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Browsing publications by Emeritus Professor Barbara Durkacz.

Newcastle AuthorsTitleYearFull text
Emily Mould
Philip Berry
Dr David Jamieson
Dr Chris Hill
Dr Celine Cano
et al.
Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity2014
Emily Mould
Philip Berry
Dr David Jamieson
Dr Chris Hill
Niu Tan
et al.
The DNA-PK inhibitor, NU7441, sensitises cancer cells to microtubule-targeting agents and modulates vincristine efflux in multidrug resistant cells2013
Dr Jill Hunter
Dr Elaine Willmore
Professor Julie Irving
Dr Stephany Veuger
Emeritus Professor Barbara Durkacz
et al.
NF-kappa B mediates radio-sensitization by the PARP-1 inhibitor, AG-0146992012
Dr Susan Tudhope
Dr Evan Mulligan
Dr Jill Hunter
Dr Helen Marr
Emeritus Professor Barbara Durkacz
et al.
P B S-1086, a "Pan-Rel" Inhibitor, Decreases Viability of Chronic Lymphocytic Leukemia Cells2012
Dr sarah Johnson
Clark Crawford
Dr Evan Mulligan
Dr Jonathan Wallis
Dr Tryfonia Mainou-Fowler
et al.
Mitoxantrone in combination with an inhibitor of DNA-dependent kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia2011
Dr Stephany Veuger
Emeritus Professor Barbara Durkacz
Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-kappa B activation2011
Dr Elaine Willmore
Dr Evan Mulligan
Dr Sarah Elliott
Emeritus Professor Barbara Durkacz
ATM Mutant Chronic Lymphocytic Leukaemia Cells are Chemosensitized by Inhibition of DNA Dependent Protein Kinase2010
Dr sarah Johnson
Dr Tryfonia Mainou-Fowler
Emeritus Professor Barbara Durkacz
Dr Elaine Willmore
Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: A potential therapy for poor risk B-cell chronic lymphocytic leukaemia2010
Dr Evan Mulligan
Arabella Baird
Dr Jonathan Wallis
Dr Stephany Veuger
Emeritus Professor Barbara Durkacz
et al.
Relationships Between Aberrant Activity of the NF-kappa B Subunits and Outcome In Chronic Lymphocytic Leukemia: The Dual Role of DNA Damage Sensor Enzymes2010
Dr Stephany Veuger
Emeritus Professor Barbara Durkacz
Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance2009
Dr Elaine Willmore
Dr sarah Johnson
Dr Tryfonia Mainou-Fowler
Professor Graham Jackson
Dr Celine Cano
et al.
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia2008
Dr Elaine Willmore
Dr sarah Johnson
Clark Crawford
Dr Tryfonia Mainou-Fowler
Professor Graham Jackson
et al.
DNA-Dependent Protein Kinase Is a Therapeutic Target in Poor Prognosis B-Cell Chronic Lymphocytic Leukemia2008
Dr Ian Cowell
Dr Nicola Sunter
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
Dr Michael Tilby
et al.
γH2AX foci form preferentially in euchromatin after ionising-radiation2007
Dr Elaine Willmore
Professor Graham Jackson
Dr Tryfonia Mainou-Fowler
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
et al.
Sensitisation of B-CLL cells to chlorambucil and fludarabine via inhibition of the DNA damage sensor proteins, DNA-PK and ATM2006
Dr Elaine Willmore
Dr Tryfonia Mainou-Fowler
Professor Graham Jackson
Emeritus Professor Barbara Durkacz
Targeting DNA-PK and ATM increases sensitivity to chlorambucil and fludarabine in chemoresistant and p53-defective B-CLL cells2006
Dr Ian Cowell
Emeritus Professor Barbara Durkacz
Dr Michael Tilby
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated2005
Dr Elaine Willmore
Dr Nicola Sunter
Dr Michael Tilby
Professor Graham Jackson
Professor Caroline Austin
et al.
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia2004
Dr Christopher Calabrese
Michael Batey
Professor Alan Calvert
Emeritus Professor Barbara Durkacz
Suzanne Kyle
et al.
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG143612004
Dr Stephany Veuger
Professor Nicola Curtin
Emeritus Professor Barbara Durkacz
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair2004
Dr Stephany Veuger
Professor Nicola Curtin
Emeritus Professor Barbara Durkacz
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair2004
Dr Stephany Veuger
Emeritus Professor Barbara Durkacz
Improving breast cancer treatment using novel poly(ADP-ribose)2004
Professor Nicola Curtin
Lan Wang
Suzanne Kyle
Dr Christine Arris
Emeritus Professor Barbara Durkacz
et al.
Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells2004
Dr Christopher Calabrese
Michael Batey
Huw Thomas
Emeritus Professor Barbara Durkacz
Lan Wang
et al.
Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies2003
Dr Stephany Veuger
Professor Nicola Curtin
Emeritus Professor Barbara Durkacz
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-12003
Dr Elaine Willmore
Dr Michael Tilby
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
Potentiation of topoisomerase II poison cytotoxicity in the K562 human leukaemia cell line by the novel DNA-dependent protein kinase inhibitor NU70262002
Professor Nicola Curtin
Dr Stephen Barton
Michael Batey
Dr Christopher Calabrese
Professor Alan Calvert
et al.
Anti-cancer chemosensitization in vitro and in vivo by a novel potent poly(ADP-ribose) polymerase (PARP1) inhibitor, TBI-361.2001
Dr Stephany Veuger
Emeritus Professor Barbara Durkacz
Professor Bernard Golding
Professor Roger Griffin
Professor Herbie Newell
et al.
Radiosensitization by novel inhibitors of PARP, PI, and DNA-PK, NU7026, in vitro2001
Dr Paul Jowsey
Gillian Farnie
Emeritus Professor Barbara Durkacz
Professor John Lunec
The dependence of p63 induction and activity on poly (ADP-ribose) polymerase-12001
Professor Nicola Curtin
Professor Alan Calvert
Emeritus Professor Barbara Durkacz
Professor Roger Griffin
Professor Bernard Golding
et al.
Chemopotentiation studies with two classes of potent (polyADP-ribose) polymerase (PARP) inhibitors in human lung and colon carcinoma cell lines.2000
Suzanne Kyle
Emeritus Professor Barbara Durkacz
Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin2000
Lan Wang
Suzanne Kyle
Alex White
Professor Alan Calvert
Professor Nicola Curtin
et al.
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines2000
Suzanne Kyle
Emeritus Professor Barbara Durkacz
Cytotoxic mechanism of the protein kinase inhibitor wortmannin in ionising radiation and etoposide treated cells1999
Suzanne Kyle
Emeritus Professor Barbara Durkacz
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage1999
Professor Nicola Curtin
Professor Alan Calvert
Emeritus Professor Barbara Durkacz
Professor Herbie Newell
Potentiation of temozolomide and topotecan cytotoxicity by PARP inhibitors in a panel of human cancer cell lines.1999
Professor Nicola Curtin
Suzanne Kyle
Lan Wang
Emeritus Professor Barbara Durkacz
Professor Roger Griffin
et al.
Potentiation of temozolomide and topotecan growth inhibition by novel potent benzimidazole poly(ADP-ribose) polymerase (PARP) inhibitors1999
Suzanne Kyle
Emeritus Professor Barbara Durkacz
Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: Effects on NAD metabolism and DNA repair1997
Suzanne Kyle
Emeritus Professor Barbara Durkacz
Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells1996
Professor Roger Griffin
Professor Nicola Curtin
Professor Herbie Newell
Professor Bernard Golding
Emeritus Professor Barbara Durkacz
et al.
The Role of Inhibitors of Poly(Adp-Ribose) Polymerase as Resistance-Modifying Agents in Cancer-Therapy1995
Dr Elaine Willmore
Emeritus Professor Barbara Durkacz
The effects of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elution.1994
Dr Elaine Willmore
Emeritus Professor Barbara Durkacz
Cytotoxic mechanisms of 5-fluoropyrimidines: Relationships with poly(ADP-ribose) polymerase activity, DNA strand breakage and incorporation into nucleic acids1993
Emeritus Professor Barbara Durkacz
Professor John Lunec
Professor Michael Griffin

Murine Melanoma Cell-Differentiation and Melanogenesis Induced by Poly(ADP-Ribose) Polymerase Inhibitors

1992
Emeritus Professor Barbara Durkacz
3-Aminobenzamide enhances base analog cytotoxicity by a mechanism independent of an inhibition of DNA repair1990
Dr Elaine Willmore
Emeritus Professor Barbara Durkacz
Correlation of enhanced 6-mercaptopurine cytotoxicity with increased phosphoribosylpyrophosphate levels in Chinese hamster ovary cells treated with 3-aminobenzamide1990
Emeritus Professor Barbara Durkacz
Marked enhancement of base analog cyto-toxicity by 3-aminobenzamide: correlation with increased phosphotibosylpyrophospahte levels and augmented base salvage1989
Emeritus Professor Barbara Durkacz
Adenosine-diphosphoribosyltransferase inhibitors can protect against or potentiate the cytotoxicity of S-phase acting drugs1988
Emeritus Professor Barbara Durkacz
Synergistic enhancement of 6-thioguanine cytotoxicity by ADP-ribosyltransferase inhibitors1988
Emeritus Professor Barbara Durkacz
ADP-ribosyl transferase inhibitors potentiate the cytotoxicity of base, but not nucleotide, analogs1987
Emeritus Professor Barbara Durkacz
Inhibitors of ADP-ribosyl transferase protect against the cytotoxocity of S-phase acting drugs1986