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Browsing publications by Emerita Professor Caroline Austin

Newcastle AuthorsTitleYearFull text
Emerita Professor Caroline Austin
Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection2025
Dr Ian Cowell
Elise Ling
Emerita Professor Caroline Austin
Topoisomerase II DNA Cleavage Assay Using Fluorescently Labelled Double-Stranded Oligonucleotides2025
Mushtaq Khazeem
Emerita Professor Caroline Austin
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage2024
Dr Ian Cowell
Emerita Professor Caroline Austin
Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti-cancer drug etoposide2024
Dr Ian Cowell
Emerita Professor Caroline Austin
DNA fragility at the KMT2A/MLL locus: insights from old and new technologies2023
Dr Ian Cowell
John Casement
Emerita Professor Caroline Austin
To Break or Not to Break: The Role of TOP2B in Transcription2023
Elise Ling
Dr Arnaud Basle
Dr Ian Cowell
Professor Bert van den Berg
Emerita Professor Caroline Austin
A comprehensive structural analysis of the ATPase domain of Human DNA topoisomerase II Beta bound to AMPPNP, ADP and the bisdioxopiperazine, ICRF1932022
Dr Ian Cowell
Emerita Professor Caroline Austin
Disease-associated Mutations in Topoisomerase IIβ Result in Defective NK cells2022
Emerita Professor Caroline Austin
Human topoisomerases and their roles in genome stability and organization2022
Rebecca Swan
Dr Ian Cowell
Emerita Professor Caroline Austin
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes2022
Mushtaq Khazeem
John Casement
Dr Niall Kenneth
Jade McGow
Dr Ian Cowell
et al.		TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA‑Induced Differentiation of SH‑SY5Y Neuroblastoma Cells2022
Dr Katja Menger
Dr James Chapman
Mushtaq Khazeem
Dr Dasha Deen
John Casement
et al.		Two type I topoisomerases maintain DNA topology in human mitochondria2022
Rebecca Swan
Dr Ian Cowell
Emerita Professor Caroline Austin
A role for VCP/p97 in the processing of drug-stabilized TOP2-DNA covalent complexes2021
Emerita Professor Caroline Austin
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions2021
Emerita Professor Caroline Austin
Dr Ian Cowell
Mushtaq Khazeem
Dawn Lok
Huei Teng Ng
TOP2B’s contributions to transcription2021
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