Publications by Professor Mike Waring - ePrints

Browsing publications by Professor Mike Waring.

Newcastle Authors	Title	Year
Matt Anderson Thomas Carton Catherine Salvini Professor Mike Waring	Micelle-Promoted Reductive Amination of DNA-Conjugated Amines for DNA-Encoded Library Synthesis	2024
Dr Hannah Stewart Dr Mathew Martin Lan Wang Dr Eilidh Mackenzie Professor Mike Waring et al.	Conformational study into alkyl-aryl ureas to inform drug discovery	2023
Dr Harriet Annabella Stanway-Gordon Jake Odger Professor Mike Waring	Development of a Micellar-Promoted Heck Reaction for the Synthesis of DNA-Encoded Libraries	2023
Catherine Salvini Benoit Darlot Jack Davison Dr Mathew Martin Dr Susan Tudhope et al.	Fragment expansion with NUDELs – poised DNA-encoded libraries	2023
Dr Jessica Graham Dr Harriet Annabella Stanway-Gordon Professor Mike Waring	Micelle-Mediated Sonogashira Coupling for DNA-Encoded Library Synthesis	2023
Dr Nahoum Anthony Charlotte Jennings Dr Mathew Martin Dr Richard Noble Nicole Phillips et al.	Targeting cytotoxic agents through EGFR-mediated covalent binding and release	2023
Melanie Uguen Gemma Davison James Hunter Dr Mathew Martin Dr Shannon Turberville et al.	Build–Couple–Transform: A paradigm for lead-like library synthesis with scaffold diversity	2022
Professor Mike Waring	Identification and optimization of a novel series of selective PIP5K inhibitors	2022
Gemma Davison Dr Mathew Martin Dr Shannon Turberville Selma Dormen Dr Richard Heath et al.	Mapping ligand interactions of bromodomains BRD4 and ATAD2 with FragLites and PepLites ─ Halogenated probes of druglike and peptide-like molecular interactions	2022
Dr Harriet Stanway-Gordon Dr Jessica Graham Professor Mike Waring	On-DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA-Encoded Chemical Libraries	2022
Duncan Miller Tristan Reuillon Dr Lauren Molyneux Dr Tim Blackburn Dr Noel Edwards et al.	Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor	2022
Isaline Castan Professor Mike Waring	Scope of on-DNA nucleophilic aromatic substitution on weakly-activated heterocyclic substrates for the synthesis of DNA-encoded libraries	2022
Islam Al-Khawaldeh Dr Christine Basmadjian Dr Cinzia Bordoni Dr Suzannah Harnor Amy Heptinstall et al.	An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)	2021
Dr Cinzia Bordoni Daniel Brough Gemma Davison James Hunter Daniel Lopez Fernandez et al.	Cardiac Ion Channel Inhibition	2021
Edwige Picazo Amy Heptinstall Dr Celine Cano Emeritus Professor Bernard Golding Professor Mike Waring et al.	Cyclisations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides	2021
James Hunter Dr Harriet Stanway-Gordon Professor Mike Waring	Functional group tolerance of a micellar on-DNA Suzuki-Miyaura cross-coupling reaction for DNA-encoded library design	2021
James Hunter Matt Anderson Isaline Castan Dr Jessica Graham Catherine Salvini et al.	Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries	2021
Professor Mike Waring	Micellar Buchwald-Hartwig coupling of aryl and heteroarylamines for the synthesis of DNA-encoded libraries	2021
Melanie Uguen Professor Mike Waring	Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid	2021
Isaline Castan Dr Jessica Graham Catherine Salvini Dr Harriet Stanway-Gordon Professor Mike Waring et al.	On the design of lead-like DNA-encoded chemical libraries	2021
James Hunter Professor Mike Waring	The maturation of DNA encoded libraries: opportunities for new users	2021
Professor Mike Waring	Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors	2020
Gemma Davison Dr Mathew Martin Professor Martin Noble Professor Mike Waring	Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease	2020
James Hunter Dr Lisa Prendergast Professor Mike Waring	High fidelity Suzuki−Miyaura coupling for the synthesis of DNA encoded libraries enabled by micelle forming surfactants	2020
Daniel Wood Daniel Lopez Fernandez Leanne Knight Islam Al-Khawaldeh Dr Conghao Gai et al.	FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation	2019
Professor Mike Waring	Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor	2019
Professor Mike Waring	Route to Prolonged Residence Time at the Histamine H₁Receptor: Growing from Desloratadine to Rupatadine	2019
Professor Mike Waring	A Genetically Selected Cyclic Peptide Inhibitor of BCL6 Homodimerization	2018
Professor Mike Waring	Cancer II	2018
Professor Mike Waring	Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC to Provide Insight into Small Molecule Targeting of BCL6	2018
Professor Mike Waring	Practical application of ligand efficiency metrics in lead optimisation	2018
Emeritus Professor Bernard Golding Professor Mike Waring	The consequences of ‘Brexit’ for drug discovery and development, and the regulatory implications	2018
Professor Mike Waring	Discovery of pyrazolo[1,5-a]pyrimidine B-cell lymphoma 6 (BCL6) binders and optimization to high affinity macrocyclic inhibitors	2017
Professor Mike Waring	Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics	2017
Professor Mike Waring	Structure-affinity Relationships and Structure-kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists	2017
Professor Mike Waring	Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers	2017
Professor Mike Waring	AZD5153: a novel bivalent BET bromodomain inhibitor highly active against hematologic malignancies	2016
Professor Mike Waring	Enhanced cytocompatibility and functional group content of poly(L-lysine) dendrimers by grafting with poly(oxazolines)	2016
Professor Mike Waring	Optimisation of a series of bivalent triazolopyridazine based bromodomain and extraterminal inhibitors: the discovery of (3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)	2016
Professor Mike Waring	Potent and selective bivalent inhibitors of BET bromodomains	2016
Professor Mike Waring	Preparation of triazolopyridazine derivatives for use as antiproliferative agents	2016
Professor Mike Waring	A safe and scalable synthesis of 2-hydroxy-3-alkoxypropionates by epoxide ring opening	2015
Professor Mike Waring	An analysis of the attrition of drug candidates from four major pharmaceutical companies	2015
Professor Mike Waring Duncan Miller	Challenges in the Medicinal Chemical Optimization of Binding Kinetics	2015
Professor Mike Waring	Discovery of a series of 2-(pyridinyl)pyrimidines as potent antagonists of GPR40	2015
Professor Mike Waring	Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα)	2015
Professor Mike Waring	An Improved Method for Difluorocyclopropanation of Alkenes	2014
Professor Mike Waring	Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor	2014
Professor Mike Waring Dr James Smith	Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β- inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.	2014
Professor Mike Waring	The challenges of increasing drug discovery productivity	2014
Professor Mike Waring	A chemistry Wiki to facilitate and enhance chemical design in drug discovery	2013
Professor Mike Waring	Lipophilicity in drug discovery.	2010