Publications by Dr Mathew Martin - ePrints

Browsing publications by Dr Mathew Martin.

Newcastle Authors	Title	Year
Dr Jessica Watt Dr Mathew Martin Professor Jane Endicott Professor Martin Noble	Different applications and differentiated libraries for crystallographic fragment screening	2025
Pasquale Morese Ayaz Ahmad Dr Mathew Martin Dr Richard Noble Sara Pintar et al.	Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding	2025
Amy George Frances Sidgwick Dr Jessica Watt Dr Mathew Martin Professor Matthias Trost et al.	Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling	2023
Dr Hannah Stewart Dr Mathew Martin Lan Wang Dr Eilidh Mackenzie Professor Mike Waring et al.	Conformational study into alkyl-aryl ureas to inform drug discovery	2023
Dr Mathew Martin Professor Jane Endicott Professor Martin Noble Dr Natalie Tatum	Crystallographic fragment screening in academic cancer drug discovery	2023
Dr Catherine Salvini Benoit Darlot Jack Davison Dr Mathew Martin Dr Susan Tudhope et al.	Fragment expansion with NUDELs – poised DNA-encoded libraries	2023
Duncan Miller Dr Suzannah Harnor Dr Mathew Martin Dr Richard Noble Professor Steve Wedge et al.	Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy	2023
Dr Nahoum Anthony Charlotte Jennings Dr Mathew Martin Dr Richard Noble Nicole Phillips et al.	Targeting cytotoxic agents through EGFR-mediated covalent binding and release	2023
Dr Jose Luis Marin-Rubio Dr Maria Duenas Fadic Dr Tiaan Heunis Dr Abeer Dannoura Dr Joe Inns et al.	A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia	2022
Melanie Uguen Gemma Davison James Hunter Dr Mathew Martin Dr Shannon Turberville et al.	Build–Couple–Transform: A paradigm for lead-like library synthesis with scaffold diversity	2022
Dr Mathew Martin Professor Martin Noble	Exiting the tunnel of uncertainty: crystal soak to validated hit	2022
Gemma Davison Dr Mathew Martin Dr Shannon Turberville Selma Dormen Dr Richard Heath et al.	Mapping ligand interactions of bromodomains BRD4 and ATAD2 with FragLites and PepLites ─ Halogenated probes of druglike and peptide-like molecular interactions	2022
Duncan Miller Tristan Reuillon Dr Lauren Molyneux Dr Tim Blackburn Dr Noel Edwards et al.	Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor	2022
Dr Mathew Martin	Recent advances in kinase drug discovery part i: The editors’ take	2021
Gemma Davison Dr Mathew Martin Professor Martin Noble Professor Mike Waring	Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease	2020
Daniel Wood Svitlana Korolchuk Dr Natalie Tatum Lan Wang Professor Jane Endicott et al.	Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition	2019
Daniel Wood Daniel Lopez Fernandez Leanne Knight Islam Al-Khawaldeh Dr Conghao Gai et al.	FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation	2019
Stephanie Myers Duncan Miller Dr Lauren Molyneux Dr Mercedeh Arasta Dr Ruth Bawn et al.	Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4	2019
Duncan Miller Dr Mathew Martin Santosh Adhikari Alfie Brennan Professor Jane Endicott et al.	Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach	2018
Dr Mathew Martin Professor Martin Noble	Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor	2018
Dr Mathew Martin Dr Helen Lawrence	Aurora Kinase Inhibitors and methods of making and using thereof	2017
Christopher Coxon Dr Suzannah Harnor Dr Mathew Martin Dr Benoit Carbain Emeritus Professor Bernard Golding et al.	Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines	2017
Dr Mathew Martin	Structural basis of Wee kinases functionality and inactivation by diverse small molecule inhibitors	2017
Dr Mathew Martin Professor Jane Endicott Professor Martin Noble	Structure-based discovery of cyclin-dependent protein kinase inhibitors	2017
Dr Mathew Martin	Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3)	2016
Svitlana Korolchuk Dr Mathew Martin Dr Will Stanley Professor Martin Noble Professor Jane Endicott et al.	CDK1 structures reveal conserved and unique features of the essential cell cycle CDK	2015
Elisa Meschini Dr Regina Mora Vidal Dr Mathew Martin Dr Will Stanley Tristan Reuillon et al.	Identification and characterization of an irreversible inhibitor of CDK2	2015
Dr Mathew Martin	Stability of the human Hsp90-p50^Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2	2015
Bailey Massa Dr Mathew Martin Professor Martin Noble Professor Jane Endicott	Structural and functional characterization of Skp2-containing complexes	2015
Dr Mathew Martin	Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors	2014
Dr Mathew Martin Elisa Meschini Lan Wang Dr Regina Mora Vidal Tristan Reuillon et al.	Identification and characterization of an irreversible inhibitor of CDK2	2014