Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile

Ahn, M; Bevan, L; Buck, I; Cano, C; Castro, J; Cons, B; Endicott, J; Fazal, L; Ferrari, N; Hardcastle, I; Hearn, K; Holvey, R; Howard, S; Johnson, C; Jennings, C; Kucia-Tran, J; Kyle, S; Lunec, J; Lyons, J; Miller, D; Rees, D; Noble, M; Newell, DR; Reeks, J; Saini, H; St, Denis, J; Tamanini, E; Thomas, H; Thompson, N; Vinkovic, M; Ward, G; Wallis, N; Walton, H; Wedge, S; Williams, P; Willmore, E; Wilshire, N; Zhao, Y; Chessari, G

doi:10.1158/1538-7445.AM2024-6588

Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile

Lookup NU author(s): Dr Celine Cano ORCiD, Professor Jane Endicott, Dr Ian Hardcastle ORCiD, Dr Claire Jennings, Suzanne Kyle, Professor John Lunec ORCiD, Duncan Miller, Professor Martin Noble ORCiD, Huw Thomas ORCiD, Professor Steve Wedge, Dr Elaine Willmore ORCiD, Dr Yan Zhao

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Author(s): Ahn M, Bevan L, Buck I, Cano C, Castro J, Cons B, Endicott J, Fazal L, Ferrari N, Hardcastle I, Hearn K, Holvey R, Howard S, Johnson C, Jennings C, Kucia-Tran J, Kyle S, Lunec J, Lyons J, Miller D, Rees D, Noble M, Newell DR, Reeks J, Saini H, St Denis J, Tamanini E, Thomas H, Thompson N, Vinkovic M, Ward G, Wallis N, Walton H, Wedge S, Williams P, Willmore E, Wilshire N, Zhao Y, Chessari G

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: American Association for Cancer Research Annual Meeting

Year of Conference: 2024

Pages: 6588

Print publication date: 22/03/2024

Online publication date: 22/03/2024

Acceptance date: 22/03/2024

Publisher: AACR Journals

URL: https://doi.org/10.1158/1538-7445.AM2024-6588

DOI: 10.1158/1538-7445.AM2024-6588

Notes: Online ISSN: 1538-7445 Print ISSN: 0008-5472