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Browsing publications by Professor Thomas von Zglinicki.

Newcastle AuthorsTitleYearFull text
Evon Low
Ghazaleh Alimohammadiha
Lydia Costello
Professor Thomas von Zglinicki
Dr Satomi Miwa
et al.
How good is the evidence that cellular senescence causes skin ageing?2021
Dr Jack Leslie
Dr Marie-Helene Ruchaud
Amy Collins
Leena Habiballa
Dr Gabi Saretzki
et al.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner2021
Professor Thomas von Zglinicki
Dr Tengfei Wan
Dr Satomi Miwa
Senescence in Post-Mitotic Cells: A Driver of Aging?2021
Dr Satomi Miwa
Professor Thomas von Zglinicki
Surprisingly long survival of premature conclusions about naked mole-rat biology2021
Professor Thomas von Zglinicki
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice2021
Edward Fielder
Dr Clare Tweedy
Dr Caroline Wilson
Professor Fiona Oakley
Dr Fiona LeBeau
et al.
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice2020
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Dr Gavin Richardson
Lilia Draganova
Dr Rachael Redgrave
et al.
CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians2020
Dr Antoneta Granic
Dr Carmen Martin-Ruiz
Dr Richard Dodds
Professor Dame Louise Robinson
Professor Ioakim Spyridopoulos
et al.
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study2020
Dr Carmen Martin-Ruiz
Dr Alison Yarnall
Dr John Boucher
Dr Rachael Lawson
Claire Kolenda
et al.
Senescence and inflammatory markers for predicting clinical progression in Parkinson's disease-the ICICLE-PD study2020
Dr Glyn Nelson
Professor Thomas von Zglinicki
Bioengineering the microanatomy of human skin2019
Dr Diana Jurk
Dr Joao Passos
Professor Thomas von Zglinicki
Cellular Senescence: Defining a Path Forward2019
Dr Mikolaj Ogrodnik
Patrick Kruger
Edward Fielder
Stella Victorelli
Rifqha Ruswhandi
et al.
Obesity-Induced Cellular Senescence Drives Anxiety And Impairs Neurogenesis2019
Edward Fielder
Dr Satomi Miwa
Professor Thomas von Zglinicki
Senolytics and senostatics as adjuvant tumour therapy2019
Professor Melissa Bateson
Dr Carmen Martin-Ruiz
Gillian Pepper
Professor Thomas von Zglinicki
Professor Daniel Nettle
et al.
Smoking does not accelerate leucocyte telomere attrition: A meta-analysis of 18 longitudinal cohorts2019
Edward Fielder
Julien Agneessens
Brigid Griffin
Dr Craig Parker
Dr Satomi Miwa
et al.
Sublethal whole-body irradiation causes progressive premature frailty in mice2019
Dr Mikolaj Ogrodnik
Dr Diana Jurk
Professor Thomas von Zglinicki
Targeting senescent cells alleviates obesity-induced metabolic dysfunction2019
Dr Mikolaj Ogrodnik
Dr Olena Kucheryavenko
Julien Glibert
Dr Satomi Miwa
Abbas Ishaq
et al.
The bystander effect contributes to the accumulation of senescent cells in vivo2019
Dr Olena Kucheryavenko
Dr Glyn Nelson
Professor Thomas von Zglinicki
Dr Viktor Korolchuk
Dr Bernadette Carroll
et al.
The mTORC1-autophagy pathway is a target for senescent cell elimination2019
Abbas Ishaq
Julia Schroder
Miss Edwards
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
et al.
Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissuey2018
Abbas Ishaq
Damien Dufour
Dr Kerry Cameron
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
et al.
Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue2018
Dr Glyn Nelson
Dr Olena Kucheryavenko
James Wordsworth
Professor Thomas von Zglinicki
The senescent bystander effect is caused by ROS-activated NF-κB signalling2018
Dr Diana Jurk
Professor Thomas von Zglinicki
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization2017
Dr Mikolaj Ogrodnik
Dr Satomi Miwa
Dr Dina Tiniakos
Dr Caroline Wilson
Professor Chris Day
et al.
Cellular senescence drives age-dependent hepatic steatosis2017
Dr Antoneta Granic
Dr Karen Davies
Dr Carmen Martin-Ruiz
Emerita Professor Carol Jagger
Emeritus Professor Thomas Kirkwood
et al.
Grip strength and inflammatory biomarker profiles in very old adults2017
Dr Viktor Korolchuk
Dr Satomi Miwa
Dr Bernadette Carroll
Professor Thomas von Zglinicki
Mitochondria in cell senescence: Is mitophagy the weakest link?2017
Dr Bernadette Carroll
Dr Glyn Nelson
Dr Yoana Rabanal Ruiz
Dr Olena Kucheryavenko
Professor Penny Lovat
et al.
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing2017
Dr Sabine Langie
Dr Kerry Cameron
Bartlomiej Tomaszewski
Professor Thomas von Zglinicki
Professor John Mathers
et al.
The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice2017
Edward Fielder
Professor Thomas von Zglinicki
Dr Diana Jurk
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?2017
Professor Roderick Skinner
Professor Thomas von Zglinicki
Accelerated Aging in Bone Marrow Transplant Survivors2016
Dr Satomi Miwa
Dr Achim Treumann
Amy Bell
Dr Glyn Nelson
Professor Thomas von Zglinicki
et al.
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays2016
Professor Ioakim Spyridopoulos
Dr Carmen Martin-Ruiz
Dr Catharien Hilkens
Mohammad Yadegarfar
Professor John Isaacs
et al.
CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study2016
Professor Thomas von Zglinicki
Dr Satomi Miwa
Data from molecular dynamics simulations in support of the role of human CES1 in the hydrolysis of Amplex Red2016
Dr Satomi Miwa
Dr Rafal Czapiewski
Tengfei Wan
Amy Bell
Kirsten Hill
et al.
Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria2016
Dr Carmen Martin-Ruiz
Simon Cox
Professor Thomas von Zglinicki
Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 19212016
Dr Clara Correia Melo
Francisco Marques
Rhys Anderson
Dr Graeme Hewitt
Dr Bernadette Carroll
et al.
Mitochondria are required for pro-ageing features of the senescent phenotype2016
Dr Graeme Hewitt
Dr Bernadette Carroll
Dr Clara Correia Melo
Mikolaj Ogrodnik
Dr Glyn Nelson
et al.
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair2016
Professor Bob Anderson
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Rebecca Dodds
Dr Andrew Owens
et al.
The role of cardiomyocyte senescence and regeneration in Ageing2016
Dr Antoneta Granic
Dr Terry Aspray
Professor Thomas Hill
Dr Karen Davies
Dr Joanna Collerton
et al.
25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study2015
Dr Joanna Collerton
Dr Carmen Martin-Ruiz
Emerita Professor Carol Jagger
Professor Thomas von Zglinicki
Emeritus Professor Thomas Kirkwood
et al.
Age-related frailty and its association with biological markers of ageing2015
Dr Sushma Grellscheid
Dr David Dolan
Dr Darren Daniels
Professor Thomas von Zglinicki
Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts2015
Dr Carmen Martin-Ruiz
Professor Rachel Cooper
Dr Andrew Kingston
Professor Thomas von Zglinicki
Corrigendum to "Reproducibility of Telomere Length Assessment - An International Collaborative Study" [International Journal of Epidemiology 2014, doi: 10.1093/ije/dyu191]2015
Dr Yasumichi Arai
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians2015
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements2015
Professor Thomas von Zglinicki
Live long, live well2015
Jedrzej Hoffmann
Dr Evgeniya Shmeleva
Dr Stephen Boag
Dr Karel Fiser
Dr Alan Bagnall
et al.
Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients2015
Dr Carmen Martin-Ruiz
Dr Andrew Kingston
Professor Thomas von Zglinicki
Reproducibility of telomere length assessment: an international collaborative study2015
Dr Carmen Martin-Ruiz
Dr Andrew Kingston
Professor Thomas von Zglinicki
Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic2015
Dr Antoneta Granic
Professor Thomas Hill
Emeritus Professor Thomas Kirkwood
Dr Karen Davies
Dr Joanna Collerton
et al.
Serum 25-hydroxyvitamin D and cognitive decline in the very old: The Newcastle 85+ study2015
Dr Joanna Collerton
Hannah Gautrey
Sanne van Otterdijk
Dr Karen Davies
Dr Carmen Martin-Ruiz
et al.
Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+Study2014
Dr Kirstie Anderson
Professor Mike Catt
Dr Joanna Collerton
Dr Karen Davies
Professor Thomas von Zglinicki
et al.
Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study2014
Dr Karim Bennaceur
Mark Atwill
Nayef Al Zhrany
Jedrzej Hoffmann
Professor Bernard Keavney
et al.
Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism2014
Dr Diana Jurk
Dr Caroline Wilson
Dr Joao Passos
Professor Fiona Oakley
Clara Correia Melo
et al.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice2014
Dr Piero Dalle Pezze
Dr Glyn Nelson
Gisela Otten
Dr Viktor Korolchuk
Emeritus Professor Thomas Kirkwood
et al.
Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions2014
Laura Wiley
Dr Carmen Martin-Ruiz
Emerita Professor Carol Jagger
Mohammad Yadegarfar
Professor Thomas von Zglinicki
et al.
Gender and telomere length: Systematic review and meta-analysis2014
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Professor Avan Sayer
Inflammation, telomere length, and grip strength: a 10-year longitudinal study.2014
Dr Satomi Miwa
Dr Howsun Jow
Karen Baty
Amy Bell
Dr Rafal Czapiewski
et al.
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice2014
Laura Wiley
Deepthi Ashok
Dr Carmen Martin-Ruiz
David Talbot
Dr Joanna Collerton
et al.
Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old2014
Professor Ioakim Spyridopoulos
Professor Thomas von Zglinicki
Telomere length predicts cardiovascular disease2014
Dr Antoneta Granic
Emeritus Professor Thomas Kirkwood
Dr Karen Davies
Dr Joanna Collerton
Professor Thomas Hill
et al.
25-hydroxyvitamin D and increased risk of all-cause mortality in very old women: The Newcastle 85+ study.2013
Dr John Brain
Dr Helen Robertson
Dr Aaron Ions Gardner
Dr Trevor Booth
Professor Thomas von Zglinicki
et al.
Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection2013
Dr Graeme Hewitt
Professor Thomas von Zglinicki
Dr Joao Passos
Cell sorting of young and senescent cells2013
Dr Glyn Nelson
Professor Thomas von Zglinicki
Chapter 14, Monitoring DNA Damage During Cell Senescence2013
Joanna GÓRNIAK
Dr Sabine Langie
Professor Thomas von Zglinicki
Professor Jelena Mann
Professor John Mathers
et al.
Epigenetic regulation of DNA base excision repair during ageing and dietary restriction2013
Dr Joanna Collerton
Dr Angela Pyle
Dr Gavin Hudson
Mohammad Yadegarfar
Dr Karen Davies
et al.
Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old2013
Christos Gavriilidis
Dr Satomi Miwa
Professor Thomas von Zglinicki
Professor Robert Taylor
Professor David Young
et al.
Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 22013
Dr John Boucher
Dr Gordon Duncan
Dr Alison Yarnall
Professor John O'Brien
Professor Thomas von Zglinicki
et al.
Telomere length and cognitive impairment in early Parkinson's disease2013
Joanna GÓRNIAK
Dr Kerry Cameron
Dr Kevin Waldron
Professor Thomas von Zglinicki
Professor John Mathers
et al.
Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay2013
Dr Glyn Nelson
James Wordsworth
Dr Diana Jurk
Dr Conor Lawless
Dr Carmen Martin-Ruiz
et al.
A senescent cell bystander effect: senescence-induced senescence2012
Dr Conor Lawless
Dr Diana Jurk
Dr Colin Gillespie
Dr Daryl Shanley
Dr Gabriele Saretzki
et al.
A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations2012
Professor Mark Pearce
Dr Kay Mann
Dr Carmen Martin-Ruiz
Professor Louise Parker
Professor Martin White
et al.
Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49-51 Years: The Newcastle Thousand Families Study2012
Dr Joanna Collerton
Dr Carmen Martin-Ruiz
karen Davies
Professor Mike Catt
Emerita Professor Carol Jagger
et al.
Frailty and biomarkers of inflammation, immunoscience and cellular ageing in the Newcastle 85+ Study2012
Dr Joanna Collerton
Dr Carmen Martin-Ruiz
karen Davies
Dr Catharien Hilkens
Professor John Isaacs
et al.
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study2012
Emerita Professor Carol Jagger
Professor John Bond
Professor Dame Louise Robinson
Dr Andrew Kingston
Dr Joanna Collerton
et al.
Gender differences in the association between self-rated health and mortality: Results from the Newcastle 85+ Study2012
Jedrzej Hoffmann
Dr Karel Fiser
Dr Jolanta Weaver
Ian Dimmick
Monika Loeher
et al.
High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction2012
Dr Satomi Miwa
Dr Howsun Jow
Dr Achim Treumann
Professor Thomas von Zglinicki
Low abundance of the matrix arm of complex I of mice liver mitochondria predicts longevity2012
Dr Joao Passos
Professor Thomas von Zglinicki
Mitochondrial dysfunction and cell senescence - skin deep into mammalian aging2012
Dr Diana Jurk
Chunfang Wang
Dr Satomi Miwa
Mandy Maddick
Dr Viktor Korolchuk
et al.
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response2012
Sofia Lisanti
Professor Thomas von Zglinicki
Professor John Mathers
Standardization and quality controls for the methylated DNA immunoprecipitation technique2012
Dr Diana Jurk
Professor Thomas von Zglinicki
Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver2012
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 19362012
Avgi Tsolou
Dr Glyn Nelson
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult2012
Dr Andrew Golightly
Professor Richard Boys
Professor Thomas von Zglinicki
The effect of late onset, short-term caloric restriction on the core temperature and physical activity in mice2012
Dr Irina Neganova
Dr Stuart Atkinson
Dr Joao Passos
Professor Thomas von Zglinicki
Professor Lyle Armstrong
et al.
An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells2011
Dr Carmen Martin-Ruiz
Emerita Professor Carol Jagger
Dr Andrew Kingston
Dr Joanna Collerton
Professor Mike Catt
et al.
Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study2011
Emerita Professor Carol Jagger
Dr Joanna Collerton
Dr Karen Davies
Dr Andrew Kingston
Professor Dame Louise Robinson
et al.
Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs2011
Professor Thomas von Zglinicki
Professor Christopher Hutchison
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation2011
Dr Kerry Cameron
Dr Andrew Golightly
Dr Satomi Miwa
Professor Richard Boys
Professor Thomas von Zglinicki
et al.
Gross energy metabolism in mice under late onset, short term caloric restriction2011
Dr Sabine Langie
Dr Kerry Cameron
Dr Kevin Waldron
Professor Thomas von Zglinicki
Professor John Mathers
et al.
Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a comet-based in vitro repair assay2011
Wendy den Elzen
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Emeritus Professor Thomas Kirkwood
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study2011
Mandy Maddick
Dr Satomi Miwa
Dr Diana Jurk
Dr Rafal Czapiewski
Dr Gabriele Saretzki
et al.
Adult-onset, short-term dietary restriction reduces cell senescence in mice2010
Emeritus Professor Thomas Kirkwood
Dr Carmen Martin-Ruiz
Emerita Professor Carol Jagger
Dr Joanna Collerton
Dr Andrew Kingston
et al.
Biomarkers of ageing and their relationship to disability and cognition [abstract]2010
Dr Satomi Miwa
Dr Conor Lawless
Professor Thomas von Zglinicki
Correction of radiolabel pulse-chase data by a mathematical model: application to mitochondrial turnover studies2010
Emerita Professor Carol Jagger
Dr Joanna Collerton
Professor Dame Louise Robinson
Professor Martin Eccles
Dr Andrew Kingston
et al.
Disability and dependency: How much care is in the community? [abstract]2010
Sofia Lisanti
Professor Thomas von Zglinicki
Professor John Mathers
Epigenomics: Understanding How Nutrition Modulates the Ageing Process [abstract]2010
Professor Thomas von Zglinicki
Fat tissue, aging, and cellular senescence2010
Dr Joao Passos
Dr Glyn Nelson
Dr Cedric Simillion
Dr Carole Proctor
Dr Satomi Miwa
et al.
Feedback between p21 and reactive oxygen production is necessary for cell senescence2010
Dr Conor Lawless
Dr Diana Jurk
Alina Merz
Professor Thomas von Zglinicki
Dr Joao Passos
et al.
Quantitative assessment of markers for cell senescence2010
Dr Carmen Martin-Ruiz
Dr Aurora Gomez Duran
Professor Thomas von Zglinicki
Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations2009
Dr Joao Passos
Dr Cedric Simillion
Dr Jennifer Hallinan
Professor Anil Wipat
Professor Thomas von Zglinicki
et al.
Cellular senescence: Unravelling complexity2009
Dr Glyn Nelson
Professor Thomas von Zglinicki
DNA damage foci in mitosis are devoid of 53BP12009
Chunfang Wang
Dr Diana Jurk
Mandy Maddick
Dr Glyn Nelson
Dr Carmen Martin-Ruiz
et al.
DNA damage response and cellular senescence in tissues of aging mice2009
Dr Joanna Collerton
Dr Karen Davies
Emerita Professor Carol Jagger
Dr Andrew Kingston
Professor John Bond
et al.
Health and disease in 85 year olds: Baseline findings from the Newcastle 85+ cohort study2009
Mandy Maddick
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response2009
Dr Shaheda Ahmed
Dr Joao Passos
Matthew Birket
Professor Thomas von Zglinicki
Telomerase protects mitochondria and lowers oxidative stress2009
Matthew Birket
Dr Joao Passos
Professor Thomas von Zglinicki
Professor Mark Birch-Machin
The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts2009
Dr Sharon Olijslagers
Professor Thomas von Zglinicki
Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains2009
Mandy Maddick
Professor Thomas von Zglinicki
Architectural changes in the thymus of aging mice2008
Dr Gabriele Saretzki
Theresia Walter
Dr Joao Passos
Dr Rebecca Stewart
Dr Simon Hoare
et al.
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells2008
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Dr Robin Farquharson
Endometrial telomerase shows specific expression patterns in different types of reproductive failure2008
Dr Gabriele Saretzki
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length2008
Matthew Birket
Dr Joao Passos
Professor Thomas von Zglinicki
Professor Mark Birch-Machin
Investigation of the relationship between the ageing- and photodependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts2008
Dr Joao Passos
Dr Sharon Olijslagers
Professor Thomas von Zglinicki
Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose2008
Dr Satomi Miwa
Dr Conor Lawless
Professor Thomas von Zglinicki
Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model2008
Dr Joao Passos
Professor Thomas von Zglinicki
Retrograde response, oxidative stress and cellular senescence2008
Avgi Tsolou
Dr Joao Passos
Dr Glyn Nelson
Dr Yasumichi Arai
Professor Thomas von Zglinicki
et al.
ssDNA fragments induce cell senescence by telomere uncapping2008
Dr Saeed Ahmed
Dr Joao Passos
Matthew Birket
Dr Heiko Peters
Professor Mark Birch-Machin
et al.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress2008
Dr Joao Passos
Dr Glyn Nelson
Professor Thomas von Zglinicki
Telomeres, Senescence, Oxidative stress and heterogeneity2008
Dr Joanna Collerton
Daniel Collerton
Dr Yasumichi Arai
Dr Karen Davies
Professor Martin Eccles
et al.
A comparison of computerized and pencil-and-paper tasks in assessing cognitive function in community-dwelling older people in the Newcastle 85+ pilot study2007
Professor Thomas von Zglinicki
A continuous correlation between oxidative stress and telomere shortening in fibroblasts2007
Professor Thomas von Zglinicki
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation2007
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?2007
Professor Mark Pearce
Dr Jean Adams
Dr Carmen Martin-Ruiz
Professor Martin White
Professor Thomas von Zglinicki
et al.
Growth and white blood cell telomere length at age 50: the Newcastle Thousand Families Study2007
Dr Joao Passos
Professor Thomas von Zglinicki
Methods for cell sorting of young and senescent cells2007
Dr Joao Passos
Professor Thomas von Zglinicki
Emeritus Professor Thomas Kirkwood
Mitochondria and ageing: Winning and losing in the numbers game2007
Professor Thomas von Zglinicki
Dr Joao Passos
Dr Gabriele Saretzki
Mitochondria and telomeres: Strange bedfellows in cell senescence2007
Dr Joao Passos
Dr Gabriele Saretzki
Dr Saeed Ahmed
Dr Glyn Nelson
Torsten Richter
et al.
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence2007
Dr Jean Adams
Dr Carmen Martin-Ruiz
Professor Mark Pearce
Professor Martin White
Professor Louise Parker
et al.
No association between socio-economic status and white blood cell telomere length2007
Professor Thomas von Zglinicki
Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts2007
Dr Joao Passos
Dr Glyn Nelson
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Oxygen free radicals in senescence: Are they signal transducers?2007
Dr Joao Passos
Dr Sharon Olijslagers
Dr Gabriele Saretzki
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
et al.
Premature senescence of mesothelial cells is associated with non-telomeric DNA damage2007
Dr Joanna Collerton
Dr Carmen Martin-Ruiz
Dr Antoinette Kenny
Dr Karen Davies
Professor Thomas von Zglinicki
et al.
Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study2007
Dr Joanna Collerton
Dr Karen Davies
Professor John Bond
Professor Martin Eccles
Emerita Professor Carol Jagger
et al.
The Newcastle 85+ study: Biological, clinical and psychosocial factors associated with healthy ageing: Study protocol2007
Dr Gabriele Saretzki
Dr Glyn Nelson
Dr Sharon Olijslagers
Professor Thomas von Zglinicki
TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts2007
Jill Collerton
Dr Carmen Martin-Ruiz
Dr Karen Davies
Professor Thomas von Zglinicki
Emeritus Professor Thomas Kirkwood
et al.
White blood cell telomere length is associated with left ventricular function in the oldest old: The newcastle 85+study2007
Matthew Birket
Professor Thomas von Zglinicki
Professor Mark Birch-Machin
A photoageing-associated mitochondrial DNA mutation with potential functional consequences2006
Dr Carmen Martin-Ruiz
Dr Joao Passos
Professor Thomas von Zglinicki
Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients2006
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Fat depot-specific characteristics are retained in strains derived from single human preadipocytes2006
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Mechanisms and role of oxidative damage to telomeres2006
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Mechanisms and role of oxidative damage to telomeres2006
Dr Joao Passos
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Mitochondrial dysfunction and cell senescence: Cause or consequence?2006
Jessie Jeyapalan
Dr Gabriele Saretzki
Alan Leake
Dr Michael Tilby
Professor Thomas von Zglinicki
et al.
Neuroblastoma cell apoptosis induction after cisplatin treatment is not telomere–dependent2006
Dr Joao Passos
Professor Thomas von Zglinicki
Oxygen free radicals in cell senescence: Are they signal transducers?2006
Dr Carmen Martin-Ruiz
Dr Heather Dickinson
Barbara Keys
Dr Elise Rowan
Professor Rose Anne Kenny
et al.
Telomere length predicts poststroke mortality, dementia, and cognitive decline2006
Dr Mark Boxall
Professor Tim Goodship
Dr Alison Brown
Professor Thomas von Zglinicki
Telomere shortening and haemodialysis2006
Jessie Jeyapalan
Dr Gabriele Saretzki
Alan Leake
Dr Michael Tilby
Professor Thomas von Zglinicki
et al.
Tumour-cell apoptosis after cisplatin treatment is not telomere dependent2006
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Susan Jackson
Human cell senescence as a DNA damage response2005
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: Effect of drugs and smoking2005
Dr Joao Passos
Professor Thomas von Zglinicki
Mitochondria, telomeres and cell senescence2005
Professor Lyle Armstrong
Dr Gabriele Saretzki
Dr Heiko Peters
Ilka Wappler
Dr Nicholas Hole
et al.
Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage2005
Emeritus Professor Thomas Kirkwood
Professor Thomas von Zglinicki
Science fact and the SENS agenda2005
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study2005
Professor Thomas von Zglinicki
Dr Carmen Martin-Ruiz
Telomeres as biomarkers for ageing and age-related diseases2005
Professor Thomas von Zglinicki
Dr Carmen Martin-Ruiz
Dr Gabriele Saretzki
Telomeres, cell senescence and human ageing2005
Tino Kurz
Alan Leake
Professor Thomas von Zglinicki
Lysosomal redox-active iron is important for oxidative stress-induced DNA damage2004
Tino Kurz
Alan Leake
Professor Thomas von Zglinicki
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage2004
Dr Jean Adams
Professor Martin White
Professor Mark Pearce
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
et al.
Socio-economic position, health behaviours and telomere length at age 50: a prospective cohort study2004
Dr Carmen Martin-Ruiz
Dr Gabriele Saretzki
Jessie Jeyapalan
Professor Thomas von Zglinicki
Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span2004
Dr Gabriele Saretzki
Professor Lyle Armstrong
Alan Leake
Professor Majlinda Lako
Professor Thomas von Zglinicki
et al.
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells2004
Barbara Keys
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang2004
Jessie Jeyapalan
Alan Leake
Dr Shaheda Ahmed
Dr Gabriele Saretzki
Dr Michael Tilby
et al.
The role of telomeres in etoposide induced tumor cell death2004
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Susan Jackson
A DNA damage checkpoint response in telomere-initiated senescence2003
Professor Thomas von Zglinicki
Aging at the Molecular Level2003
Jessie Jeyapalan
Dr Michael Tilby
Professor Thomas von Zglinicki
Cisplatin induced neuroblastoma cell death and the involvement of telomeres2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Extracellular superoxide dismutase is a major antioxidant and slows down telomere shortening in human fibroblasts2003
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening2003
Professor Thomas von Zglinicki
Free radical production and antioxidant defence: A primer2003
Dr Barry Davies
Islay Steele
Professor Richard Edmondson
Dr Simon Zwolinski
Dr Gabriele Saretzki
et al.
Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen2003
Tino Kurz
Alan Leake
Professor Thomas von Zglinicki
Lysosomal redox-active iron is important for oxidative stress-induced DNA damage2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress2003
Dr Mark Boxall
Barbara Keys
Professor Thomas von Zglinicki
Professor Tim Goodship
Peripheral blood mononuclear cell telomere length is unaltered in hemodialysis despite increased oxidative stress.2003
Professor Thomas von Zglinicki
Replicative senescence and the art of counting2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomerase as a promising target for human cancer gene therapy2003
Professor Thomas von Zglinicki
Emeritus Professor Thomas Kirkwood
Telomere-driven replicative senescence is a stress response [2]2003
Professor Thomas von Zglinicki
Telomeres, telomerase and the cancer cell: An introduction2003
Professor Thomas von Zglinicki
Telomeric damage in aging2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines2002
Professor Thomas von Zglinicki
Human fibroblasts in vitro senesce with a donor-specific telomere length2002
Professor Thomas von Zglinicki
Oxidative stress shortens telomeres2002
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Replicative aging, telomeres, and oxidative stress2002
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Replicative aging, telomeres, and oxidative stress2002
Professor Thomas von Zglinicki
Accelerated telomere shortening in Fanconi anemia fibroblasts - A longitudinal study2001
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection2001
Professor Thomas von Zglinicki
Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress2001
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase2001
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells2001
Professor Thomas von Zglinicki
Professor Alexander Burkle
Emeritus Professor Thomas Kirkwood
Stress, DNA damage and ageing - An integrative approach2001
Professor Thomas von Zglinicki
Telomeres and replicative senescence: Is it only length that counts?2001
Professor Thomas von Zglinicki
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts2000
Professor Thomas von Zglinicki
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes2000
Professor Thomas von Zglinicki
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts2000
Professor Thomas von Zglinicki
Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part I -Effects of proliferative senescence2000
Professor Thomas von Zglinicki
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts2000
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Regeneration der Telomeren als Basis zellulaerer Immortalitaet2000
Professor Thomas von Zglinicki
Research on ageing in Germany2000
Professor Thomas von Zglinicki
Role of oxidative stress in telomere length regulation and replicative senescence2000
Professor Thomas von Zglinicki
Role of oxidative stress in telomere length regulation and replicative senescence2000
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?2000
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomere length as a marker of oxidative stress in primary human fibroblast cultures2000
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
[Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening--an overview]1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Modification of the replicative life-span of human fibroblasts by oxidative stress1999
Professor Thomas von Zglinicki
Proteolysis and protein turnover in fibroblasts - the role of lipofuscin1999
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Ribozymes inhibiting the catalytic subunit of human telomerase (hTERT)1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomeres and human aging1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts1998