Publications by Dr Jack Leslie - ePrints

Browsing publications by Dr Jack Leslie.

Newcastle Authors	Title	Year
Dr Jack Leslie Misti McCain Professor Helen Reeves Professor Derek Mann	Human-correlated genetic models identify precision therapy for liver cancer	2025
Rebecca Garnham Dr Daniel Geh Ryan Nelson Erik Ramon Gil Laura Wilson et al.	ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer	2024
Dr Toni Pringle Erik Ramon Gil Dr Jack Leslie Professor Fiona Oakley Professor Matthew Wright et al.	Synthesis and Preclinical Evaluation of a ⁸⁹Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury	2024
Dr Jack Leslie Dr Jill Hunter Amy Collins Amelia Rushton Lauren Russell et al.	c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis	2023
Rebecca Garnham Dr Daniel Geh Ryan Nelson Erik Ramon Gil Laura Wilson et al.	ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer	2023
Dr Sam Orange Dr Jack Leslie Professor Derek Mann	The exercise IL-6 enigma in cancer	2023
Adnan Ali Dr Caroline Wilson Dr Jack Leslie Professor Derek Mann	Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer (Nature Medicine, (2019), 25, 4, (641-655), 10.1038/s41591-019-0379-5)	2022
Dr Suzanne Madgwick Dr Saimir Luli Helene Sellier Dr Jacqueline Butterworth Dr Jack Leslie et al.	Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	2022
Dr Jack Leslie Erik Ramon Gil Kathryn Gilroy Dr Saimir Luli Maja Laszczewska et al.	CXCR2 inhibition enables NASH-HCC immunotherapy	2022
Dr Daniel Geh Dr Jack Leslie Professor Helen Reeves Professor Derek Mann	Neutrophils as potential therapeutic targets in hepatocellular carcinoma	2022
Dr Marco Zaki Dr Sari Alhasan Dr Ruchi Shukla Misti McCain Maja Laszczewska et al.	Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?	2022
Dr Jack Leslie Dr Hannah Paish Amy Collins Rebecca Scott Abi Watson et al.	A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis	2021
Dr Jack Leslie Dr Emma Scott Professor Quentin Anstee Professor Fiona Oakley	Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma	2021
Dr Jack Leslie Dr Marie-Helene Ruchaud Amy Collins Leena Habiballa Dr Gabi Saretzki et al.	Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner	2021
Dr Jack Leslie Stuart Robinson Professor Fiona Oakley Dr Saimir Luli	Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging	2021
Dr Jack Leslie Professor Fiona Oakley	Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression	2021
Dr Anna Smith Dr Julia Whitehall Carla Bradshaw Dr Fiona Robertson Dr Alasdair Blain et al.	Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis	2020
Dr Julie Worrell Dr Jack Leslie Dr Graham Smith Marco Zaki Dr Hannah Paish et al.	cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis	2020
Dr Jack Leslie Dr Marina Garcia Macia Dr Saimir Luli Dr Julie Worrell William Reilly et al.	c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis	2020
Dr Jack Leslie Benjamin Millar Alicia Del Carpio Pons Rachel Burgoyne Joseph Frost et al.	FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis	2020
Dr Jack Leslie Professor Fiona Oakley	Loss of ELK1 has differential effects on age-dependent organ fibrosis	2020
Dr Hannah Paish Lee Reed Helen Brown Mark Bryan Dr Olivier Govaere et al.	A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices	2019
Dr Hannah Paish Lee Reed Abi Watson Dr Jack Leslie Professor Fiona Oakley et al.	Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease	2019
Dr Dumitru Sirbu Dr Saimir Luli Dr Jack Leslie Professor Fiona Oakley Professor Andrew Benniston et al.	Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice using a Highly Bright Near-Infrared BODIPY Dye	2019
Dr Caroline Wilson Dr Jack Leslie Professor Derek Mann	Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer	2019
Dr Mujdat Zeybel Dr Saimir Luli Laura Sabater Dr Timothy Hardy Professor Fiona Oakley et al.	A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A	2017
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Jack Leslie Helene Sellier et al.	A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer	2016