Publications by Dr Yan Zhao - ePrints

Browsing publications by Dr Yan Zhao.

Newcastle Authors	Title	Year
Dr Celine Cano Professor Jane Endicott Dr Ian Hardcastle Dr Claire Jennings Suzanne Kyle et al.	Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile	2024
Dr Elaine Willmore Suzanne Kyle Dr Yan Zhao Huw Thomas Dr Kenneth Rankin et al.	Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index	2024
Dr Richard Noble Huw Thomas Dr Yan Zhao Professor Steve Wedge	Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma	2022
Dr Lindi Chen Philip Berry Dr Jennifer Bonner Calum Kirk Dr Katrina Wood et al.	Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma	2019
Dr Catherine Willoughby Huw Thomas Dr Elaine Willmore Suzanne Kyle Dr Anita Wittner et al.	Selective DNA-PKcs Inhibition Extends the Therapeutic Index of Localized Radiotherapy and Chemotherapy	2019
Dr Yan Zhao Professor John Lunec	A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage	2018
Honorine Lebraud Dr Richard Noble Nicole Phillips Dr Yan Zhao Professor Herbie Newell et al.	A highly potent clickable probe for cellular imaging of MDM2 and assessing dynamic responses to MDM2-p53 inhibition	2018
Alex Liu Dr Catherine Drummond Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	An X-ray crystal structure-based understanding of the inhibition of the MDM2-p53 protein-protein interaction by isoindolinones	2014
Dr Britta Vormoor Dr Yan Zhao Professor Herbie Newell	Evaluating the activity of the p53-MDM2 inhibitor NDD0005 in Ewing sarcoma	2014
Dr Susan Tudhope Dr Yan Zhao Dr Anita Wittner Annalisa Bertoli Santosh Adhikari et al.	Profiling inhibitors of MDM2: p53 and MDMX: p53 in relation to MDMX protein levels	2014
Dr Lindi Chen Dr Yan Zhao Dr Gail Halliday Philip Berry Professor Herbie Newell et al.	Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma	2014
Annalisa Bertoli Santosh Adhikari Dr Suzannah Harnor Dr Yan Zhao Professor John Lunec et al.	Validation studies with small-molecule modulators of the MDM2/MDMX-p53 binding interaction	2014
Dr Tim Blackburn Christopher Coxon Dr Xiaohong Lu Emeritus Professor Bernard Golding Professor Roger Griffin et al.	Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions	2013
Michael Batey Dr Yan Zhao Suzanne Kyle Professor Herbie Newell Professor Nicola Curtin et al.	Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer	2013
Sarah Cully Dr Celine Cano Emeritus Professor Bernard Golding Professor Roger Griffin Professor John Lunec et al.	Regiospecific synthesis of isoindolinones as MDM2 inhibitors	2013
Dr Joanne Martin Michael Batey Dr Yan Zhao Dr Celine Cano Dr Michele Tavecchio et al.	Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K	2012
Michael Batey Dr Yan Zhao Dr Helen Maitland Professor Hing Leung Dr Andrew Hall et al.	Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma	2011
Dr Karim Bennaceur Dr Catherine Drummond Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones	2011
Dr Yan Zhao	PKCalpha regulates platelet granule secretion and thrombus formation in mice	2009
Dr Yan Zhao	The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis	2009
Dr Yan Zhao	A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow	2008
Dr Yan Zhao Huw Thomas Michael Batey Dr Ian Cowell Professor Roger Griffin et al.	Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441	2006
Dr Yan Zhao Dr Susan Jackson Professor Nicola Curtin	Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM	2004