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Browsing publications by Dr Yan Zhao.

Newcastle AuthorsTitleYearFull text
Dr Richard Noble
Huw Thomas
Dr Yan Zhao
Professor Steve Wedge
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma2022
Dr Lindi Chen
Philip Berry
Dr Jennifer Bonner
Calum Kirk
Dr Katrina Wood
et al.
Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma2019
Dr Catherine Willoughby
Huw Thomas
Dr Elaine Willmore
Suzanne Kyle
Dr Anita Wittner
et al.
Selective DNA-PKcs Inhibition Extends the Therapeutic Index of Localized Radiotherapy and Chemotherapy2019
Dr Yan Zhao
Professor John Lunec
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage2018
Honorine Lebraud
Dr Richard Noble
Nicole Phillips
Dr Yan Zhao
Professor Herbie Newell
et al.
A highly potent clickable probe for cellular imaging of MDM2 and assessing dynamic responses to MDM2-p53 inhibition2018
Alex Liu
Dr Catherine Drummond
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
An X-ray crystal structure-based understanding of the inhibition of the MDM2-p53 protein-protein interaction by isoindolinones2014
Dr Britta Vormoor
Dr Yan Zhao
Professor Herbie Newell
Evaluating the activity of the p53-MDM2 inhibitor NDD0005 in Ewing sarcoma2014
Dr Susan Tudhope
Dr Yan Zhao
Dr Anita Wittner
Annalisa Bertoli
Santosh Adhikari
et al.
Profiling inhibitors of MDM2: p53 and MDMX: p53 in relation to MDMX protein levels2014
Dr Lindi Chen
Dr Yan Zhao
Dr Gail Halliday
Philip Berry
Professor Herbie Newell
et al.
Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma2014
Annalisa Bertoli
Santosh Adhikari
Dr Suzannah Harnor
Dr Yan Zhao
Professor John Lunec
et al.
Validation studies with small-molecule modulators of the MDM2/MDMX-p53 binding interaction2014
Dr Tim Blackburn
Christopher Coxon
Dr Xiaohong Lu
Professor Bernard Golding
Professor Roger Griffin
et al.
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions2013
Michael Batey
Dr Yan Zhao
Suzanne Kyle
Professor Herbie Newell
Professor Nicola Curtin
et al.
Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer2013
Sarah Cully
Dr Celine Cano
Professor Bernard Golding
Professor Roger Griffin
Professor John Lunec
et al.
Regiospecific synthesis of isoindolinones as MDM2 inhibitors2013
Dr Joanne Martin
Michael Batey
Dr Yan Zhao
Dr Celine Cano
Dr Michele Tavecchio
et al.
Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K2012
Michael Batey
Dr Yan Zhao
Dr Helen Maitland
Professor Hing Leung
Dr Andrew Hall
et al.
Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma2011
Dr Karim Bennaceur
Dr Catherine Drummond
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones2011
Dr Yan Zhao
PKCalpha regulates platelet granule secretion and thrombus formation in mice2009
Dr Yan Zhao
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis2009
Dr Yan Zhao
A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow2008
Dr Yan Zhao
Huw Thomas
Michael Batey
Dr Ian Cowell
Professor Roger Griffin
et al.
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU74412006
Dr Yan Zhao
Dr Susan Jackson
Professor Nicola Curtin
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM2004