Publications by Dr Paul Smith - ePrints

Browsing publications by Dr Paul Smith.

Newcastle Authors	Title	Year
Dr Joanna Elson Dr Paul Smith	Heterologous Inferential Analysis (HIA) as a Method to Understand the Role of Mitochondrial rRNA Mutations in Pathogenesis	2015
Dr Joanna Elson Dr Paul Smith Professor Laura Greaves Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al.	The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease	2015
Dr Veronika Boczonadi Dr Paul Smith Dr Angela Pyle Dr Aurora Gomez Duran Professor Patrick Chinnery et al.	Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency	2013
Dr Veronika Boczonadi Dr Paul Smith Professor Patrick Chinnery Professor Rita Horvath	Defective thiolation impairs mitochondrial translation offering a therapy approach in reversible infantile respiratory chain deficiency	2013
Dr Paul Smith Dr Joanna Elson Professor Laura Greaves Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al.	The role of the mitochondrial ribosome in human disease: Searching for mutations in 12S mitochondrial rRNA with high disruptive potential	2013
Dr Veronika Boczonadi Dr Paul Smith Kamil Sitarz Professor Zofia Chrzanowska-Lightowlers Professor Robert Lightowlers et al.	Studying the molecular basis of the reversibility in infantile reversible cytochrome c oxidase deficiency	2012
Dr Paul Smith Professor Robert Lightowlers	Altering the balance between healthy and mutated mitochondrial DNA	2011
Ricarda Richter Dr Joanna Rorbach Aleksandra Pajak Dr Paul Smith Professor Robert Lightowlers et al.	A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome	2010
Professor Rita Horvath Dr Helen Tuppen Professor Gavin Hudson Dr Angela Pyle Dr Paul Smith et al.	Infantile reversible COX deficiency myopathy caused by the m.14674T > C mutation in mt-tRNA(Glu) in a German family	2010
Sven Dennerlein Dr Paul Smith Dr Agata Rozanska Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al.	Knowing when to stop - human mitochondrial translation termination	2010
Professor Rita Horvath Dr Helen Tuppen Professor Gavin Hudson Dr Angela Pyle Dr Paul Smith et al.	Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy	2009
Professor Zofia Chrzanowska-Lightowlers Dr Richard Temperley Dr Paul Smith Professor Robert Lightowlers	Functional polypeptides can be synthesized from human mitochondrial transcripts lacking termination codons	2004
Dr Paul Smith Dr Gunther Ross Professor Robert Taylor Emeritus Professor Doug Turnbull Professor Robert Lightowlers et al.	Bridging PNAs can bind preferentially to a deleted mitochondrial DNA template but replication by mitochondrial DNA polymerase γ in vitro is not impaired	2003
Professor Robert Lightowlers Dr Paul Smith	Specific targeting of a DNA-alkylating reagent to mitochondria: Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide	2003
Dr Gunther Ross Dr Paul Smith Emeritus Professor Doug Turnbull Professor Robert Lightowlers	Synthesis of trifunctional PNA-benzophenone derivatives for mitochondrial targeting, selective DNA binding, and photo-cross-linking	2003
Dr Paul Smith Dr Gunther Ross Dr Theresa Wardell Professor Robert Taylor Emeritus Professor Doug Turnbull et al.	The use of PNAs and their derivatives in mitochondrial gene therapy	2003
Professor Robert Taylor Dr Theresa Wardell Dr Paul Smith Emeritus Professor Doug Turnbull Professor Robert Lightowlers et al.	An antigenomic strategy for treating heteroplasmic mtDNA disorders	2001
Linda Smith Dr Paul Smith	Behavioural treatment of urinary incontinence and encopresis in children with learning disabilities: transfer of stimulus control	2000