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Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma

Lookup NU author(s): David Hamilton, Dr Meryl Lusher, Dr Janet Lindsey, Professor David Ellison, Professor Steven Clifford

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Abstract

To investigate the role of aberrant epigenetic events in ependymoma and identify critical genes in its pathogenesis, the methylation status of nine tumour suppressor genes (TSGs: p14(ARF), p15(INK4B), p16(INK4A), CASP8, MGMT, TIMP3, TP73, RB1 and RASSF1A) was assessed. Extensive hypermethylation across the RASSF1A CpG island was detected frequently in ependymomas of all clinical and pathological disease subtypes (86% of cases, n=35), but not in non-neoplastic brain tissues (n=6). Less frequent methylation was observed for CASP8, MGMT and TP73 (5-20%). The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease. © 2004 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Hamilton D, Lusher M, Lindsey J, Ellison D, Clifford SC

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2005

Volume: 227

Issue: 1

Pages: 75-81

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.canlet.2004.11.044

DOI: 10.1016/j.canlet.2004.11.044

PubMed id: 16051033


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