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Browsing publications by Dr Ian Cowell.

Newcastle AuthorsTitleYearFull text
Dr Ian Cowell
Professor Caroline Austin
Disease-associated Mutations in Topoisomerase IIβ Result in Defective NK cells2022
Rebecca Swan
Dr Ian Cowell
Professor Caroline Austin
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes2022
Rebecca Swan
Dr Ian Cowell
Professor Caroline Austin
A role for VCP/p97 in the processing of drug-stabilized TOP2-DNA covalent complexes2021
Professor Caroline Austin
Dr Ian Cowell
Mushtaq Khazeem
Dawn Lok
Huei Ng
et al.
TOP2B’s contributions to transcription2021
Rebecca Swan
Luke Poh
Dr Ian Cowell
Professor Caroline Austin
Small molecule inhibitors confirm ubiquitin-dependent removal of TOP2-DNA covalent complexes2020
Mushtaq Khazeem
Dr Ian Cowell
Lauren Harkin
John Casement
Professor Caroline Austin
et al.
Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta2020
Dr Mandeep Atwal
Rebecca Swan
Ka Lee
Dr David Lee
Professor Lyle Armstrong
et al.
Intercalating TOP2 poisons attenuate topoisomerase action at higher concentrations2019
Dr Ian Cowell
Professor Caroline Austin
Mutations in topoisomerase IIβ result in a B cell immunodeficiency2019
Dr Ian Cowell
Elise Ling
Becky Swan
Professor Caroline Austin
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison s2019
Becky Swan
Dr Zbyslaw Sondka
Dr Ian Cowell
Professor Caroline Austin
Effect of TDP2 on the level of TOP2-DNA complexes and SUMOylated TOP2-DNA complexes2018
Professor Caroline Austin
Ka Lee
Becky Swan
Mushtaq Khazeem
Catriona Manville
et al.
TOP2B: The first thirty years2018
Dr Ian Cowell
Professor Caroline Austin
Topoisomerase II chromatin immunoprecipitation2018
Dr Ian Cowell
Professor Caroline Austin
Visualization and quantification of topoisomerase–DNA covalent complexes using the trapped in agarose immunostaining (TARDIS) assay2018
Dr Mandeep Atwal
Emma Lishman-Walker
Professor Caroline Austin
Dr Ian Cowell
Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy2017
Ka Lee
Becky Swan
Dr Ian Cowell
Professor Graham Jackson
Professor Caroline Austin
et al.
Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II2016
Dr Ian Cowell
Professor Caroline Austin
Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule-Based Targeting of Topoisomerase II Alpha2015
Catriona Manville
Kayleigh Smith
Dr Zbyslaw Sondka
Holly Rance
Dr Ian Cowell
et al.
Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells2015
Andy Best
Caroline Dalgliesh
Elaine Hong
Mahsa Kheirollahi Kouhestani
Dr Yaobo Xu
et al.
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons2014
Kayleigh Smith
Dr Ian Cowell
Dr Zbyslaw Sondka
Professor Caroline Austin
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI12014
Dr Ian Cowell
Professor Caroline Austin
Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?2012
Dr Ian Cowell
Professor Caroline Austin
Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents2012
Dr Ian Cowell
Dr Zbyslaw Sondka
Kayleigh Smith
Ka Lee
Catriona Manville
et al.
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity2012
Dr Kay Padget
Hannah Curtis
Dr Ian Cowell
Dr Zbyslaw Sondka
Dr Nick Morris
et al.
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA2012
Dr Ian Cowell
Dr Michael Tilby
Professor Caroline Austin
An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay2011
Dr Ian Cowell
Dr Nikolaos Papageorgiou
Dr Kay Padget
Professor Caroline Austin
Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin2011
Dr Nicola Sunter
Dr Ian Cowell
Dr Elaine Willmore
Gary Watters
Professor Caroline Austin
et al.
Role of Topoisomerase IIbeta in DNA Damage Response following IR and Etoposide2010
Professor Caroline Austin
Dr Ian Cowell
Dr Michael Tilby
Visualisation and quantitation of DNA adducts using the Trapped in Agarose DNA immunostaining (TARDIS) assay2010
Dr Elaine Willmore
Dr sarah Johnson
Dr Tryfonia Mainou-Fowler
Professor Graham Jackson
Dr Celine Cano
et al.
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia2008
Dr Ian Cowell
Professor Caroline Austin
NK314, a Topoisomerase II inhibitor that specifically targets the α isoform2008
Dr Ian Cowell
Dr Nicola Sunter
Professor Caroline Austin
Emeritus Professor Barbara Durkacz
Dr Michael Tilby
et al.
γH2AX foci form preferentially in euchromatin after ionising-radiation2007
Dr Yan Zhao
Huw Thomas
Michael Batey
Dr Ian Cowell
Professor Roger Griffin
et al.
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU74412006
Dr Ian Cowell
Emeritus Professor Barbara Durkacz
Dr Michael Tilby
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated2005
Dr Ian Cowell
Composite cis-acting epigenetic switches in eukaryotes: lessons from Drosophila Fab-7 for the Igf2-H19 imprinted domain2003
Dr Ian Cowell
E4BP4/NFIL3, a PAR-related bZIP factor with many roles2002
Dr Ian Cowell
Heather Morrison
Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals2002
Dr Ian Cowell
Loss of Heterochromatin Protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death2002
Dr Ian Cowell
The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure2002
Dr Ian Cowell
The gene and pseudogenes of Cbx3/mHP1 gamma2001
Dr G Wang
Dr Ian Cowell
Conservation of heterochromatin protein 1 function2000
Dr Ian Cowell
Dynamic associations of heterochromatin protein 1 with the nuclear envelope2000
Dr Ian Cowell
Mammalian chromodomain proteins: their role in genome organisation and expression2000
Dr Ian Cowell
Yeast two-hybrid library screening2000
Dr Ian Cowell
Dr Elaine Willmore
Dr David Allen Chalton
Professor Caroline Austin
Nuclear distribution of human DNA topoisomerase IIβ: A nuclear targeting signal resides in the 116-residue C-terminal tail1998
Dr Ian Cowell
Professor Caroline Austin
cDNA library protocols1997
Dr Ian Cowell
Professor Caroline Austin
Self-association of chrome domain peptides1997
Dr Ian Cowell
Professor Caroline Austin
Self-association of chromo domain peptides1997
Dr Ian Cowell
Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr11996
Dr Ian Cowell
Cloning DNA binding proteins from cDNA expression libraries using oligonucleotide binding site probes1994
Dr Ian Cowell
Repression versus activation in the control of gene transcription1994
Dr Ian Cowell
Transcriptional repression by the human bZIP factor E4BP4: Definition of a minimal repression domain1994
Dr Ian Cowell
Cloning transcription factors from a cDNA expression library1993
Dr Ian Cowell
The human mitochondrial NADH: Ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase p1-1 gene on chromosome 11q131992
Dr Ian Cowell
Transcriptional repression by a novel member of the bZIP family of transcription factors1992
Dr Ian Cowell
Glutathione transferase pi its minimal promoter and downstream cis- acting element1991
Dr Ian Cowell
Control of expression of the human glutathione S-transferase Pi gene differs from its rat homologue1989
Dr Ian Cowell
The structure of the human glutathione-Pi gene1988
Dr Ian Cowell
Characterisation of a human genomic sequence homologous to rat GSH transferase subunit 7 cDNA1987
Dr Ian Cowell
Molecular biology of the glutathione transferases1986