Browse by author
Lookup NU author(s): Dr Diana Jurk, Dr Caroline WilsonORCiD, Dr Joao Passos, Professor Fiona OakleyORCiD, Clara Correia Melo, Professor Laura GreavesORCiD, Dr Gabriele Saretzki, Christopher Fox, Dr Conor LawlessORCiD, Rhys Anderson, Dr Graeme Hewitt, Nicola Fullard, Dr Glyn NelsonORCiD, Professor Jelena Mann, Professor Derek Mann, Professor Thomas von Zglinicki
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-kB induces premature ageing in mice. We also show that these mice have reduced regeneration in liver and gut. nfkb1-/- fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-kB, COX-2 and ROS, which stabilizes DNA damage. Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1-/- tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative potential. Frequencies of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts. These data indicate that systemic chronic inflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor
Author(s): Jurk D, Wilson C, Passos J, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SLF, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2014
Volume: 5
Print publication date: 24/06/2014
Online publication date: 24/06/2014
Acceptance date: 20/05/2014
Date deposited: 07/07/2014
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/ncomms5172
DOI: 10.1038/ncomms5172
Altmetrics provided by Altmetric