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Dementia with Lewy bodies: an update and outlook

Lookup NU author(s): Professor Tiago OuteiroORCiD, Dr David KossORCiD, Dr Daniel ErskineORCiD, Dr Lauren WalkerORCiD, Abishek -, Professor David Burn, Dr Paul Donaghy, Dr Christopher Morris, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD, Professor Johannes Attems, Professor Ian McKeith

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.


Publication metadata

Author(s): Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn DJ, Donaghy P, Morris CM, Taylor JP, Thomas AJ, Attems J, McKeith IG

Publication type: Article

Publication status: Published

Journal: Molecular Neurodegeneration

Year: 2019

Volume: 14

Online publication date: 21/01/2019

Acceptance date: 08/01/2019

Date deposited: 22/01/2019

ISSN (electronic): 1750-1326

Publisher: BioMed Central Ltd.

URL: https://doi.org/10.1186/s13024-019-0306-8

DOI: 10.1186/s13024-019-0306-8

PubMed id: 30665447


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Funding

Funder referenceFunder name
CNMPB
G0400074
NIHR

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