Publications by Professor John Simpson - ePrints

Browsing publications by Professor John Simpson.

Newcastle Authors	Title	Year
Dr Ben Pippard Dr Mary Neal Dr Charlotte Holland Dr Holly Fisher Professor John Matthews et al.	Assessing Lung Ventilation and Bronchodilator Response in Asthma and Chronic Obstructive Pulmonary Disease with ¹⁹F-MRI	2024
Daniel Brooks Dr Stephen Wright Dr Nadia Mcallister Dr Sara Graziadio Dr John Davidson et al.	Assessment of the comparative agreement between chest radiographs and CT scans in intensive care units	2024
Dr Tom Hellyer Professor John Simpson	Immunomodulatory drugs in sepsis: a systematic review and meta-analysis	2024
Dr Ian Forrest Professor John Simpson	Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK	2024
Professor John Simpson	Reply: Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs	2024
Dr Jack Thompson Professor John Simpson Dr Anthony Rostron	Use of modified Berlin criteria in identifying patients with acute respiratory distress syndrome: a single-centre retrospective cohort study	2024
Dr Mary Neal Dr Charlotte Holland Dr Ben Pippard Dr Ian Forrest Dr Graham Burns et al.	¹⁹F-MRI of pulmonary ventilation: assessment of response to treatment in asthma and COPD	2023
Professor John Simpson Dr Jo Elverson Dr Vicky Ewan Dr Hilary Tedd Dr Rhys Thomas et al.	BTS clinical statement on aspiration pneumonia	2023
Dr Morag Andrew Dr Jo Elverson Dr Hilary Tedd Professor John Simpson	BTS Clinical Statement on the prevention and management of community-acquired pneumonia in people with learning disability	2023
Sarah Thompson Chong Pang Dr Tom Hellyer Dr Jonathan Scott Professor John Simpson et al.	Nitration of Chemokine CXCL8 acts as a natural mechanism to limit acute inflammation	2023
Dr Jon Murray Dr Cameron Williams Dr Clare Lendrem Amanda Winter Professor John Simpson et al.	Patient Self-Testing of Kidney Function at Home, a Prospective Clinical Feasibility Study in Kidney Transplant Recipients	2023
Zeynep Elcioglu Linda Errington Bogdan Metes Dr Wezi Sendama Jason Powell et al.	Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis	2023
Dr Nicola Hall Dr Nikki Rousseau David Hamilton Professor John Simpson Steven Powell et al.	Providing care for children with tracheostomies: a qualitative interview study with parents and health professionals	2023
Dr Kathryn Musgrave Dr Jonathan Scott Dr Wezi Sendama Aaron Gardner Fiona Dewar et al.	Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis	2023
Dr Wezi Sendama Dr Wendy Funston Dr Anthony Rostron Professor John Simpson	Tissue-Resident Memory T Cells Are Implicated in the Pathogenesis of Hypersensitivity Pneumonitis	2023
Jason Powell Steven Powell Michael Mather Lauren Beck Dr Pawel Palmowski et al.	Tracheostomy in children is associated with neutrophilic airway inflammation	2023
Dr Wendy Funston Dr Marie-Helene Ruchaud Jonathan Scott Jason Powell Dr Faye Cooles et al.	A human model of bilateral pulmonary vein sampling to assess the effects of one-lung ventilation on neutrophil function	2022
Dr Jose Luis Marin-Rubio Dr Maria Duenas Fadic Dr Tiaan Heunis Dr Abeer Dannoura Dr Joe Inns et al.	A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia	2022
Dr Charlotte Holland Dr Mary Neal Dr Ben Pippard Dr Ian Forrest Dr Graham Burns et al.	Assessing pulmonary ventilation and treatment response in patients with asthma and COPD using ¹⁹F-MRI: results from the LIFT study	2022
Dr Kathryn Musgrave Dr Jonathan Scott Dr Anthony Rostron Professor John Simpson	Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (Nature Immunology, (2022), 23, 6, (927-939), 10.1038/s41590-022-01216-z)	2022
Dr Charlotte Holland Dr Mary Neal Dr Ben Pippard Dr Ian Forrest Dr Holly Fisher et al.	Comparison of ¹⁹F-MRI, CT and spirometry in a patient with airways disease	2022
Dr Ian Forrest Professor John Simpson	Correction to: "Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis." Nikhil Hirani, Alison C. MacKinnon, Lisa Nicol, et al. Eur Respir J 2021; 57: 2002559	2022
Dr Nicola Hall David Hamilton Professor John Simpson Steven Powell Dr Malcolm Brodlie et al.	Impact of COVID-19 on carers of children with tracheostomies	2022
Dr Wezi Sendama Professor John Simpson Dr Vicky Ewan	Severe hospital-acquired pneumonia	2022
Dr Anthony Rostron Jonathan Scott Professor John Simpson	Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15	2021
Professor John Simpson	Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery	2021
Catherine Hatton Dr Rachel Botting Dr Maria Duenas Fadic Dr Iram Haq Dr Bernard Verdon et al.	Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2	2021
Jonathan Scott Dr Marie-Helene Ruchaud Dr Kate Musgrave Dr Stephen Wright Dr John Perry et al.	Phosphoinositide 3-kinase δ inhibition improves neutrophil bacterial killing in critically ill patients at high risk of infection	2021
Dr Ben Pippard Dr Mary Neal Dr Kieren Hollingsworth Dr Holly Fisher Professor John Matthews et al.	Reproducibility of ¹⁹F-MR ventilation imaging in healthy volunteers	2021
Dr Ian Forrest Professor John Simpson	Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis	2021
Professor John Simpson	Understanding the burden of interstitial lung disease post-COVID-19: The UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)	2021
Dr Tom Hellyer Dr Stephen Wright Dr Simon Baudouin Dr Anthony Rostron Jonathan Scott et al.	Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation	2020
Dr Marie-Helene Ruchaud Jonathan Scott Professor John Simpson	C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling	2020
Professor John Simpson	Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury	2020
Dr Will Jones Stephen Rice Dr Michael Power Dr Gregory Maniatopoulos Dr Jana Suklan et al.	Cost consequences for the NHS of using a two-step testing method for the detection of Clostridium difficile with a point of care, polymerase chain reaction test as the first step	2020
Dr Tom Hellyer Professor John Simpson	Could host response guide VAP treatment? No answer yet – Authors' reply	2020
Dr Elspeth Hulse Professor John Simpson	Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model	2020
Dr Joy Allen Dr Andrea Gonzalez-Ciscar Dr Clare Lendrem Dr Jana Suklan Dr Louise Johnston et al.	Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus	2020
Dr Laura Jardine Dr Urszula Cytlak-Chaudhuri Dr Merry Gunawan Dr Gary Reynolds Dr Kile Green et al.	Donor monocyte-derived macrophages promote human acute graft-versus-host disease	2020
Dr Mary Neal Dr Ben Pippard Professor John Simpson Professor Peter Thelwall	Dynamic susceptibility contrast 19F-MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging	2020
Dr Sara Graziadio Amanda Winter Dr Clare Lendrem Dr Jana Suklan Dr Will Jones et al.	How to Ease the Pain of Taking a Diagnostic Point of Care Test to the Market: A Framework for Evidence Development.	2020
Daniel Brooks Dr Sarah Wiscombe Professor John Simpson Dr Anthony Rostron	Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation	2020
Dr Tom Hellyer Professor John Simpson	Pulmonary Aspergillosis in Patients with Suspected Ventilator-associated Pneumonia in UK ICUs	2020
Dr Aaron Ions Gardner Dr Iram Haq Professor John Simpson Dr Vinciane Saint-Criq Dr Bernard Verdon et al.	Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis	2020
Dr Jim Macfarlane Dr Marie-Helene Ruchaud Jonathan Scott Professor John Simpson	Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury	2020
Dr Kathryn Musgrave Jonathan Scott Dr Wezi Sendama Dr Patrick Kesteven Dr Marie-Helene Ruchaud et al.	The differential surface expression of tissue factor between monocyte subsets	2020
Eoin Moloney Dr Joy Allen Dr Peter Carey Dr Louise Johnston Rachel O'Leary et al.	Efficiency and Health Economic Evaluations of BD OneFlow™ Flow Cytometry Reagents for Diagnosing Chronic Lymphoid Leukemia	2019
Jason Powell Dr Bernard Verdon Emerita Professor Janet Wilson Professor John Simpson Professor Jeffrey Pearson et al.	Establishment of an immortalized human subglottic epithelial cell line	2019
Dr Laura Jardine Dr Sarah Wiscombe Dr Gary Reynolds Dr David McDonald Andrew Fuller et al.	Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace.	2019
Dr Mary Neal Dr Ben Pippard Dr Kieren Hollingsworth Dr Prosenjit Dutta Professor John Simpson et al.	Optimized and accelerated ¹⁹F-MRI of inhaled perfluoropropane to assess regional pulmonary ventilation	2019
Dr Mary Neal Dr Ben Pippard Professor John Simpson Professor Peter Thelwall	Optimized and accelerated ¹⁹F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation	2019
Dr Prosenjit Dutta Dr Wendy Funston Helen Mossop Vicky Ryan Rhys Jones et al.	Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis	2019
Dr Venetia Bigley Dr Urszula Cytlak-Chaudhuri Dr Laura Jardine Dr Kile Green Dr Merry Gunawan et al.	Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation	2018
Dr Sara Graziadio Rachel O'Leary Dr Deborah Stocken Dr Joy Allen Professor John Simpson et al.	Can mid-regional pro-adrenomedullin (MR-proADM) increase the prognostic accuracy of NEWS in predicting deterioration in patients admitted to hospital with mild to moderately severe illness? A prospective single-centre observational study	2018
Dr Gill Hulme Ian Dimmick Dr Andrea Rossi Professor John Simpson	Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study	2018
Dr Louise Johnston Dr Michael Power Professor Philip Sloan Anna Long Dr Angela Silmon et al.	Clinical performance evaluation of the Idylla NRAS-BRAF mutation test on retrospectively collected formalin-fixed paraffin-embedded colorectal cancer tissue	2018
Dr Joy Allen Rachel O'Leary Dr Sara Graziadio Dr William Jones Professor John Simpson et al.	Cost implications for the NHS of using the Alere™ i Influenza A & B near patient test with nasal swabs	2018
Dr Joy Allen Rebecca O'Leary Dr Michael Power Professor John Simpson Professor Luke Vale et al.	Diagnostic accuracy and cost analysis of the Alere™ i Influenza A&B near-patient test using throat swabs	2018
Dr John Wright Dr Gill Hulme Professor John Simpson	Early PREdiction of Sepsis using leukocyte surfacebiomarkers: The ExPRES-Sepsis cohort study	2018
Jason Powell Dr James Garnett Dr Michael Mather Dr Faye Cooles Dr Bernard Verdon et al.	Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients	2018
Dr John Widdrington Dr Aurora Gomez Duran Dr Angela Pyle Dr Marie-Helene Ruchaud Jonathan Scott et al.	Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses	2018
Dr Carlos Echevarria Dr Tom Hartley Dr John Steer Professor John Simpson Emeritus Professor John Gibson et al.	Home treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluation	2018
Dr Sara Graziadio Professor John Simpson Dr Joy Allen	Interactive visualisation for interpreting diagnostic test accuracy study results	2018
Dr Vicky Ewan Dr William Reid Dr Mark Shirley Professor John Simpson Professor Stephen Rushton et al.	Oropharyngeal microbiota in frail older patients unaffected by time in hospital	2018
Dr Emma Pinder Dr Anthony Rostron Dr Tom Hellyer Dr Marie-Helene Ruchaud Jonathan Scott et al.	Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis	2018
Professor John Simpson Dr Jeffry Hogg Michael Clarke	The Red Eye and Systemic Infection	2018
Dr Tom Hellyer Professor John Simpson	16S pan-bacterial PCR can accurately identify patients with ventilator-associated pneumonia	2017
Dr Ben Pippard Dr Mary Neal Dr Prosenjit Dutta Professor John Simpson Professor Peter Thelwall et al.	19F-MRI of inhaled perfluoropropane gas: a novel approach to ventilation imaging	2017
Jonathan Scott Professor John Simpson	Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS	2017
Dr Mary Neal Dr Prosenjit Dutta Professor John Simpson Professor Andrew Blamire Professor Peter Thelwall et al.	Determination of RF and acquisition properties for optimal scan performance in 19F-MRI of inhaled perfluoropropane	2017
Dr Vicky Ewan Professor John Simpson	Hospital-acquired pneumonia surveillance - an unmet need	2017
Dr Mary Neal Dr Ben Pippard Dr Kieren Hollingsworth Professor John Simpson Professor Andrew Blamire et al.	Maximising Performance of 19F MRI of Inhaled Perfluoropropane	2017
Dr John Widdrington Dr Aurora Gomez Duran Dr Jannetta Steyn Dr Angela Pyle Dr Marie-Helene Ruchaud et al.	Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ	2017
Professor Anthony De Soyza Jonathan Scott Professor John Simpson	The heterogeneity of systemic inflammation in bronchiectasis	2017
Dr Carlos Echevarria Professor John Simpson Emeritus Professor John Gibson Professor Stephen Bourke	The PEARL score predicts 90-day readmission or death after hospitalisation for acute exacerbation of COPD	2017
Professor John Simpson Dr Gill Hulme Dr Sharon Cookson Ian Dimmick	Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers	2016
Dr Tom Hellyer Jennie Parker Professor John Simpson	Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic Use (VAPrapid-2): study protocol for a randomised controlled trial	2016
Jonathan Scott Dr Jim Macfarlane Dr Tom Hellyer Dr Anthony Rostron Dr Marie-Helene Ruchaud et al.	Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by beta(2)-agonists, corticosteroids, and critical illness	2016
Dr Carlos Echevarria Dr Colin Muirhead Dr John Steer Professor John Simpson Dr Grant Gibson et al.	Hot decaf: a rct comparing home treatment and inpatient care in copd exacerbations selected by low risk decaf score	2016
Dr Kate Musgrave Professor John Simpson Dr Patrick Kesteven	Is there any clinical or biological difference that distinguishes recurrence from non-recurrence after idiopathic PE?	2016
Dr Tom Hellyer Professor John Simpson	Low-pathogenicity Mycoplasma spp. alter human monocyte and macrophage function and are highly prevalent among patients with ventilator-acquired pneumonia	2016
Lorelle Dismore Dr Carlos Echevarria Professor John Simpson Dr Grant Gibson Professor Stephen Bourke et al.	Positive drivers and potential barriers to implementation of hospital at home selected by low risk decaf score	2016
Professor John Simpson Dr Gill Hulme Ian Dimmick	Predictive value of cell-surface markers in infections in critically ill patients: protocol for an observational study (ImmuNe FailurE in Critical Therapy (INFECT) Study)	2016
Dr Emma Pinder Dr Anthony Rostron Gladys - Dr Marie-Helene Ruchaud Jonathan Scott et al.	Randomised Controlled Trial Of Granulocyte Macrophage Colony Stimulating Factor In Critically Ill Patients With Impaired Neutrophil Function	2016
Dr Tom Hellyer Dr Vicky Ewan Peter Wilson Professor John Simpson	The Intensive Care Society recommended bundle of interventions for the prevention of ventilator-associated pneumonia	2016
Professor John Simpson	Toll- Like Receptor 3 (TLR3) L412F Single Nucleotide Polymorphism as a Causative Factor in Disease Progression in Idiopathic Pulmonary Fibrosis (IPF) During Bacterial Infection in TLR3-defective patients	2016
Dr Kate Musgrave Professor John Simpson	Use of age adjusted d-dimer monitoring to assist the withdrawal of anticoagulation following unprovoked pulmonary embolism	2016
Dr Carlos Echevarria Dr John Steer Dr Chris Stenton Dr Ian Steen Professor John Simpson et al.	Validation of the DECAF score to predict hospital mortality in acute exacerbations of COPD	2016
Dr Alice Wort Professor John Simpson Dr David Spencer Dr Matthew Thomas Dr Malcolm Brodlie et al.	Viruses associated with community-acquired pneumonia in children – a large prospective study in the post-prevenar 13 era	2016
Dr Tom Hellyer Dr Simon Baudouin Dr Stephen Wright Melinda Jeffels Dr Marie-Helene Ruchaud et al.	Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia	2015
Professor John Simpson	Sleep-disordered breathing and idiopathic pulmonary fibrosis - is there an association?	2015
Anna Irvin Kasim Jiwa Dr Sonya Carnell Professor John Simpson Professor Anthony De Soyza et al.	Sputum Neutrophils but not Interleukin-8 (IL-8) or Interleukin 17 (IL-17) Correlate with the Bronchiectasis Severity Index (BSI)	2015
Dr Carlos Echevarria Dr John Steer Dr Chris Stenton Dr Ian Steen Professor John Simpson et al.	The PEARL score predicts 90 day readmission or death following hospitalisation for an exacerbation of COPD	2015
Dr Jim Macfarlane Jonathan Scott Dr Marie-Helene Ruchaud Dr Anjam Khan Professor John Simpson et al.	Src/bcr-abl Inhibition with Dasatinib in Sterile and Non-Sterile Acute Lung Inflammation	2014
Dr Emma Browne Dr Tom Hellyer Dr Simon Baudouin Professor John Simpson	A national survey of the diagnosis and management of suspected ventilator-associated pneumonia	2014
Professor John Simpson	Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo	2014
Rhys Jones Amaran Krishnan Professor Jeffrey Pearson Professor John Simpson Professor Michael Griffin et al.	Characterisation of Reflux and Aspiration in Idiopathic Pulmonary Fibrosis; An Integrated Approach	2014
Professor John Simpson	Differential response to bacteria, and tollip expression, in the human respiratory tract	2014
Professor John Simpson	Functional characterisation of human pulmonary monocyte-like cells in lipopolysaccharide-mediated acute lung inflammation	2014
Professor John Simpson	Innate immune responses after resection for lung cancer via video-assisted thoracoscopic surgery and thoracotomy	2014
Professor John Simpson	Leukoreduced blood transfusion does not increase circulating soluble markers of inflammation: a randomized controlled trial	2014
Dr Marie-Helene Ruchaud Jonathan Scott Professor John Simpson	MPLA inhibits release of cytotoxic mediators from human neutrophils while preserving efficient bacterial killing	2014
Professor John Simpson	Reply: The Alveolar Macrophage and Acute Respiratory Distress Syndrome: A Silent Actor?	2014
Professor John Simpson	Respiratory Complications of Organophosphorus Nerve Agent and Insecticide Poisoning Implications for Respiratory and Critical Care	2014
Professor John Simpson	Serial characterisation of monocyte and neutrophil function after lung resection	2014
Professor John Simpson	Thrombolysis for acute submassive pulmonary embolism: CON viewpoint	2014
Professor John Simpson	A Randomized Controlled Trial of Peripheral Blood Mononuclear Cell Depletion in Experimental Human Lung Inflammation	2013
Dr Tom Hellyer Professor John Simpson	Antibiotic Prophylaxis for Ventilator-Associated Pneumonia More Is Less or Less Is More?	2013
Dr Catherine Popplewell Dr Marie-Helene Ruchaud Jonathan Scott Professor John Simpson	Carboplatin and Gemcitabine Impair Neutrophil Phagocytic Function	2013
Professor John Simpson	Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients	2013
Professor John Simpson	Comment on "Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans"	2013
Dr Marie-Helene Ruchaud Dr Katy Hester Dr Jim Macfarlane Professor John Simpson Professor Anthony De Soyza et al.	Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis	2013
Professor John Simpson	Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury	2013
Dr Jim Macfarlane Dr Marie-Helene Ruchaud Jonathan Scott Dr David Bulmer Dr Anjam Khan et al.	Src Kinase Inhibition Attenuates Neutrophil Degranulation Without Impairing Bacterial Killing: A Possible Therapeutic Strategy for Acute Lung Injury?	2013
Dr Tamir Ali Dr Sylvia Worthy Professor John Simpson	Statin use and cigarette smoking are associated with lower incidence of radiation pneumonitis	2013
Professor John Simpson	The Toll-like Receptor 3 L412F Polymorphism and Disease Progression in Idiopathic Pulmonary Fibrosis	2013
Professor John Simpson	Ventilator associated pneumonia: can we ensure that a quality indicator does not become a game of chance?	2013
Professor John Simpson	A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation	2012
Professor John Simpson	Bronchoalveolar Lavage does not affect the Acute Inflammatory Response Following Bronchoscopy and Mediastinoscopy	2012
Professor John Simpson	In Vivo Mononuclear Cell Tracking Using Superparamagnetic Particles of Iron Oxide Feasibility and Safety in Humans	2012
Professor John Simpson	Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury	2012
Professor John Simpson	Proteolytic Cleavage of Elafin by 20S Proteasome May Contribute to Inflammation in Acute Lung Injury	2012
Professor John Simpson	Pulmonary and systemic effects of mononuclear leukapheresis	2012
Professor John Simpson	Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3	2012
Professor John Simpson	Ventilator-Associated Pneumonia Is Characterized by Excessive Release of Neutrophil Proteases in the Lung	2012
Professor John Simpson	A randomised controlled trial of nebulised gentamicin in non-cystic fibrosis bronchiectasis	2011
Professor John Simpson	Acute Lung Injury	2011
Professor John Simpson	C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients	2011
Professor John Simpson	Hospital-acquired infection: from doctors to patients, with complements	2011
Professor John Simpson	Ly6C(hi) Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis	2011
Professor John Simpson	Multi-modal molecular imaging approaches to detect primary cells in preclinical models	2011
Dr Rebecca Hammersley Professor John Simpson	S137 The natural history of IPF in patients eligible for clinical trials vs patients not eligible	2011
Professor John Simpson	The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system	2011
Professor John Simpson	WAP domain proteins as modulators of mucosal immunity	2011
Professor John Simpson	Association of Fc_yRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression	2010
Professor John Simpson	Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia.	2010
Professor John Simpson	Fc_yreceptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis	2010
Professor John Simpson	NO-loaded Zn²⁺-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy	2010
Professor John Simpson	Panton-Valentine leukocidin (PVL) pneumonia: case report	2010
Professor John Simpson	Prognostic significance of the lung scintigraphy scan result and corresponding chest x-ray in patients with suspected pulmonary embolism	2010
Professor John Simpson	The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium	2010
Emeritus Professor John Harris Professor John Simpson	The Major Solvent in Agricultural Dimethoate Preparations is Essential for Toxicity in Minipigs [abstract]	2010
Professor John Simpson	C5a mediates peripheral blood neutrophil dysfunction in critically ill patients	2009
Professor John Simpson	Clinically suspected acute pulmonary embolism: a comparison of presentation, radiological features and outcome in patients with and without PE	2009
Professor John Simpson	Evaluation of the effect of diagnostic methodology on the reported incidence of ventilator-associated pneumonia	2009
Professor John Simpson	Idiopathic venous thromboembolic disease is associated with a poorer prognosis from subsequent malignancy	2009
Professor John Simpson	Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus.	2009
Professor John Simpson	Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not pro-inflammatory to phagocytosing macrophages	2009
Professor John Simpson	The influence of meteorological variables on the development of deep vein thrombosis	2009
Professor John Simpson	Trappin-2 promotes early clearance of pseudomonas aeruginosa through CD14-dependent macrophage activiation and neutrophil recruitment	2009
Professor John Simpson	A 29 year old man with chest pain and haemoptysis	2008
Professor John Simpson	Dunking doughnuts into cells - selective cellular translocation and in vivo analysis of polymeric micro-doughnuts	2008
Professor John Simpson	Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function	2008
Professor John Simpson	Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia	2008
Professor John Simpson	A profile of lower limb deep venous thrombosis: the hidden menace of below knee DVT	2007
Professor John Simpson	Inflammation-associated remodelling and fibrosis in the lung - a process and an end point	2007
Professor John Simpson	Endogenous pulmonary antibiotics	2006
Professor John Simpson	Towards gene therapy for inflammatory and infective pulmonary diseases	2004
Professor John Simpson	Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection	2001
Professor John Simpson	Expression of plasminogen activators and plasminogen activator inhibitors in squamous cell carcinoma of the lung is subject to marked regional variation	2001
Professor John Simpson	Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide	2001
Professor John Simpson	Current and future applications of gene therapy in respiratory disease	2000
Professor John Simpson	Emergency pre-hospital management of patients admitted with acute asthma	2000
Professor John Simpson	Pet ownership and asthma morbidity	2000
Professor John Simpson	Circulating tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) in proliferative diabetic retinopathy: a pilot study	1999
Professor John Simpson	Elafin (elastase-specific inhibitor) has antimicrobial activity against Gram positive and Gram negative respiratory pathogens	1999
Professor John Simpson	Adenovirus-mediated expression of an elastase-specific inhibitor (elafin): a comparison of different promoters	1998
Professor John Simpson	Do UK patients with complications of diabetes mellitus receive the financial State benefits to which they are entitled?	1998
Professor John Simpson	Does chronic smoking influence fibrinolytic potential in Type 1 diabetes mellitus?	1998
Professor John Simpson	Starting home nebulizer therapy: patients' expectations and subsequent outcome at two months	1998
Professor John Simpson	The management of pulmonary tuberculosis in adults notified in Scotland in 1993	1998
Professor John Simpson	The effects of smoking on the fibrinolytic potential of plasma and platelets	1997
Dr Petros Perros Professor John Simpson	Non-islet cell tumour-associated hypoglycaemia: ¹¹¹In-octreotide imaging and efficacy of octreotide, growth hormone and glucocorticosteroids	1996
Professor John Simpson	Distribution of plasminogen activator inhibitor (PAI-1) in tissues	1991
Professor John Simpson	The platelet and plasma pools of plasminogen activator inhibitor (PAI-1) vary independently in disease	1990
Professor John Simpson	Plasminogen activator inhibitor (PAI-1) in plasma and platelets	1988