Toggle Main Menu Toggle Search

Open Access padlockePrints

Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma

Lookup NU author(s): David Hamilton, Dr Meryl Lusher, Dr Janet Lindsey, Professor David Ellison, Professor Steven CliffordORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

To investigate the role of aberrant epigenetic events in ependymoma and identify critical genes in its pathogenesis, the methylation status of nine tumour suppressor genes (TSGs: p14(ARF), p15(INK4B), p16(INK4A), CASP8, MGMT, TIMP3, TP73, RB1 and RASSF1A) was assessed. Extensive hypermethylation across the RASSF1A CpG island was detected frequently in ependymomas of all clinical and pathological disease subtypes (86% of cases, n=35), but not in non-neoplastic brain tissues (n=6). Less frequent methylation was observed for CASP8, MGMT and TP73 (5-20%). The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease. © 2004 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Hamilton D, Lusher M, Lindsey J, Ellison D, Clifford SC

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2005

Volume: 227

Issue: 1

Pages: 75-81

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.canlet.2004.11.044

DOI: 10.1016/j.canlet.2004.11.044

PubMed id: 16051033


Altmetrics

Altmetrics provided by Altmetric


Share