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Browsing publications by Professor Caroline Austin.

Newcastle AuthorsTitleYearFull text
Dr Ian Cowell
Professor Caroline Austin
Disease-associated Mutations in Topoisomerase IIβ Result in Defective NK cells2022
Professor Caroline Austin
Human topoisomerases and their roles in genome stability and organization2022
Rebecca Swan
Dr Ian Cowell
Professor Caroline Austin
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes2022
Rebecca Swan
Dr Ian Cowell
Professor Caroline Austin
A role for VCP/p97 in the processing of drug-stabilized TOP2-DNA covalent complexes2021
Professor Caroline Austin
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions2021
Professor Caroline Austin
Dr Ian Cowell
Mushtaq Khazeem
Dawn Lok
Huei Ng
et al.
TOP2B’s contributions to transcription2021
Rebecca Swan
Luke Poh
Dr Ian Cowell
Professor Caroline Austin
Small molecule inhibitors confirm ubiquitin-dependent removal of TOP2-DNA covalent complexes2020
Mushtaq Khazeem
Dr Ian Cowell
Lauren Harkin
John Casement
Professor Caroline Austin
et al.
Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta2020
Professor Caroline Austin
A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents.2019
Dr Mandeep Atwal
Rebecca Swan
Ka Lee
Dr David Lee
Professor Lyle Armstrong
et al.
Intercalating TOP2 poisons attenuate topoisomerase action at higher concentrations2019
Dr Ian Cowell
Professor Caroline Austin
Mutations in topoisomerase IIβ result in a B cell immunodeficiency2019
Dr Ian Cowell
Elise Ling
Becky Swan
Professor Caroline Austin
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison s2019
Becky Swan
Dr Zbyslaw Sondka
Dr Ian Cowell
Professor Caroline Austin
Effect of TDP2 on the level of TOP2-DNA complexes and SUMOylated TOP2-DNA complexes2018
Professor Caroline Austin
Ka Lee
Becky Swan
Mushtaq Khazeem
Catriona Manville
et al.
TOP2B: The first thirty years2018
Dr Ian Cowell
Professor Caroline Austin
Topoisomerase II chromatin immunoprecipitation2018
Dr Ian Cowell
Professor Caroline Austin
Visualization and quantification of topoisomerase–DNA covalent complexes using the trapped in agarose immunostaining (TARDIS) assay2018
Dr Mandeep Atwal
Emma Lishman-Walker
Professor Caroline Austin
Dr Ian Cowell
Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy2017
Professor Caroline Austin
Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity2017
Lauren Harkin
Ayman Alzu'bi
Professor Caroline Austin
Dr Gavin Clowry
Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon2016
Ka Lee
Becky Swan
Dr Ian Cowell
Professor Graham Jackson
Professor Caroline Austin
et al.
Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II2016
Dr Ian Cowell
Professor Caroline Austin
Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule-Based Targeting of Topoisomerase II Alpha2015
Angelica Mariani
Dr Mandeep Atwal
Ka Lee
Professor Caroline Austin
Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules2015
Catriona Manville
Kayleigh Smith
Dr Zbyslaw Sondka
Holly Rance
Dr Ian Cowell
et al.
Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells2015
Professor Caroline Austin
A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation2014
Andy Best
Caroline Dalgliesh
Elaine Hong
Mahsa Kheirollahi Kouhestani
Dr Yaobo Xu
et al.
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons2014
Professor Caroline Austin
Salicylate, a Catalytic Inhibitor of Topoisomerase II, Inhibits DNA Cleavage and Is Selective for the alpha Isoform2014
Kayleigh Smith
Dr Ian Cowell
Dr Zbyslaw Sondka
Professor Caroline Austin
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI12014
Professor Caroline Austin
TopoisomeraseII beta Is Involved in Initiation of Interstrand Cross-Link Repair in Mammals2014
Professor Caroline Austin
Dr Miguel Lopez-Lazaro
Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death2013
Dr Ian Cowell
Professor Caroline Austin
Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?2012
Professor Caroline Austin
Dr Miguel Lopez-Lazaro
Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death2012
Dr Ian Cowell
Professor Caroline Austin
Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents2012
Dr Ian Cowell
Dr Zbyslaw Sondka
Kayleigh Smith
Ka Lee
Catriona Manville
et al.
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity2012
Dr Kay Padget
Hannah Curtis
Dr Ian Cowell
Dr Zbyslaw Sondka
Dr Nick Morris
et al.
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA2012
Professor Caroline Austin
Dr Miguel Lopez-Lazaro
The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I- and II-DNA Complexes in Cells2012
Pauline Heslop
Professor Caroline Austin
The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage2012
Catriona Manville
Professor Caroline Austin
Topoisomerase II alpha sites of occupancy on human chromosome 222012
Dr Ian Cowell
Dr Michael Tilby
Professor Caroline Austin
An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay2011
Dr Miguel Lopez-Lazaro
Professor Caroline Austin
Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide2011
Dr Ian Cowell
Dr Nikolaos Papageorgiou
Dr Kay Padget
Professor Caroline Austin
Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin2011
Dr Masafumi Ihara
Professor Caroline Austin
Poly(ADP-ribose) Metabolism Is Essential for Proper Nucleoprotein Exchange During Mouse Spermiogenesis2011
Professor Caroline Austin
Poly(ADP-Ribose) Polymerases PARP1 and PARP2 Modulate Topoisomerase II Beta (TOP2B) Function During Chromatin Condensation in Mouse Spermiogenesis2011
Kathryn Gilroy
Professor Caroline Austin
The Impact of the C-Terminal Domain on the Interaction of Human DNA Topoisomerase II alpha and beta with DNA2011
Dr Nicola Sunter
Dr Ian Cowell
Dr Elaine Willmore
Gary Watters
Professor Caroline Austin
et al.
Role of Topoisomerase IIbeta in DNA Damage Response following IR and Etoposide2010
Dr Miguel Lopez-Lazaro
Dr Elaine Willmore
Professor Caroline Austin
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells2010
Holly Rance
Professor Caroline Austin
The effect of quinolones on human type II topoisomerases using the Trapped in AgaRose DNA ImmunoStaining (TARDIS) assay2010
Catriona McComb
Professor Caroline Austin
Use of genotoxicity endpoints to determine the genotoxic potential of PI3-kinase inhibitors2010
Professor Caroline Austin
Dr Ian Cowell
Dr Michael Tilby
Visualisation and quantitation of DNA adducts using the Trapped in Agarose DNA immunostaining (TARDIS) assay2010
Professor Caroline Austin
Does oxidative damage contribute to the generation of leukemia?2009
Gary Watters
Professor Caroline Austin
Evaluating the gamma H2AX focus assay to assess genotoxicity2009
Gary Watters
Professor Caroline Austin
H2AX phosphorylation as a genotoxicity endpoint2009
Catriona McComb
Professor Caroline Austin
Investigations into kinase associated genotoxicity2009
Catriona McComb
Professor Caroline Austin
Kinases as therapeutic agents: a new potential genetic toxicology liability2009
Professor Caroline Austin
Model for generation of chromosomal translocations in leukaemia2009
Dr Elaine Willmore
Dr sarah Johnson
Dr Tryfonia Mainou-Fowler
Professor Graham Jackson
Dr Celine Cano
et al.
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia2008
Andrew Jobson
Dr Elaine Willmore
Dr Michael Tilby
Professor Caroline Austin
Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases2008
Dr Ian Cowell
Professor Caroline Austin
NK314, a Topoisomerase II inhibitor that specifically targets the α isoform2008
Dr Miguel Lopez-Lazaro
Dr Elaine Willmore
Dr sarah Johnson
Professor Caroline Austin
Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells2008
Dr Emma Meczes
Kathryn Gilroy
Professor Caroline Austin
The impact of the human DNA topoisomerse II C-terminal domain on activity2008
Catriona Manville
Dr Emma Clark
Dr Kay Padget
james Harvey
Dr Nick Morris
et al.
Bioinformatic analysis of topoisomerase II binding sites2007
Dr Miguel Lopez-Lazaro
Dr Elaine Willmore
Professor Caroline Austin
Cells lacking DNA topoisomerase IIβ are resistant to genistein2007
Dr Miguel Lopez-Lazaro
Dr Elaine Willmore
Andrew Jobson
Kathryn Gilroy
Hannah Curtis
et al.
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells2007
Gary Watters
Professor Caroline Austin
Is H2AX phosphorylation a biomarker for genotoxicity?2007
Dr Ian Cowell
Dr Nicola Sunter
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
Dr Michael Tilby
et al.
γH2AX foci form preferentially in euchromatin after ionising-radiation2007
Dr Miguel Lopez-Lazaro
Sami Azrak
Professor Caroline Austin
Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells2006
Kathryn Gilroy
Chrysoula Leontiou
Dr Kay Padget
Professor Jeremy Lakey
Professor Caroline Austin
et al.
mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity2006
Chrysoula Leontiou
Professor Jeremy Lakey
Professor Robert Lightowlers
Professor Caroline Austin
Mutation P732L in human DNA topoisomerase II abolishes DNA cleavage in the presence of calcium and confers drug resistance2006
Professor Caroline Austin
Nick-forming sequences may be involved in the organization of eukaryotic chromatin into ∼50 kbp loops2006
Dr Elaine Willmore
Professor Graham Jackson
Dr Tryfonia Mainou-Fowler
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
et al.
Sensitisation of B-CLL cells to chlorambucil and fludarabine via inhibition of the DNA damage sensor proteins, DNA-PK and ATM2006
Dr Miguel Lopez-Lazaro
Sami Azrak
Dr Muhammad Ayub
Professor Caroline Austin
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients2005
Lisa Smith
Dr Elaine Willmore
Professor Caroline Austin
Professor Nicola Curtin
The novel poly(ADP-ribose) polymerase inhibitor, AG14361 sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks2005
Dr Elaine Willmore
Dr Nicola Sunter
Dr Michael Tilby
Professor Graham Jackson
Professor Caroline Austin
et al.
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia2004
Fiona Errington
Dr Elaine Willmore
Chrysoula Leontiou
Dr Michael Tilby
Professor Caroline Austin
et al.
Differences in the longevity of topo IIα and topo IIβ drug-stabilized cleavable complexes and the relationship to drug sensitivity2004
Chrysoula Leontiou
Kathryn Gilroy
Gary Watters
Professor Caroline Austin
Identifying drug-resistant mutations in human topoisomerase II beta using a forced molecular evolution approach2004
Chrysoula Leontiou
Professor Jeremy Lakey
Professor Caroline Austin
Mutation E522K in human DNA topoisomerase IIβ confers resistance to methyl N-(4′-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4′-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide2004
Dr Elaine Willmore
Professor Caroline Austin
Alchemix: A novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer2003
Professor Caroline Austin
Professor Michael Taggart
Inhibitors of Actin Filament Polymerisation Attenuate Force but not Global [Ca2+]i in Isolated Pressurised Resistance Arteries2003
Chrysoula Leontiou
Professor Robert Lightowlers
Professor Jeremy Lakey
Professor Caroline Austin
Kinetic analysis of human topoisomerase IIα and β DNA binding by surface plasmon resonance2003
Professor Caroline Austin
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents2003
Professor Michael Taggart
Professor Caroline Austin
The acute effects of oestrogen receptor subtype-specific agonists on vascular contractility2003
Dr Elaine Willmore
Professor Jeremy Lakey
Professor Caroline Austin
Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIß: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability2002
Andrew Jobson
Dr Elaine Willmore
Dr Michael Tilby
Professor Caroline Austin
Characterisation of the roles of Topoisomerase I and II in the mechanism of action of novel anti-tumour agents XR11576 (MLN576) and XR5944 (MLN944)2002
Dr Elaine Willmore
Fiona Errington
Dr Michael Tilby
Professor Caroline Austin
Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells2002
Dr Elaine Willmore
Dr Michael Tilby
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
Potentiation of topoisomerase II poison cytotoxicity in the K562 human leukaemia cell line by the novel DNA-dependent protein kinase inhibitor NU70262002
Dr Emma Meczes
Professor Andrew Pearson
Professor Caroline Austin
Dr Michael Tilby
Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin2002
Dr Elaine Willmore
Professor Caroline Austin
Professor Nicola Curtin
The role of poly(ADP-ribose) polymerase-1 (PARP-1) in the cellular response to topoisomerase I poisons2002
Professor Caroline Austin
The role of topoisomerase II in the excision of DNA loop domains during apoptosis2002
Dr Kay Padget
Professor Caroline Austin
Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis2001
Dr Kay Padget
Dr Michael Tilby
Professor Caroline Austin
An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells2000
Dr Kay Padget
Professor Andrew Pearson
Dr Michael Tilby
Professor Caroline Austin
Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining)2000
Dr Trevor Jowett
Professor Caroline Austin
Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development2000
Dr Emma Meczes
Professor Caroline Austin
Mutagenesis of E477 or K505 in the B' domain of human topoisomerase IIβ increases the requirement for magnesium ions during strand passage2000
Dr Sheila Patel
Professor Caroline Austin
Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase II alpha2000
Dr Kay Padget
Professor Andrew Pearson
Professor Caroline Austin
Quantitation of DNA topoisomerase II alpha and beta in human leukaemia cells by immunoblotting2000
Dr Kay Padget
Professor Andrew Pearson
Professor Caroline Austin
Quantitation of DNA topoisomerase IIalpha and beta in human leukaemia cells by immunoblotting2000
Dr Emma Meczes
Dr Margaret Rogers
Professor Caroline Austin
Carbamate analogues of amsacrine active against non-cycling cells: Relative activity against topoisomerases IIα and β1999
Professor Caroline Austin
Cell cycle-dependent expression and subcellular localization of human barren-1 (HCAP-H).1999
Professor Caroline Austin
Human DNA topoisomerase II beta binds and cleaves four-way junction DNA in vitro1999
Professor Caroline Austin
Molecular cloning and characterization of the human topoisomerase II alpha and II beta genes: evidence for isoform evolution through gene duplication1999
Fiona Errington
Dr Elaine Willmore
Dr Michael Tilby
Professor Caroline Austin
Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: Analysis of cytotoxicity and cleavable complex formation1999
Fiona Errington
Dr Trevor Jowett
Professor Caroline Austin
sox30: a novel zebrafish sox gene expressed in a restricted manner at the midbrain-hindbrain boundary during neurogenesis1999
Dr Emma Meczes
Professor Caroline Austin
Professor Andrew Pearson
Dr Michael Tilby
Synergy studies of etoposide and cisplatin action in neuroblastoma cell lines1999
Dr Elaine Willmore
Dr Adrian Frank
Dr Kay Padget
Dr Michael Tilby
Professor Caroline Austin
et al.
Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique1998
Dr Ian Cowell
Dr Elaine Willmore
Dr David Allen Chalton
Professor Caroline Austin
Nuclear distribution of human DNA topoisomerase IIβ: A nuclear targeting signal resides in the 116-residue C-terminal tail1998
Dr Emma Meczes
Professor Caroline Austin
103 Site-directed mutagenesis of human DNA topoisomerase IIβ1997
Dr Ian Cowell
Professor Caroline Austin
cDNA library protocols1997
Dr Emma Meczes
Dr Margaret Rogers
Professor Caroline Austin
Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2β construct allows the study of topoisomerase IIβ inhibitors in yeast1997
Dr Ian Cowell
Professor Caroline Austin
Self-association of chrome domain peptides1997
Dr Ian Cowell
Professor Caroline Austin
Self-association of chromo domain peptides1997
Dr Elaine Willmore
Dr Emma Meczes
Professor Caroline Austin
Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms α and β1996
Dr Elaine Willmore
Professor Caroline Austin
Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIα (p170) and IIβ (p180)1996
Professor Caroline Austin
Dr Elaine Willmore
Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity1996
Professor Caroline Austin
Dr Elaine Willmore
Expression, domain structure and enzymatic properties of an active recombinant human DNA topoisomerase II beta1995