ePrints

Developmental cell programs are co-opted in inflammatory skin disease

Lookup NU author(s): Dr Gary ReynoldsORCiD, Dr Peter Vegh, Dr James Fletcher, Dr Beth Poyner, Dr Emily StephensonORCiD, Issac Goh, Dr Rachel Botting, Dr Bayanne Olabi, Dr Anna Dubois, David Dixon, Dr Kile GreenORCiD, Dan Maunder, Justin Engelbert, Dr Laura JardineORCiD, Claire Jones, Dave Horsfall, Jim McGrath, Dr Christopher Carey, Dr Dorin-Mirel Popescu, Dr Simone Webb, Dr Xiao WangORCiD, Dr David McDonald, Professor Andrew FilbyORCiD, Dr Akhtar Husain, Dr Jonathan Coxhead, Dr Roser Vento-Tormo, Dr Steven LisgoORCiD, Professor Jaume Bacardit, Professor Neil RajanORCiD, Professor Nick ReynoldsORCiD, Professor Muzlifah Haniffa

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© 2021 American Association for the Advancement of Science. All rights reserved.The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.

Publication metadata

Author(s): Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N, Olabi B, Dubois A, Dixon D, Green K, Maunder D, Engelbert J, Efremova M, Polański K, Jardine L, Jones C, Ness T, Horsfall D, McGrath J, Carey C, Popescu D-M, Webb S, Wang X-N, Sayer B, Park J-E, Negri VA, Belokhvostova D, Lynch MD, McDonald D, Filby A, Hagai T, Meyer KB, Husain A, Coxhead J, Vento-Tormo R, Behjati S, Lisgo S, Villani A-C, Bacardit J, Jones PH, O'Toole EA, Ogg GS, Rajan N, Reynolds NJ, Teichmann SA, Watt FM, Haniffa M

Publication type: Article

Publication status: Published

Journal: Science

Year: 2021

Volume: 371

Issue: 6527

Print publication date: 22/01/2021

Acceptance date: 02/04/2018

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science

URL: https://doi.org/10.1126/science.aba6500

DOI: 10.1126/science.aba6500

Altmetrics

Share