caroline Austin	The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1	2014
Professor Caroline Austin	TopoisomeraseII beta Is Involved in Initiation of Interstrand Cross-Link Repair in Mammals	2014
Professor Caroline Austin Dr Miguel Lopez-Lazaro	Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death	2013
Dr Ian Cowell Professor Caroline Austin	Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?	2012
Professor Caroline Austin Dr Miguel Lopez-Lazaro	Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death	2012
Dr Ian Cowell Professor Caroline Austin	Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents	2012
Dr Ian Cowell Dr Zbyslaw Sondka Kayleigh Smith Ka Lee Catriona Manville et al.	Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity	2012
Dr Kay Padget Hannah Curtis Dr Ian Cowell Dr Zbyslaw Sondka Dr Nick Morris et al.	MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA	2012
Professor Caroline Austin Dr Miguel Lopez-Lazaro	The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I- and II-DNA Complexes in Cells	2012
Pauline Heslop Professor Caroline Austin	The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage	2012
Catriona Manville Professor Caroline Austin	Topoisomerase II alpha sites of occupancy on human chromosome 22	2012
Dr Ian Cowell Dr Michael Tilby Professor Caroline Austin	An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay	2011
Dr Miguel Lopez-Lazaro Professor Caroline Austin	Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide	2011
Dr Ian Cowell Dr Nikolaos Papageorgiou Dr Kay Padget Professor Caroline Austin	Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin	2011
Dr Masafumi Ihara Professor Caroline Austin	Poly(ADP-ribose) Metabolism Is Essential for Proper Nucleoprotein Exchange During Mouse Spermiogenesis	2011
Professor Caroline Austin	Poly(ADP-Ribose) Polymerases PARP1 and PARP2 Modulate Topoisomerase II Beta (TOP2B) Function During Chromatin Condensation in Mouse Spermiogenesis	2011
Kathryn Gilroy Professor Caroline Austin	The Impact of the C-Terminal Domain on the Interaction of Human DNA Topoisomerase II alpha and beta with DNA	2011
Dr Nicola Sunter Dr Ian Cowell Dr Elaine Willmore Gary Watters Professor Caroline Austin et al.	Role of Topoisomerase IIbeta in DNA Damage Response following IR and Etoposide	2010
Dr Miguel Lopez-Lazaro Dr Elaine Willmore Professor Caroline Austin	The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells	2010
Holly Rance Professor Caroline Austin	The effect of quinolones on human type II topoisomerases using the Trapped in AgaRose DNA ImmunoStaining (TARDIS) assay	2010
Catriona McComb Professor Caroline Austin	Use of genotoxicity endpoints to determine the genotoxic potential of PI3-kinase inhibitors	2010
Professor Caroline Austin Dr Ian Cowell Dr Michael Tilby	Visualisation and quantitation of DNA adducts using the Trapped in Agarose DNA immunostaining (TARDIS) assay	2010
Professor Caroline Austin	Does oxidative damage contribute to the generation of leukemia?	2009
Gary Watters Professor Caroline Austin	Evaluating the gamma H2AX focus assay to assess genotoxicity	2009
Gary Watters Professor Caroline Austin	H2AX phosphorylation as a genotoxicity endpoint	2009
Catriona McComb Professor Caroline Austin	Investigations into kinase associated genotoxicity	2009
Catriona McComb Professor Caroline Austin	Kinases as therapeutic agents: a new potential genetic toxicology liability	2009
Professor Caroline Austin	Model for generation of chromosomal translocations in leukaemia	2009
Dr Elaine Willmore Dr sarah Johnson Dr Tryfonia Mainou-Fowler Professor Graham Jackson Dr Celine Cano et al.	DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia	2008
Andrew Jobson Dr Elaine Willmore Dr Michael Tilby Professor Caroline Austin	Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases	2008
Dr Ian Cowell Professor Caroline Austin	NK314, a Topoisomerase II inhibitor that specifically targets the α isoform	2008
Dr Miguel Lopez-Lazaro Dr Elaine Willmore Dr sarah Johnson Professor Caroline Austin	Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells	2008
Dr Emma Meczes Kathryn Gilroy Professor Caroline Austin	The impact of the human DNA topoisomerse II C-terminal domain on activity	2008
Catriona Manville Dr Emma Clark Dr Kay Padget james Harvey Dr Nick Morris et al.	Bioinformatic analysis of topoisomerase II binding sites	2007
Dr Miguel Lopez-Lazaro Dr Elaine Willmore Professor Caroline Austin	Cells lacking DNA topoisomerase IIβ are resistant to genistein	2007
Dr Miguel Lopez-Lazaro Dr Elaine Willmore Andrew Jobson Kathryn Gilroy Hannah Curtis et al.	Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells	2007
Gary Watters Professor Caroline Austin	Is H2AX phosphorylation a biomarker for genotoxicity?	2007
Dr Ian Cowell Dr Nicola Sunter Professor Caroline Austin Professor barbara Durkacz Dr Michael Tilby et al.	γH2AX foci form preferentially in euchromatin after ionising-radiation	2007
Dr Miguel Lopez-Lazaro Sami Azrak Professor Caroline Austin	Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells	2006
Kathryn Gilroy Chrysoula Leontiou Dr Kay Padget Professor Jeremy Lakey Professor Caroline Austin et al.	mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity	2006
Chrysoula Leontiou Professor Jeremy Lakey Professor Robert Lightowlers Professor Caroline Austin	Mutation P732L in human DNA topoisomerase II abolishes DNA cleavage in the presence of calcium and confers drug resistance	2006
Professor Caroline Austin	Nick-forming sequences may be involved in the organization of eukaryotic chromatin into ∼50 kbp loops	2006
Dr Elaine Willmore Professor Graham Jackson Dr Tryfonia Mainou-Fowler Professor Caroline Austin Professor barbara Durkacz et al.	Sensitisation of B-CLL cells to chlorambucil and fludarabine via inhibition of the DNA damage sensor proteins, DNA-PK and ATM	2006
Dr Miguel Lopez-Lazaro Sami Azrak Dr Muhammad Ayub Professor Caroline Austin	Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients	2005
Lisa Smith Dr Elaine Willmore Professor Caroline Austin Professor Nicola Curtin	The novel poly(ADP-ribose) polymerase inhibitor, AG14361 sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks	2005
Dr Elaine Willmore Dr Nicola Sunter Dr Michael Tilby Professor Graham Jackson Professor Caroline Austin et al.	A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia	2004
Fiona Errington Dr Elaine Willmore Chrysoula Leontiou Dr Michael Tilby Professor Caroline Austin et al.	Differences in the longevity of topo IIα and topo IIβ drug-stabilized cleavable complexes and the relationship to drug sensitivity	2004
Chrysoula Leontiou Kathryn Gilroy Gary Watters Professor Caroline Austin	Identifying drug-resistant mutations in human topoisomerase II beta using a forced molecular evolution approach	2004
Chrysoula Leontiou Professor Jeremy Lakey Professor Caroline Austin	Mutation E522K in human DNA topoisomerase IIβ confers resistance to methyl N-(4′-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4′-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide	2004
Dr Elaine Willmore Professor Caroline Austin	Alchemix: A novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer	2003
Professor Caroline Austin Professor Michael Taggart	Inhibitors of Actin Filament Polymerisation Attenuate Force but not Global [Ca2+]i in Isolated Pressurised Resistance Arteries	2003
Chrysoula Leontiou Professor Robert Lightowlers Professor Jeremy Lakey Professor Caroline Austin	Kinetic analysis of human topoisomerase IIα and β DNA binding by surface plasmon resonance	2003
Professor Caroline Austin	Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents	2003
Professor Michael Taggart Professor Caroline Austin	The acute effects of oestrogen receptor subtype-specific agonists on vascular contractility	2003
Dr Elaine Willmore Professor Jeremy Lakey Professor Caroline Austin	Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIß: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability	2002
Andrew Jobson Dr Elaine Willmore Dr Michael Tilby Professor Caroline Austin	Characterisation of the roles of Topoisomerase I and II in the mechanism of action of novel anti-tumour agents XR11576 (MLN576) and XR5944 (MLN944)	2002
Dr Elaine Willmore Fiona Errington Dr Michael Tilby Professor Caroline Austin	Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells	2002
Dr Elaine Willmore Dr Michael Tilby Professor Caroline Austin Professor barbara Durkacz	Potentiation of topoisomerase II poison cytotoxicity in the K562 human leukaemia cell line by the novel DNA-dependent protein kinase inhibitor NU7026	2002
Dr Emma Meczes Professor Andrew Pearson Professor Caroline Austin Dr Michael Tilby	Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin	2002
Dr Elaine Willmore Professor Caroline Austin Professor Nicola Curtin	The role of poly(ADP-ribose) polymerase-1 (PARP-1) in the cellular response to topoisomerase I poisons	2002
Professor Caroline Austin	The role of topoisomerase II in the excision of DNA loop domains during apoptosis	2002
Dr Kay Padget Professor Caroline Austin	Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis	2001
Dr Kay Padget Dr Michael Tilby Professor Caroline Austin	An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells	2000
Dr Kay Padget Professor Andrew Pearson Dr Michael Tilby Professor Caroline Austin	Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining)	2000
Dr Trevor Jowett Professor Caroline Austin	Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development	2000
Dr Emma Meczes Professor Caroline Austin	Mutagenesis of E477 or K505 in the B' domain of human topoisomerase IIβ increases the requirement for magnesium ions during strand passage	2000
Dr Sheila Patel Professor Caroline Austin	Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase II alpha	2000
Dr Kay Padget Professor Andrew Pearson Professor Caroline Austin	Quantitation of DNA topoisomerase II alpha and beta in human leukaemia cells by immunoblotting	2000
Dr Kay Padget Professor Andrew Pearson Professor Caroline Austin	Quantitation of DNA topoisomerase IIalpha and beta in human leukaemia cells by immunoblotting	2000
Dr Emma Meczes Dr Margaret Rogers Professor Caroline Austin	Carbamate analogues of amsacrine active against non-cycling cells: Relative activity against topoisomerases IIα and β	1999
Professor Caroline Austin	Cell cycle-dependent expression and subcellular localization of human barren-1 (HCAP-H).	1999
Professor Caroline Austin	Human DNA topoisomerase II beta binds and cleaves four-way junction DNA in vitro	1999
Professor Caroline Austin	Molecular cloning and characterization of the human topoisomerase II alpha and II beta genes: evidence for isoform evolution through gene duplication	1999
Fiona Errington Dr Elaine Willmore Dr Michael Tilby Professor Caroline Austin	Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: Analysis of cytotoxicity and cleavable complex formation	1999
Fiona Errington Dr Trevor Jowett Professor Caroline Austin	sox30: a novel zebrafish sox gene expressed in a restricted manner at the midbrain-hindbrain boundary during neurogenesis	1999
Dr Emma Meczes Professor Caroline Austin Professor Andrew Pearson Dr Michael Tilby	Synergy studies of etoposide and cisplatin action in neuroblastoma cell lines	1999
Dr Elaine Willmore Dr Adrian Frank Dr Kay Padget Dr Michael Tilby Professor Caroline Austin et al.	Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique	1998
Dr Ian Cowell Dr Elaine Willmore Dr David Allen Chalton Professor Caroline Austin	Nuclear distribution of human DNA topoisomerase IIβ: A nuclear targeting signal resides in the 116-residue C-terminal tail	1998
Dr Emma Meczes Professor Caroline Austin	103 Site-directed mutagenesis of human DNA topoisomerase IIβ	1997
Dr Ian Cowell Professor Caroline Austin	cDNA library protocols	1997
Dr Emma Meczes Dr Margaret Rogers Professor Caroline Austin	Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2β construct allows the study of topoisomerase IIβ inhibitors in yeast	1997
Dr Ian Cowell Professor Caroline Austin	Self-association of chrome domain peptides	1997
Dr Ian Cowell Professor Caroline Austin	Self-association of chromo domain peptides	1997
Dr Elaine Willmore Dr Emma Meczes Professor Caroline Austin	Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms α and β	1996
Dr Elaine Willmore Professor Caroline Austin	Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIα (p170) and IIβ (p180)	1996
Professor Caroline Austin Dr Elaine Willmore	Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity	1996
Professor Caroline Austin Dr Elaine Willmore	Expression, domain structure and enzymatic properties of an active recombinant human DNA topoisomerase II beta	1995