Publications by Dr Julie Tucker - ePrints

Browsing publications by Dr Julie Tucker.

Newcastle Authors	Title	Year
Judith Unterlass Dr Arnaud Basle Dr Julie Tucker Dr Celine Cano Professor Martin Noble et al.	Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer	2018
Dr Julie Tucker	Keep it together: restraints in crystallographic refinement of macromolecule-ligand complexes	2017
Judith Unterlass Dr Arnaud Basle Dr Julie Tucker Dr Celine Cano Professor Martin Noble et al.	Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)	2017
Dr Julie Tucker Professor Keith Jones	Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the Heat Shock Factor (HSF1) stress pathway and CDK9	2016
Dr Julie Tucker	Discovery of a novel allosteric inhibitor binding site in ERK5: comparison with canonical kinase hinge ATP-binding site	2016
Dr Julie Tucker	First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib	2016
Dr Julie Tucker	Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation	2015
Dr Julie Tucker	Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase	2015
Dr Julie Tucker	Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors	2015
Dr Julie Tucker	FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.	2014
Dr Julie Tucker	Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4	2014
Dr Julie Tucker	Aminopyrazinamides: Novel and Specific GyrB Inhibitors that Kill Replicating and Nonreplicating Mycobacterium tuberculosis	2013
Dr Julie Tucker	Thiazolepyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B	2013
Dr Julie Tucker	Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation	2012
Dr Julie Tucker	Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases	2012
Dr Julie Tucker	Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3ß (GSK3ß) Inhibitors for Alzheimer's Disease: Design, Synthesis and Characterization of Pyrazines	2012
Dr Julie Tucker	Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives	2012
Dr Julie Tucker Professor Martin Noble Professor Jane Endicott	How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A	2007
Professor Jane Endicott Professor Martin Noble Dr Julie Tucker	Cyclin-dependent kinases: inhibition and substrate recognition	1999