Publications by Professor David Thwaites - ePrints

Browsing publications by Professor David Thwaites.

Newcastle Authors	Title	Year
Dr Catriona Anderson Professor David Thwaites	Co-option of a conserved host glutamine transporter facilitates aphid/Buchnera metabolic integration	2023
Professor David Thwaites	SLC15 family of peptide transporters in GtoPdb v.2023.1	2023
Dr Catriona Anderson Professor David Thwaites	SLC36 family of proton-coupled amino acid transporters in GtoPdb v.2023.1	2023
Dr Catriona Anderson Professor David Thwaites	The Concise Guide to PHARMACOLOGY 2023/24: Transporters	2023
Dr Catriona Anderson Dr Noel Edwards Andrew Watson Dr Mike Althaus Professor David Thwaites et al.	Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB^0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives	2022
Professor David Thwaites	SLC15 family of peptide transporters in GtoPdb v.2021.3	2021
Dr Catriona Anderson Professor David Thwaites	SLC36 family of proton-coupled amino acid transporters in GtoPdb v.2021.	2021
Dr Catriona Anderson Professor David Thwaites	THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters	2021
Dr Peter Major Dr Kacper Sendra Dr Paul Dean Dr Tom Williams Andrew Watson et al.	A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites	2019
Professor David Thwaites	SLC15 family of peptide transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database.	2019
Dr Catriona Anderson Professor David Thwaites	SLC36 family of proton-coupled amino acid transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database.	2019
Dr Catriona Anderson Professor David Thwaites	SLC6A14, a Pivotal Actor on Cancer Stage: When Function Meets Structure	2019
Dr Catriona Anderson Professor David Thwaites	THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters	2019
Dr Noel Edwards Dr Catriona Anderson Dr Mike Althaus Professor David Thwaites	Trading amino acids at the aphid–Buchnera symbiotic interface	2019
Dr Noel Edwards Dr Catriona Anderson Nichola Conlon Andrew Watson Dr Tim Cheek et al.	Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters	2018
Professor David Thwaites	The Concise Guide to PHARMACOLOGY 2017/18: Overview	2017
Dr Noel Edwards Dr Sarah Rice Dr Ann Marie Hynes Dr Shalabh Srivastava Dr Iain Moore et al.	A novel LMX1B mutation in a family with end-stage renal disease of ‘unknown cause’	2015
Dr Sarah Rice Dr Noel Edwards Dr Charlie Tomson Professor David Thwaites Professor John Sayer et al.	Clinical and Genetic Analysis of a Cohort of English Cystinuria Patients	2015
Dr Sarah Rice Dr Noel Edwards Dr Alice Hartley Professor David Thwaites Professor John Sayer et al.	Clinical and genetic analysis of patients with cystinuria in the UK	2015
Dr Ann Marie Hynes Dr Sarah Rice Professor David Thwaites Professor John Sayer	Fourteen Monogenic Genes Account for 15% of Nephrolithiasis/Nephrocalcinosis	2015
Dr Sarah Rice Dr Noel Edwards Professor John Sayer Professor David Thwaites	The Effect of a Novel rBAT Mutation on the Expression and Function of System b(o,+)	2015
Dr Sarah Rice Dr Noel Edwards Professor John Sayer Professor David Thwaites	The novel rBAT mutation Y579D and activity of the amino acid transporter System b^0,+	2015
Dr Sarah Rice Professor David Thwaites Professor John Sayer	Cystinuria revisited: presentations with calcium-containing stones demands vigilance and screening in the stone clinic	2014
Professor David Thwaites	Fishing with flies, worms and bacteria: emerging models for mammalian membrane transport and trafficking	2014
Professor David Thwaites	Go with the flow – membrane transport in the gut	2013
Nichola Conlon Dr Noel Edwards Dr Tim Cheek Professor David Thwaites	Rheogenic amino acid transport by Drosophila CG4991 of the Amino Acid Auxin Permease (AAAP) transporter family	2013
Dr Catriona Anderson Professor David Thwaites	The Concise Guide to PHARMACOLOGY 2013/14: Overview	2013
Professor David Thwaites	News from the dark side!	2012
Dr Nia Edwards Dr Catriona Anderson Kelly Gatfield Mark Jevons Professor David Thwaites et al.	Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)	2011
Professor David Thwaites Dr Catriona Anderson	The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport	2011
Dr Catriona Anderson Professor David Thwaites	Hijacking solute carriers for proton-coupled drug transport	2010
Dr Catriona Anderson Mark Jevons Nichola Conlon Professor David Thwaites	Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Coexpressed in the Small Intestine	2010
Dr Catriona Anderson Dr Alison Howard Professor David Thwaites	Taurine uptake across the human intestinal brush-border membrane is via two transporters: H⁺-coupled PAT1 (SLC36A1) and Na⁺- and Cl^--dependent TauT (SLC6A6)	2009
Professor David Thwaites Dr Catriona Anderson	Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1	2007
Professor David Thwaites Dr Catriona Anderson	H⁺-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine	2007
Dr Catriona Anderson Professor David Thwaites	Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3)	2007
Dr Emily Abbot Danielle Grenade Professor David Kennedy Kelly Gatfield Professor David Thwaites et al.	Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H⁺-coupled amino-acid transporter hPAT1	2006
Professor David Kennedy Dr Demetrio Raldua Professor David Thwaites	Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2	2005
Dr Catriona Anderson Professor David Thwaites	Indirect regulation of the intestinal H⁺-coupled amino acid transporter hPAT1 (SLC36A1)	2005
Dr Emily Abbot Professor David Thwaites	Isolation and function of the amino acid transporter PAT1 (SLC36A1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles	2005
Professor David Kennedy Kelly Gatfield Dr John Winpenny Professor David Thwaites	Substrate specificity and functional characterisation of the H⁺/amino acid transporter rat PAT2 (SLC36A2)	2005
Dr Catriona Anderson Danielle Grenade Dr Katherine Wake Professor David Kennedy Professor Frederick Campbell et al.	H⁺/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat	2004
Dr Catriona Anderson Dr Ma Mendoza-Gomez Professor David Kennedy Dr Demetrio Raldua Professor David Thwaites et al.	Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC₁ receptor in a human enterocyte-like cell line (Caco-2)	2003
Dr Catriona Anderson Dr Katherine Wake Professor David Thwaites	Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2	2003
Professor David Kennedy Dr Katherine Wake Professor David Thwaites	Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2	2003
Dr Catriona Anderson Professor David Thwaites	Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1	2003
Professor David Thwaites Professor David Kennedy Dr Demetrio Raldua Dr Catriona Anderson Dr Ma Mendoza-Gomez et al.	H⁺/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na⁺/H⁺ exchanger	2002
Professor David Kennedy Professor David Thwaites	Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na⁺/H⁺ exchange activity	2002
Professor David Kennedy Professor David Thwaites	Optimal dipeptide uptake across the apical membrane of human intestinal Caco-2 cell monolayers is dependent on functional NHE3 activity	2002
Professor David Thwaites Professor Nicholas Simmons	Expression and role of sodium, potassium, chloride cotransport (NKCC1) in mouse inner medullary collecting duct (mIMCD-K2) epithelial cells	2001
Lee McCloy Emeritus Professor Paul Taylor Professor David Thwaites	Neutral amino acid transport via system L at the basolateral membrane of human intestinal Caco-2 cell monolayers	2001
Dr Catriona Anderson Dr Demetrio Raldua Professor Nicholas Simmons Professor David Thwaites	pH-dependent forskolin modulation of beta-alanine uptake at the apical surface of Caco-2 cell monolayers	2001
Professor David Kennedy Professor David Thwaites	The selective NHE3 inhibitor S1611 modulates dipeptide transport across human intestinal (Caco-2) cell monolayers	2001
Professor David Thwaites Dr Laura Basterfield Professor Nicholas Simmons	Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers	2000
Professor David Thwaites	Chloride-dependent transport of NH₄⁺ into bee retinal glial cells	1999
Professor David Thwaites Professor Dianne Ford Dr Michael Glanville Professor Nicholas Simmons	H⁺/solute-induced intracellular acidification leads to selective activation of apical Na⁺/H⁺ exchange in human intestinal epithelial cells	1999
Professor David Thwaites	H⁺-zwitterionic amino acid symport at the brush-border membrane of human intestinal epithelial (Caco-2) cells	1999
Professor Dianne Ford Professor David Thwaites Professor Nicholas Simmons Emeritus Professor Harry Gilbert Emeritus Professor Barry Hirst et al.	Substrate upregulation of the human small intestinal peptide transporter, hPepT1	1998
Professor David Thwaites	H⁺/amino acid symport in intestinal epithelia	1997
Professor David Thwaites Professor Nicholas Simmons	Na⁺-independent lysine transport in human intestinal Caco-2 cells	1996
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells	1995
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	D-Cycloserine transport in human intestinal epithelial (Caco-2) cells is mediated by a H⁺-coupled amino acid transporter	1995
Professor David Thwaites Professor Nicholas Simmons	H⁺/di-tripeptide transporter (PepT1) expression in the rabbit intestine	1995
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled alpha-methylaminoisobutyric acid transport in human intestinal Caco-2 cells	1995
Professor David Thwaites	Stereoselective uptake of beta-lactam antibiotics by the intestinal peptide transporter	1995
Professor David Thwaites Professor Nicholas Simmons	The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers	1995
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled solute transport in cultured intestinal epithelia	1994
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	L-Alanine absorption in human intestinal cells driven by the proton electrochemical gradient	1994
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco-2): identification of substrates that undergo H⁺-coupled absorption	1994
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Direct assessment of dipeptide/H⁺ symport in intact human intestinal (Caco-2) epithelium: a novel method utilising continuous intracellular pH measurement	1993
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled (Na⁺-independent) proline transport in human intestinal (Caco-2) epithelial cell monolayers	1993
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics	1993
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	Na⁺-independent, H⁺-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers	1993
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Passive transepithelial absorption of thyrotropin-releasing hormone (TRH) via a paracellular route in cultured intestinal and renal epithelial cell lines	1993
Professor David Thwaites Professor Nicholas Simmons Emeritus Professor Barry Hirst	Thyrotropin-releasing hormone (TRH) uptake in intestinal brush-border membrane vesicles: comparison with proton-coupled dipeptide and Na⁺-coupled glucose transport	1993
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic	1993
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H⁺-coupled carriers at both apical and basal membranes	1993
Professor David Thwaites	The isolation and chemical characterization of a novel vasoactive intestinal peptide-related peptide from a teleost fish, the cod, Gadus morhua	1989
Professor David Thwaites	Vasoactive intestinal polypeptide and its relatives: biochemistry, distribution, and functions	1989
Professor David Thwaites	Amino acid sequence of a biologically active vasoactive intestinal peptide from the elasmobranch Scyliorhinus canicula	1988
Professor David Thwaites	A novel vasoactive intestinal peptide (VIP) from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors	1987