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Browsing publications by Dr Mathew Martin.

Newcastle AuthorsTitleYearFull text
Duncan Miller
Tristan Reuillon
Dr Lauren Molyneux
Dr Tim Blackburn
Dr Noel Edwards
et al.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor2022
Dr Mathew Martin
Recent advances in kinase drug discovery part i: The editors’ take2021
Gemma Davison
Dr Mathew Martin
Professor Martin Noble
Professor Mike Waring
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease2020
Daniel Wood
Svitlana Korolchuk
Dr Natalie Tatum
Lan Wang
Professor Jane Endicott
et al.
Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition2019
Daniel Wood
Daniel Lopez Fernandez
Leanne Knight
Islam Al-Khawaldeh
Dr Conghao Gai
et al.
FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation2019
Stephanie Myers
Duncan Miller
Dr Lauren Molyneux
Dr Mercedeh Arasta
Dr Ruth Bawn
et al.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD42019
Duncan Miller
Dr Mathew Martin
Santosh Adhikari
Alfie Brennan
Professor Jane Endicott
et al.
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach2018
Dr Mathew Martin
Professor Martin Noble
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor2018
Dr Mathew Martin
Dr Helen Lawrence
Aurora Kinase Inhibitors and methods of making and using thereof2017
Christopher Coxon
Dr Suzannah Harnor
Dr Mathew Martin
Dr Benoit Carbain
Professor Bernard Golding
et al.
Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines2017
Dr Mathew Martin
Structural basis of Wee kinases functionality and inactivation by diverse small molecule inhibitors2017
Dr Mathew Martin
Professor Jane Endicott
Professor Martin Noble
Structure-based discovery of cyclin-dependent protein kinase inhibitors2017
Dr Mathew Martin
Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3)2016
Svitlana Korolchuk
Dr Mathew Martin
Dr Will Stanley
Professor Martin Noble
Professor Jane Endicott
et al.
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK2015
Elisa Meschini
Dr Regina Mora Vidal
Dr Mathew Martin
Dr Will Stanley
Tristan Reuillon
et al.
Identification and characterization of an irreversible inhibitor of CDK22015
Dr Mathew Martin
Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 22015
Bailey Massa
Dr Mathew Martin
Professor Martin Noble
Professor Jane Endicott
Structural and functional characterization of Skp2-containing complexes2015
Dr Mathew Martin
Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors2014
Dr Mathew Martin
Elisa Meschini
Lan Wang
Dr Regina Mora Vidal
Tristan Reuillon
et al.
Identification and characterization of an irreversible inhibitor of CDK22014