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Browsing publications by Dr Venetia Bigley.

Newcastle AuthorsTitleYearFull text
Dr Florian Gothe
Catherine Hatton
Angela Grainger
Dr Venetia Bigley
Dr Joanna Perthen
et al.
A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis2022
Professor Andrew Gennery
Dr Venetia Bigley
Dr Mary Slatter
Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study2022
Dr Venetia Bigley
PAMI Syndrome: Two Cases of an Autoinflammatory Disease with an ALPS-Like Phenotype2022
Dr Preeti Singh
Maninder Heer
Dr Anastasia Resteu
Dr Aneta Mikulasova
Dr Mojgan Reza
et al.
GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS12021
Professor Matthew Collin
Dr Venetia Bigley
Many Langerhans make light work of skin immunity2021
Dr Urszula Cytlak-Chaudhuri
Dr Anastasia Resteu
Sarah Pagan
Dr Kile Green
Dr Paul Milne
et al.
Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans2020
Dr Laura Jardine
Dr Urszula Cytlak-Chaudhuri
Dr Merry Gunawan
Dr Gary Reynolds
Dr Kile Green
et al.
Donor monocyte-derived macrophages promote human acute graft-versus-host disease2020
Dr Venetia Bigley
Professor Matthew Collin
Insights from Patients with Dendritic Cell Immunodeficiency2020
Dr Venetia Bigley
Subsets of CD1c+ DCs: Dendritic Cell Versus Monocyte Lineage2020
Dr Venetia Bigley
Professor Matthew Collin
A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space2019
Dr Venetia Bigley
Dr Urszula Cytlak-Chaudhuri
Professor Matthew Collin
Human dendritic cell immunodeficiencies2019
Dr Paul Milne
Dr Venetia Bigley
Dr Amy Publicover
Sarah Pagan
Dr Helen Marr
et al.
Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia2019
Dr Katherine Sturgess
Dr Rachel Dickinson
Professor Andrew Gennery
Professor Andrew Cant
Professor Graham Jackson
et al.
In vivo T-depleted reduced intensity transplantation for GATA2-related immune dysfunction.2018
Dr Urszula Cytlak-Chaudhuri
Dr Venetia Bigley
A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects2018
Dr Venetia Bigley
Dr Urszula Cytlak-Chaudhuri
Dr Laura Jardine
Dr Kile Green
Dr Merry Gunawan
et al.
Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation2018
Professor Matthew Collin
Dr Venetia Bigley
Human dendritic cell subsets: an update2018
Dr Urszula Cytlak-Chaudhuri
Dr Anastasia Resteu
Dr Tom Altmann
Professor Andrew Gennery
Professor Graham Jackson
et al.
Ikaros family zinc finger 1 regulates dendritic cell development and function in humans2018
Dr Urszula Cytlak-Chaudhuri
Dr Anastasia Resteu
Professor Matthew Collin
Dr Venetia Bigley
Notch signaling facilitates in vitro generation of cross-presenting classical dendritic cells2018
Dr Venetia Bigley
Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency.2018
Dr Venetia Bigley
Dr Rachel Dickinson
Professor Matthew Collin
Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells2017
Dr Venetia Bigley
Professor Matthew Collin
Professor Andrew Cant
Biallelic mutations in IRF8 impair human NK cell maturation and function2017
Dr Paul Milne
Dr Venetia Bigley
Dr Christopher Bacon
Dr Naomi McGovern
Dr Simon Bomken
et al.
Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults2017
Dr Naomi McGovern
Dr Xiao Wang
Dr Venetia Bigley
Professor Matthew Collin
Professor Muzlifah Haniffa
et al.
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-22017
Dr Kile Green
Dr Kim Pearce
Dr Laura Jardine
Dr Venetia Bigley
Professor Graham Jackson
et al.
Impact of Alemtuzumab Scheduling on Graft-versus-Host Disease after Unrelated Donor Fludarabine and Melphalan Allografts2017
Dr Paul Milne
Dr Venetia Bigley
Professor Matthew Collin
Targeted treatment of brainstem neurohistiocytosis guided by urinary cell-free DNA2017
Amit Patel
Dr Venetia Bigley
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation2017
Dr Venetia Bigley
Professor Matthew Collin
Dendritic cell analysis in primary immunodeficiency2016
Kile Green
Dr Laura Jopson
Dr Ben Barron-Millar
Barbara Innes
Sarah Pagan
et al.
Early Molecular Stratification of High-risk Primary Biliary Cholangitis2016
Professor Matthew Collin
Dr Venetia Bigley
Monocyte, macrophage, and dendritic cell development: The human perspective2016
Dr Venetia Bigley
Dr Simon Bomken
Professor Matthew Collin
National Web-Based Meetings Help to Identify Histiocytosis Patients with Refractory Disease or Sequelae who Need Individualised or Novel Treatment Strategies2016
Dr Venetia Bigley
Professor Matthew Collin
Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease2016
Professor Matthew Collin
Dr Paul Milne
Dr Venetia Bigley
Professor Muzlifah Haniffa
The Hematopoietic Origin of Adult Histiocytosis2016
Dr Sara Mannurita
Dr Venetia Bigley
Professor Matthew Collin
Dr Eleonora Gambineri
Timely follow-up of a GATA2 deficiency patient allows successful treatment2016
Dr Gary Reynolds
Dr Paul Milne
Dr Venetia Bigley
Professor Matthew Collin
Professor John Isaacs
et al.
Use of the dendritic cell marker, B and T lymphocyte attenuator, to identify functionally distinct subsets of human CD1c+ dendritic cells2016
Dr Laura Jardine
Dr Venetia Bigley
Dr Kim Pearce
Dr Alison Dickinson
Professor Graham Jackson
et al.
A comparative study of reduced dose alemtuzumab in matched unrelated donor and related donor reduced intensity transplants2015
Dr Jane Salotti
Dr Venetia Bigley
Dr Katrina Wood
Professor Matthew Collin
Dr Kevin Windebank
et al.
A Regional Study of Adults with Histiocytic Disorders in Northeast England2015
Dr Venetia Bigley
Professor Matthew Collin
Autoimmune hepatitis with T-regulatory cell deficiency in the context of GATA-2 dysfunction: A novel single gene association2015
Dr Paul Milne
Dr Venetia Bigley
Dr Merry Gunawan
Professor Muzlifah Haniffa
Professor Matthew Collin
et al.
CD1c+ blood dendritic cells have Langerhans cell potential2015
Professor Matthew Collin
Dr Venetia Bigley
Cell(s) of Origin of Langerhans Cell Histiocytosis2015
Professor Matthew Collin
Dr Rachel Dickinson
Dr Venetia Bigley
Haematopoietic and immune defects associated with GATA2 mutation2015
Professor Muzlifah Haniffa
Dr Venetia Bigley
Professor Matthew Collin
Human mononuclear phagocyte system reunited2015
Dr Venetia Bigley
Dr Naomi McGovern
Dr Paul Milne
Dr Rachel Dickinson
Sarah Pagan
et al.
Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells2015
Dr Paul Milne
Professor Matthew Collin
Dr Venetia Bigley
Dr Christopher Bacon
Dr Naomi McGovern
et al.
Mapping the BRAFV600E Hematopoietic Clone of Adult Multi-System Langerhans Cell Histiocytosis2015
Dr Mario Abinun
Professor Roderick Skinner
Dr Venetia Bigley
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases2015
Professor Matthew Collin
Dr Paul Milne
Dr Venetia Bigley
Professor Muzlifah Haniffa
Studies on the Pathway of Differentiation of LCH Cells2015
Dr Jane Salotti
Dr Venetia Bigley
Professor Matthew Collin
An Epidemiological Survey of Adults with Histiocytic Disorders in the Northeast Region of the UK2014
Dr Venetia Bigley
Professor Matthew Collin
BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups2014
Dr Paul Milne
Dr Venetia Bigley
Dr Merry Gunawan
Professor Muzlifah Haniffa
Professor Matthew Collin
et al.
CD1c+ blood dendritic cells have Langerhans cell potential2014
Dr Venetia Bigley
Professor Muzlifah Haniffa
Professor Sophie Hambleton
Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation2014
Dr Naomi McGovern
Dr Merry Gunawan
Dr Laura Jardine
Dr Elizabeth Poyner
Kile Green
et al.
Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages2014
Dr Venetia Bigley
Dr Rachel Dickinson
Dr Laura Jardine
Dr Paul Milne
Dr Helen Griffin
et al.
Human SHP-1 Mutation Causes an Autoinflammatory and Immunodeficiency Phenotype2014
Dr Naomi McGovern
Dr Merry Gunawan
Dr Laura Jardine
Dr Elizabeth Poyner
Dr Kile Green
et al.
Human tissue mononuclear phagocyte system revisited2014
Dr Rachel Dickinson
Dr Paul Milne
Sarah Pagan
Dr Venetia Bigley
Professor Matthew Collin
et al.
Reduced GATA-2 expression in individuals with DCML deficiency2014
Professor Graham Jackson
Dr Venetia Bigley
Professor Matthew Collin
T cell depleted reduced intensity transplantation is effective for patients with GATA2 mutation and severe infections or respiratory compromise2014
Dr Rachel Dickinson
Paul Milne
Dr Laura Jardine
Dr Naomi McGovern
Dr Sharon Cookson
et al.
The evolution of cellular deficiency in GATA2 mutation2014
Dr Kile Green
Dr Laura Jardine
Dr Kim Pearce
Dr Venetia Bigley
Professor Graham Jackson
et al.
Defining The Optimal Dose Of Alemtuzumab In Unrelated Donor Reduced Intensity Allografts: A UK Retrospective Study2013
Dr Naomi McGovern
Dr Kevin Windebank
Sarah Pagan
Dr Venetia Bigley
Professor Matthew Collin
et al.
Microanatomical dissection of the human dermis: The relationship between antigen presenting cells, lymphatic and blood vessels2013
Dr Laura Jardine
Ashley Ames-Draycott
Sarah Pagan
Dr Sharon Cookson
Dr Gavin Spickett
et al.
Rapid detection of dendritic cell and monocyte disorders using CD4 as a lineage marker of the human peripheral blood antigen-presenting cell compartment2013
Dr Laura Jardine
Professor Sophie Hambleton
Dr Venetia Bigley
Sarah Pagan
Dr Xiao Wang
et al.
Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands2013
Dr Eleonora Gambineri
Dr Sara Mannurita
Dr Venetia Bigley
Professor Matthew Collin
Timely Follow-up of a GATA2 Deficiency Patient as Predictor of Successful Treatment2013
Dr Kevin Windebank
Dr Venetia Bigley
Professor Muzlifah Haniffa
Professor Matthew Collin
Treatment of Adult LCH with Subcutaneous Cladribine2013
Dr Thomas Huegle
Dr Steven O'Reilly
Rachel Simpson
Dr Venetia Bigley
Professor Matthew Collin
et al.
Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts2013
Professor Matthew Collin
Dr Rachel Dickinson
Professor Muzlifah Haniffa
Dr Naomi McGovern
Dr Helen Griffin
et al.
Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation2012
Dr Venetia Bigley
Dr Rachel Dickinson
Professor Andrew Gennery
Dr Helen Griffin
Professor Muzlifah Haniffa
et al.
Human dendritic cell deficiency2012
Professor Muzlifah Haniffa
Dr Venetia Bigley
Dr Naomi McGovern
Dr Xiao Wang
Sarah Pagan
et al.
Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells2012
Professor Muzlifah Haniffa
Dr Venetia Bigley
Dr Naomi McGovern
Dr Xiao Wang
Professor Matthew Collin
et al.
Identification of a novel cross-presenting migratory dendritic cell in the human skin: the key cell for rational vaccine strategies2012
Dr Naomi McGovern
Dr Rachel Dickinson
Dr Venetia Bigley
Professor Matthew Collin
Identification of GATA-2 mutations using a simple screening procedure in patients with Papilloma virus infections2012
Professor Muzlifah Haniffa
Dr Venetia Bigley
Dr Naomi McGovern
Dr Xiao Wang
Professor Matthew Collin
et al.
Identification of the human cross-presenting migratory dendritic cell2012
Professor Muzlifah Haniffa
Dr Venetia Bigley
Dr Naomi McGovern
Professor Matthew Collin
Identification of the human cross-presenting migratory dendritic cell and harmonization of the functional classification of human and mouse dendritic cells2012
Dr Katherine Sturgess
Dr Mary Slatter
Dr Venetia Bigley
Dr Rachel Dickinson
Professor Muzlifah Haniffa
et al.
Reduced-intensity haematopoietic stem cell transplant rescues immune function and corrects pulmonary alveolar proteinosis in DCML deficiency/GATA 2 mutation2012
Dr Steven O'Reilly
Dr Venetia Bigley
Professor Matthew Collin
Dr Anja Krippner-Heidenreich
Professor Jaap van Laar
et al.
Tumor necrosis factor-alpha co-activated T-cells support a profibrotic cytokine milieu on cost of IL-10 expression in patients with systemic sclerosis2012
Professor Sophie Hambleton
Dr Venetia Bigley
Professor Muzlifah Haniffa
Dr Christopher Bacon
Professor Andrew Cant
et al.
IRF8 Mutations and Human Dendritic-Cell Immunodeficiency2011
Professor Muzlifah Haniffa
Dr Venetia Bigley
Dr Naomi McGovern
Dr Xiao Wang
Hongwei Zhou
et al.
CD141(+) human migratory dendritic cells are homologous to murine CD103+dendritic cells and excel at exogenous antigen cross-presentation2011
Dr Venetia Bigley
Professor Matthew Collin
Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome2011
Dr Venetia Bigley
Professor Muzlifah Haniffa
Dr Xiao Wang
Dr Rachel Dickinson
Dr Naomi McGovern
et al.
Dendritic cell, monocyte, B and NK lymphoid deficiency: a novel but potentially fatal haematological disorder curable with haematopoietic stem cell transplantation2011
Dr Rachel Dickinson
Dr Helen Griffin
Dr Venetia Bigley
Dr Louise Reynard
Raf Hussain
et al.
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency2011
Dr Rachel Dickinson
Dr Venetia Bigley
Dr Helen Griffin
Professor Jeremy Lakey
Dr Naomi McGovern
et al.
Human dendritic cell deficiency is caused by GATA-2 mutation2011
Professor Matthew Collin
Dr Venetia Bigley
Professor Muzlifah Haniffa
Professor Sophie Hambleton
Human dendritic cell deficiency: the missing ID?2011
Dr Naomi McGovern
Dr Venetia Bigley
Professor Muzlifah Haniffa
Dr Xiao Wang
Dr Rachel Dickinson
et al.
Human Langerin plus dendritic cells are independent of epithelial Langerhans cells; a novel perspective on Langerhans cell histiocytosis2011
Dr Katherine Sturgess
Dr Mary Slatter
Dr Venetia Bigley
Professor Muzlifah Haniffa
Dr Xiao Wang
et al.
Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation2011
Dr Venetia Bigley
Dr Xiao Wang
Dr Rachel Dickinson
Dr Naomi McGovern
Sarah Pagan
et al.
The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency2011
Dr Thomas Huegle
Dr Anja Krippner-Heidenreich
Rachel Simpson
Dr Steven O'Reilly
Dr Venetia Bigley
et al.
Tumour necrosis factor alpha receptor activated T cells of patients with systemic sclerosis are deficient in IL-10 expression but promote myofibroblast differentiation via IL-6 and TGF-beta2011
Dr Wei Cope
Dr Laura Jardine
Dr Venetia Bigley
Sarah Pagan
Brie Turner
et al.
A retrospective study of alemtuzumab level, t-cell chimerism and graft-versus-host disease using intermediate dose alemtuzumab for matched related and matched unrelated reduced-intensity transplantation2010
Dr Thomas Huegle
Dr Venetia Bigley
Professor Jaap Van Laar
Analysis of mononuclear cell subsets in dermis and blood of patients with systemic sclerosis by multicolour flow cytometry2010
Dr Venetia Bigley
Dr Laura Jardine
Professor Matthew Collin
Connecting the dots: monocyte/DC and NK subsets in human peripheral blood2010
Dr Venetia Bigley
Dr Clare Morgan
Professor Matthew Collin
Dr James Lordan
Pulmonary alveolar proteinosis due to monocytopenia: lung transplant or haematopoeitic stem cell transplant? [abstract]2010
Dr Rachel Dickinson
Dr Venetia Bigley
Professor Matthew Collin
The Equilibration of Peripheral Blood and Tissue CD3+T Cell Engraftment Is Influenced by Graft Versus Host Disease Following Reduced Intensity Conditioning Stem Cell Transplantation.2010
Professor Muzlifah Haniffa
Dr Venetia Bigley
Sarah Pagan
Dr Xiao Wang
Professor Matthew Collin
et al.
The persistence of recipient antigen presenting cells after stem cell transplantation in humans2010
Dr Venetia Bigley
Sarah Pagan
Brie Turner
Professor Graham Jackson
Professor Anne Dickinson
et al.
A Retrospective Study of Alemtuzumab Level, T Cell Chimerism and Graft Versus Host Disease Using Intermediate Dose Alemtuzumab for Matched Related and Matched Unrelated Reduced Intensity Transplantation.2009
Professor Muzlifah Haniffa
Dr Xiao Wang
Dr Venetia Bigley
Ian Dimmick
Dr Trevor Booth
et al.
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation2009
Dr Laura Jardine
Professor Sophie Hambleton
Dr Venetia Bigley
Sarah Pagan
Professor Matthew Collin
et al.
Drug-Induced, NKG2D-Dependent Sensitization of ALL Cell Lines to NK Recognition2009
Professor Matthew Collin
Dr Venetia Bigley
Professor Muzlifah Haniffa
Dr Kevin Windebank
Langerin Plus Dermal Dendritic Cells: Closer to Langerhans Cell Histiocytosis than Langerhans Cells?2009