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Lookup NU author(s): Professor Tiago OuteiroORCiD, Dr David KossORCiD, Dr Daniel ErskineORCiD, Dr Lauren WalkerORCiD, Abishek Umashankar, Professor David BurnORCiD, Dr Paul Donaghy, Dr Christopher Morris, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD, Professor Johannes Attems, Professor Ian McKeith
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.
Author(s): Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn DJ, Donaghy P, Morris CM, Taylor JP, Thomas AJ, Attems J, McKeith IG
Publication type: Article
Publication status: Published
Journal: Molecular Neurodegeneration
Year: 2019
Volume: 14
Online publication date: 21/01/2019
Acceptance date: 08/01/2019
Date deposited: 22/01/2019
ISSN (electronic): 1750-1326
Publisher: BioMed Central Ltd.
URL: https://doi.org/10.1186/s13024-019-0306-8
DOI: 10.1186/s13024-019-0306-8
PubMed id: 30665447
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