Browse by author
Lookup NU author(s): David Hamilton, Dr Meryl Lusher, Dr Janet Lindsey, Professor David Ellison, Professor Steven CliffordORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
To investigate the role of aberrant epigenetic events in ependymoma and identify critical genes in its pathogenesis, the methylation status of nine tumour suppressor genes (TSGs: p14(ARF), p15(INK4B), p16(INK4A), CASP8, MGMT, TIMP3, TP73, RB1 and RASSF1A) was assessed. Extensive hypermethylation across the RASSF1A CpG island was detected frequently in ependymomas of all clinical and pathological disease subtypes (86% of cases, n=35), but not in non-neoplastic brain tissues (n=6). Less frequent methylation was observed for CASP8, MGMT and TP73 (5-20%). The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease. © 2004 Elsevier Ireland Ltd. All rights reserved.
Author(s): Hamilton D, Lusher M, Lindsey J, Ellison D, Clifford SC
Publication type: Article
Publication status: Published
Journal: Cancer Letters
Year: 2005
Volume: 227
Issue: 1
Pages: 75-81
ISSN (print): 0304-3835
ISSN (electronic): 1872-7980
Publisher: Elsevier Ireland Ltd
URL: http://dx.doi.org/10.1016/j.canlet.2004.11.044
DOI: 10.1016/j.canlet.2004.11.044
PubMed id: 16051033
Altmetrics provided by Altmetric