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Hypothesis: Epithelial-to-mesenchymal transition is a common cause of chronic allograft failure

Lookup NU author(s): Professor Christopher WardORCiD, Dr Helen Robertson, Dr Ian Forrest, Dr James Lordan, Denis Murphy, Professor John Dark, Emeritus Professor Nick Europe-Finner, Professor David Jones, Emeritus Professor John Kirby


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Renal, hepatic, and lung allografts are compromised by aggressively deteriorating function. This chronic process is produced by an overall burden of organ damage, but the pathophysiology remains poorly understood. Rates of chronic rejection in the lung, for example, have not substantially improved over the last decade, despite new immunosuppressive drugs and improvements in surgical procedure. We present a hypothesis that epithelial-to-mesenchymal transition is a common cause of chronic allograft failure. Research in this area may provide insights into chronic rejection of kidney, liver, and lung allografts that impact on future therapeutic strategies. © 2005 by Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Ward C, Robertson H, Forrest IA, Lordan J, Murphy D, Dark JH, Corris PA, Jones DEJ, Kirby JA

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 20th International Congress of the Transplantion Society

Year of Conference: 2005

Pages: 977-980

ISSN: 0041-1345

Publisher: Transplantation Proceedings, Elsevier


DOI: 10.1016/j.transproceed.2004.12.203

PubMed id: 15848596

Library holdings: Search Newcastle University Library for this item

ISBN: 18732623