Toggle Main Menu Toggle Search

Open Access padlockePrints

Browsing publications by Professor Catharien Hilkens.

Newcastle AuthorsTitleYearFull text
Sophie Reay
Emma Jackson
Dr Ana Ferreira-Duarte
Professor Catharien Hilkens
Dr Katarina Novakovic
et al.
In Vitro Evaluation of the Biodegradability of Chitosan-Genipin Hydrogels2022
Professor John Isaacs
Sarah Brockbank
Dr Ayako Pedersen
Professor Catharien Hilkens
Dr Amy Anderson
et al.
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients2022
Dr Fiona Rayner
Dr Amy Anderson
Dr Ken Baker
Professor Christopher Buckley
Dr Bernard Dyke
et al.
BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study2021
Leonie Schittenhelm
Dr Arthur Pratt
Professor Catharien Hilkens
Dendritic cell integrin expression patterns regulate inflammation in the rheumatoid arthritis joint2021
Professor Catharien Hilkens
Professor Paul Garside
Preclinical models of arthritis for studying immunotherapy and immune tolerance2021
Dr Amanda Thomson
Professor Catharien Hilkens
Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis?2021
Dr Matthew Wood
Adam Leckenby
Dr Gary Reynolds
Dr Rachel Spiering
Dr Arthur Pratt
et al.
Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients2019
Dr Rachel Spiering
Professor Catharien Hilkens
Matured tolerogenic dendritic cells effectively inhibit autoantigen specific CD4+ T cells in a murine arthritis model2019
Dr Rachel Spiering
Matthew Wood
Anshor Fath
Oliver Eltherington
Dr Amy Anderson
et al.
Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis2019
Professor Catharien Hilkens
Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective2019
Dr Rachel Spiering
Professor John Isaacs
Professor Catharien Hilkens
Dr Phillip Lord
Minimum information about T regulatory cells: A step toward reproducibility and standardization2018
Dr Faye Cooles
Dr Amy Anderson
Andrew Skelton
Dr Arthur Pratt
Professor Iain McInnes
et al.
Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis2018
Dr Rachel Spiering
Professor John Isaacs
Professor Catharien Hilkens
Targeting of tolerogenic dendritic cells towards heat-shock proteins: A novel therapeutic strategy for autoimmune diseases?2018
Aisha Blfgeh
Dr Jennifer Warrender
Professor Catharien Hilkens
Dr Phillip Lord
A document-centric approach for developing the tolAPC ontology2017
Dr Gillian Bell
Dr Amy Anderson
Julie Diboll
Oliver Eltherington
Dr Rachel Harry
et al.
Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis2017
Professor Catharien Hilkens
Cell-based tolerogenic therapy, experience from animal models of multiple sclerosis, type 1 diabetes and rheumatoid arthritis2017
Dr Faye Cooles
Dr Amy Anderson
Dr Dennis Lendrem
Julie Norris
Dr Arthur Pratt
et al.
The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy2017
Dr Amy Anderson
Dr David Swan
Oliver Eltherington
Dr Arthur Pratt
Dr Gary Reynolds
et al.
Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T-cells partly via TGF-β12017
Joseph Cowell
Matthew Buck
Rebecca Clarke
Professor Waldemar Vollmer
Dr Daniela Vollmer
et al.
Traceless-Cleavage of Protein-Biotin Conjugates Under Biologically-Compatible Conditions2017
Dr Tom Clifford
Matt Wood
Philip Stocks
Professor Emma Stevenson
Professor Catharien Hilkens
et al.
T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans2017
Leonie Schittenhelm
Professor Catharien Hilkens
β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function2017
Aisha Blfgeh
Dr Jennifer Warrender
Professor Catharien Hilkens
Dr Phillip Lord
A document-centric approach for developing the tolAPC Ontology2016
Dr Katherine Crossland
Dr Mario Abinun
Professor Timothy Cheetham
Professor Simon Pearce
Professor Catharien Hilkens
et al.
AIRE is not essential for the induction of human tolerogenic dendritic cells2016
Professor Ioakim Spyridopoulos
Dr Carmen Martin-Ruiz
Professor Catharien Hilkens
Mohammad Yadegarfar
Professor John Isaacs
et al.
CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study2016
Professor Catharien Hilkens
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4+ T Cells2016
Dr Phillip Lord
Dr Rachel Spiering
Dr Amy Anderson
Julie Diboll
Professor Lindsay Marshall
et al.
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies2016
Dr Phillip Lord
Professor Catharien Hilkens
Ontology in Immunology2016
Chris Tibbitt
Dr Jane Falconer
Dr Jeroen Stoop
Emeritus Professor John Robinson
Professor Catharien Hilkens
et al.
Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance2016
Dr Gary Reynolds
Dr Arthur Pratt
Dr David Coady
Dr Graham Raftery
Dr Alice Lorenzi
et al.
Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis2016
Professor Catharien Hilkens
Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features2016
Dr Gary Reynolds
Dr Paul Milne
Dr Venetia Bigley
Professor Matthew Collin
Professor John Isaacs
et al.
Use of the dendritic cell marker, B and T lymphocyte attenuator, to identify functionally distinct subsets of human CD1c+ dendritic cells2016
Professor Catharien Hilkens
Dr Phillip Lord
Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort2015
Professor Catharien Hilkens
Hurdles in therapy with regulatory T cells2015
Dr Faye Cooles
Dr Amy Anderson
Professor Catharien Hilkens
Professor John Isaacs
The Interferon Gene Signature in Early Rheumatoid Arthritis Demonstrates No Significant Association with Disease Activity2015
Harriet Purvis
Dr Amy Anderson
Professor David Young
Professor John Isaacs
Professor Catharien Hilkens
et al.
A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses2014
Dr Gillian Bell
Dr Amy Anderson
Julie Diboll
Dr Rachel Harry
Professor Elaine McColl
et al.
Autologous Tolerogenic Dendritic Cells for Rheumatoid and Inflammatory Arthritis.2014
Dr Gillian Bell
Dr Amy Anderson
Dr Rachel Harry
Julie Diboll
Professor Elaine McColl
et al.
Autologous tolerogenic dendritic cells in rheumatoid and inflammatory arthritis2014
Dr Nicola Maney
Dr Gary Reynolds
Dr Anja Krippner-Heidenreich
Professor Catharien Hilkens
Dendritic Cell Maturation and Survival Are Differentially Regulated by TNFR1 and TNFR22014
Dr Gary Reynolds
Dr Faye Cooles
Professor John Isaacs
Professor Catharien Hilkens
Emerging immunotherapies for rheumatoid arthritis2014
Dr Katherine Crossland
Professor Simon Pearce
Dr Mario Abinun
Professor Timothy Cheetham
Professor Catharien Hilkens
et al.
Role of Aire in the Induction of Human Tolerogenic Dendritic Cells2014
Dr Gillian Bell
Dr Amy Anderson
Julie Diboll
Dr Rachel Harry
Professor Elaine McColl
et al.
Autologous Tolerogenic Dendritic Cells In Rheumatoid and Inflammatory Arthritis2013
Dr Naomi McGovern
Dr Laura Jardine
Harriet Purvis
Professor Catharien Hilkens
Professor Matthew Collin
et al.
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses2013
Dr Jeroen Stoop
Chris Tibbitt
Professor John Robinson
Professor Catharien Hilkens
The choice of adjuvant determines the cytokine profile of T cells in proteoglycan-induced arthritis but does not influence disease severity2013
Professor Catharien Hilkens
Professor John Isaacs
Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?2013
Dr Arthur Pratt
Dr Daniel Swan
Dr Sarah Richardson
Gillian Wilson
Professor Catharien Hilkens
et al.
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease2012
Dr Gillian Bell
Dr Amy Anderson
Dr Rachel Harry
Dr Jeroen Stoop
Professor Catharien Hilkens
et al.
Autologous tolerogenic dendritic cells in rheumatoid arthritis2012
Dr Joanna Collerton
Dr Carmen Martin-Ruiz
karen Davies
Professor Catharien Hilkens
Professor John Isaacs
et al.
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study2012
Harriet Purvis
Dr Amy Anderson
Professor Catharien Hilkens
Human T helper 17 responses: the effect of T-cell density2012
Dr Amy Anderson
Dr Alice Lorenzi
Dr Arthur Pratt
Thomas Wooldridge
Julie Diboll
et al.
Immunity 12 years after alemtuzumab in RA: CD5+ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses2012
Dr Arthur Pratt
Dr Sarah Richardson
Gillian Wilson
Professor Catharien Hilkens
Professor David Young
et al.
A Transcriptional Profile Present in CD4+T-Cells of Patients with Undifferentiated Arthritis Predicts the Future Development of Seronegative Rheumatoid Arthritis and Implicates IL-6 in Disease Evolution2011
Dr Carmen Martin-Ruiz
Emerita Professor Carol Jagger
Dr Andrew Kingston
Dr Joanna Collerton
Professor Mike Catt
et al.
Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study2011
Dr Jeroen Stoop
Professor John Robinson
Professor Catharien Hilkens
Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models?2011
Harriet Purvis
Dr Amy Anderson
Professor Catharien Hilkens
Human Th17 responses: the effect of T-cell density2011
Dr Malcolm Brodlie
Dr Michael McKean
Dr Amy Anderson
Professor Catharien Hilkens
Professor Andrew Fisher
et al.
Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease2011
Professor Catharien Hilkens
Professor John Isaacs
Development of dendritic cell-based immunotherapy for autoimmunity2010
Dr Rachel Harry
Dr Amy Anderson
Professor John Isaacs
Professor Catharien Hilkens
Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis2010
Harriet Purvis
Dr Jeroen Stoop
Professor Jelena Mann
Steven Woods
Anne Kozijn
et al.
Low strength T-cell activation promotes Th17 responses2010
Dr Jeroen Stoop
Professor Jelena Mann
Steven Woods
Anne Kozijn
Professor Sophie Hambleton
et al.
Low-strength T-cell activation promotes Th17 responses2010
Dr Arthur Pratt
Dr Daniel Swan
Dr Sarah Richardson
Professor Catharien Hilkens
Professor David Young
et al.
Peripheral Blood CD4 T Cell Gene Expression Profiles as Predictive Biomarkers in Early Arthritis2010
Dr Nicola Maney
Helen Baldwin
Dr Anja Krippner-Heidenreich
Professor Catharien Hilkens
Regulation of dendritic cell survival and function by tumour necrosis factor receptors 1 and 22010
Dr Jeroen Stoop
Professor John Robinson
Professor Catharien Hilkens
The choice of adjuvant determines the cytokine profile of T cells in proteoglycan induced arthritis2010
Dr Jeroen Stoop
Dr Rachel Harry
Dr Alexei von Delwig
Professor John Isaacs
Professor John Robinson
et al.
Therapeutic Effect of Tolerogenic Dendritic Cells in Established Collagen-Induced Arthritis Is Associated With a Reduction in Th17 Responses2010
Helen Baldwin
Dr Toshiko Ihara
Professor John Isaacs
Professor Catharien Hilkens
Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis2010
Dr Arthur Pratt
Dr Daniel Swan
Professor David Young
Professor Catharien Hilkens
Professor John Isaacs
et al.
A High-Throughput Transcriptomics Approach to Biomarker Discover in Early Arthritis2009
Dr Rachel Lakey
Emeritus Professor Drew Rowan
Professor John Isaacs
Emeritus Professor Tim Cawston
Professor Catharien Hilkens
et al.
A novel paradigm for dendritic cells as effectors of cartilage destruction2009
Dr Malcolm Brodlie
Professor Catharien Hilkens
Professor Christopher Ward
Airway epithelial cells as guardians of immune homeostasis?2009
Professor Christopher Ward
Julie Diboll
Professor Andrew Fisher
Dr Malcolm Brodlie
Dr James Lordan
et al.
Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells2009
Professor Muzlifah Haniffa
Dr Xiao Wang
Dr Venetia Bigley
Ian Dimmick
Dr Trevor Booth
et al.
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation2009
Dr Amy Anderson
Dr David Swan
Bethan Sayers
Dr Rachel Harry
Dr Angela Patterson
et al.
LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells2009
Dr Xiao Wang
Dr Udo Holtick
Professor Matthew Collin
Professor Graham Jackson
Professor Catharien Hilkens
et al.
Regulatory T-Cell Suppression of CD8+ T-Cell-Mediated Graft-Versus-Host Reaction Requires Their Presence During Priming2009
Dr Rachel Harry
Dr Amy Anderson
Dr Graham Raftery
Professor John Isaacs
Professor Catharien Hilkens
et al.
Development of clinical-grade tolerogenic dendritic cells for the treatment of rheumatoid arthritis2008
Dr Amy Anderson
Bethan Sayers
Professor Muzlifah Haniffa
Dr David Swan
Julie Diboll
et al.
Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells2008
Dr Jeroen Stoop
Dr Alexei von Delwig
Professor John Isaacs
Professor John Robinson
Professor Catharien Hilkens
et al.
Immunotherapy with tolerogenic dendritic cells inhibits the progression of collagen-induced arthritis2008
Dr Udo Holtick
Dr Scott Marshall
Dr Xiao Wang
Professor Catharien Hilkens
Professor Anne Dickinson
et al.
Impact of Psoralen/UVA-treatment on survival, activation, and immunostimulatory capacity of monocyte-derived dendritic cells2008
Dr Xiao Wang
Professor Muzlifah Haniffa
Dr Udo Holtick
Professor Catharien Hilkens
Professor Anne Dickinson
et al.
Naturally occurring regulatory T-cells suppress CD8+lymphocyte induced graft-versus-host reactions in an in vitro human GvHD model2008
Dr Amy Anderson
Bethan Sayers
Dr David Swan
Professor John Isaacs
Professor Catharien Hilkens
et al.
Tolerogenic dendritic cell therapy for rheumatoid arthritis2008
Professor Muzlifah Haniffa
Dr Xiao Wang
Dr Udo Holtick
Dr Michelle Rae
Professor John Isaacs
et al.
Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells2007
Bethan Sayers
Professor Muzlifah Haniffa
Julie Diboll
Professor John Isaacs
Professor Catharien Hilkens
et al.
Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties2007
Dr Xiao Wang
Dr Udo Holtick
Suzanne Alshemali
Professor Nick Reynolds
Professor Anne Dickinson
et al.
Human dermal broblasts ameliorate in vitro graft-versushost reactions and are functionally indistinguishable from bone marrow mesenchymal stromal cells2007
Dr Udo Holtick
Professor Catharien Hilkens
Dr Xiao Wang
Professor Anne Dickinson
Immature dendritic cells downregulate graft versus host reactions in the human skin explant model after co-culture with in vitro PUVA treated lymphocytes2007
Professor Muzlifah Haniffa
Dr Xiao Wang
Dr Udo Holtick
Dr Daniel Swan
Professor Anne Dickinson
et al.
Mesenchymal stem cells and fibroblasts have similar immunoregulatory properties in vitro but distinct gene expression profiles: Implications for cellular therapy2007
Dr Amy Anderson
Bethan Sayers
Julie Diboll
Professor John Isaacs
Professor Catharien Hilkens
et al.
Tolerogenic dendritic cells differentially modulate naïve and memory CD4+ T cells2007
Suzanne Alshemali
Dr Xiao Wang
Professor Catharien Hilkens
Professor Muzlifah Haniffa
Professor Anne Dickinson
et al.
Dermal dendritic cells but not Langerhans cells stimulate lymphocytes in an in vitro model of cutaneous graft-versus-host disease2006
Dr Alexei von Delwig
Professor Catharien Hilkens
Professor John Isaacs
Dr Helen Robertson
Professor John Robinson
et al.
Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice2006
Dr Udo Holtick
Dr Scott Marshall
Dr Xiao Wang
Professor Catharien Hilkens
Professor Anne Dickinson
et al.
Investigating the role of dendritic cells in extracorporeal photopheresis using an in vitro model2006
Dr Udo Holtick
Dr Scott Marshall
Professor Muzlifah Haniffa
Professor Catharien Hilkens
Dr Xiao Wang
et al.
Investigating the role of dendritic cells in extracorporeal photopheresis using an in vitro model2006
Dr Udo Holtick
Dr Scott Marshall
Dr Xiao Wang
Professor Catharien Hilkens
Professor Anne Dickinson
et al.
Modulation of dendritic cells in a human in vitro model of extracorporeal photopheresis2006
Dr Udo Holtick
Dr Scott Marshall
Dr Xiao Wang
Professor Catharien Hilkens
Professor Anne Dickinson
et al.
The fate of monocytes and monocyte-derived dendritic cells in an in vitro model of extracorporeal photopheresis2006
Dr Udo Holtick
Dr Scott Marshall
Professor Catharien Hilkens
Dr Xiao Wang
Professor Anne Dickinson
et al.
Examining the role of dendritic cells in extracorporeal photopheresis using an in vitro model2005
Bethan Sayers
Professor Muzlifah Haniffa
Julie Diboll
Professor John Isaacs
Professor Catharien Hilkens
et al.
Generation of dexamethasone and vitamin D3 treated human monocyte derived dendritic cells with tolerogenic properties2005
Professor Catharien Hilkens
Sustained IL-12 Signaling Is Required for Th1 Development2004
Professor Catharien Hilkens
α-type-1 polarized dendritic cells: A novel immunization tool with optimized CTL-inducing activity2004
Professor Catharien Hilkens
Differential Responses to IFN-α Subtypes in Human T Cells and Dendritic Cells2003
Professor Catharien Hilkens
Cell-type and Donor-specific Transcriptional Responses to Interferon-α: Use of customized gene arrays2002
Professor Catharien Hilkens
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp1302001
Professor Catharien Hilkens
How to deal with polarized Th2 cells: exploring the Achilles' heel2001
Professor Catharien Hilkens
IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression2001
Professor Catharien Hilkens
Atopic allergy: a failure of antigen-presenting cells to properly polarize helper T cells?2000
Professor Catharien Hilkens
Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells1999
Professor Catharien Hilkens
T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal1999
Professor Catharien Hilkens
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy1999
Professor Catharien Hilkens
High-level IL-12 production by human dendritic cells requires two signals1998
Professor Catharien Hilkens
Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation1998
Professor Catharien Hilkens
The role of antigen-presenting cells in the regulation of allergen-specific T cell responses1998
Professor Catharien Hilkens
Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses1997
Professor Catharien Hilkens
Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype1997
Professor Catharien Hilkens
IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells1997
Professor Catharien Hilkens
Accessory cell-derived IL-12 and prostaglandin E2 determine the IFN-gamma level of activated human CD4+ T cells1996
Professor Catharien Hilkens
Accessory cell-derived interleukin-12 and prostaglandin E2 determine the level of interferon-gamma produced by activated human CD4+ T cells1996
Professor Catharien Hilkens
CD30 expression does not discriminate between human Th1- and Th2-type T cells1996
Professor Catharien Hilkens
Lack of IL-12 signaling in human allergen-specific Th2 cells1996
Professor Catharien Hilkens
Modulation of T-cell cytokine secretion by accessory cell-derived products1996
Professor Catharien Hilkens
Production and modulation of T-cell cytokines in atopic allergy1996
Professor Catharien Hilkens
Reduced IL-12 production by monocytes upon ultraviolet-B irradiation selectively limits activation of T helper-1 cells1996
Professor Catharien Hilkens
Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit1996
Professor Catharien Hilkens
The role of accessory cell products in the regulation of T cell cytokine production1996
Professor Catharien Hilkens
Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-21995
Professor Catharien Hilkens
Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-41995
Professor Catharien Hilkens
Considerations in compiling a database of clinical test images1992