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Browsing publications by Dr Catherine Arden.

Newcastle AuthorsTitleYearFull text
Xuefei Yu
Dr Catherine Arden
Dr Rolando Berlinguer Palmini
Dr Chun Chen
Carla Bradshaw
et al.
Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation2022
Amelia Williams
Merilin Georgiou
Dr Catherine Arden
Autophagy in the pancreas2021
Dr Francesco Zummo
Merilin Georgiou
Kirsty Cullen
Minna Honkanen-Scott
Professor James Shaw
et al.
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis2021
Tabassum Moonira
Dr Shruti Chachra
Dr Brian Ford
Ahmed Alshawi
Dr Catherine Arden
et al.
Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation2020
Dr Francesco Zummo
Dr Catherine Arden
Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells.2019
Dr Catherine Arden
A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy2018
Dr Francesco Zummo
Kirsty Cullen
Minna Honkanen-Scott
Professor James Shaw
Professor Penny Lovat
et al.
Glucagon-like peptide-1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function2017
Dr Ziad Al-Oanzi
Sofia Fountana
Tabassum Moonira
Dr Susan Tudhope
John Petrie
et al.
Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes2017
Dr Francesco Zummo
Kirsty Cullen
Professor Penny Lovat
Professor James Shaw
Dr Catherine Arden
et al.
Glucagon-like peptide-1 requires EPAC activity to restore autophagy and protect pancreatic beta cells from cell death2016
Tabassum Moonira
Dr Ziad Al-Oanzi
Dr Catherine Arden
Professor Loranne Agius
Metformin action in hepatocytes is not mimicked by selective activation of AMPactivated protein kinase2016
Dr Francesco Zummo
Kirsty Cullen
Professor Penny Lovat
Professor James Shaw
Dr Catherine Arden
et al.
An emerging role for autophagy in the regulation of beta cell survival by glucagon-like peptide-12015
Dr Francesco Zummo
Kirsty Cullen
Professor Penny Lovat
Professor James Shaw
Dr Catherine Arden
et al.
Glucagon-like peptide 1 protects pancreatic beta cells from programmed cell death: a role for autophagy2015
Kirsty Cullen
Dr Ziad Al-Oanzi
Professor Loranne Agius
Dr Catherine Arden
Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein2014
Dr Catherine Arden
Kirsty Cullen
Dr Ziad Al-Oanzi
Professor Loranne Agius
A role for glucagon in the post-translational regulation of hepatic glucokinase activity2013
Dr John Petrie
Dr Ziad Al-Oanzi
Dr Catherine Arden
Dr Susan Tudhope
Professor Jelena Mann
et al.
Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter2013
Dr Susan Tudhope
Dr Fiona Malcomson
Dr Catherine Arden
Dr Laura Hampson
Professor Loranne Agius
et al.
A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-52012
Dr Catherine Arden
Dr Susan Tudhope
Dr Ziad Al-Oanzi
Kirsty Cullen
Professor Loranne Agius
et al.
Fructose 2,6-bisphosphate is essential for glucose-regulated genetranscription of glucose-6-phosphatase and other ChREBP target genes inhepatocytes2012
Dr Ziad Al-Oanzi
Dr John Petrie
Dr Susan Tudhope
Dr Catherine Arden
Professor Loranne Agius
et al.
The insulin-independent glucose-induction of the hepatic gluconeogenic enzyme glucose 6-phosphatase involves distinct metabolic pathways and transcription factors2012
Dr Catherine Arden
Dr Susan Tudhope
Dr Ziad Al-Oanzi
Professor Loranne Agius
Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis2011
Professor Loranne Agius
Dr Catherine Arden
Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells2011
Dr Catherine Arden
Claire Marriott
Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK2010
Aiman Mahmoud
Dr Catherine Arden
Dr Audrey Brown
Dr Susan Campbell
Dr Ali Aldibbiat
et al.
Muscle targeted gene therapy for diabetes mellitus: role of proteasomal decay in mutant proinsulin plasmid efficiency2009
Dr Catherine Arden
Kirsty Cullen
Professor Loranne Agius
Visualisation of protein-protein interactions of glucokinase in living cells2009
Dr Catherine Arden
Dr Laura Hampson
Professor James Shaw
Dr Ali Aldibbiat
Dr Graham Holliman
et al.
A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells2008
Mohammed Mukhtar
Victoria Payne
Dr Catherine Arden
Dr Andrew Harbottle
Professor Loranne Agius
et al.
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase2008
Dr Catherine Arden
Dr Alison Trainer
Dr Kathleen Scougall
Professor James Shaw
Professor Loranne Agius
et al.
Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic β-cells: Evidence for cellular instability of catalytic activity2007
Victoria Payne
Dr Catherine Arden
Professor Loranne Agius
Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats2007
Dr Catherine Arden
Professor Loranne Agius
Determination of PFK-2/FBPase-2 isoforms and the role of fructose 2,6 bisphosphate in pancreatic islets and beta-cells lines2007
Dr Catherine Arden
Dr Kathleen Scougall
Professor James Shaw
Professor Loranne Agius
[abstract] Generation of MIN6 stable cell lines expressing GFP-tagged glucokinase for cellular analysis of glucokinase mutants2006
Dr Laura Hampson
Dr Catherine Arden
Professor Loranne Agius
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site2006
Dr Catherine Arden
Professor James Shaw
Professor Loranne Agius
Catalytic instability of the glucokinase MODY-2 mutants V62M and G72R in pancreatic beta cells2006
Dr Catherine Arden
Professor Loranne Agius
Glucokinase regulatory protein is associated with mitochondria in hepatocytes2006
Dr Catherine Arden
Dr Laura Hampson
Dr Susan Aiston
Dr Linda Harndahl
Professor Loranne Agius
et al.
Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats2006
Dr Susan Aiston
Dr Laura Hampson
Dr Catherine Arden
Professor Loranne Agius
The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes2006
Victoria Payne
Dr Catherine Arden
Professor Loranne Agius
Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes2005
Dr Catherine Arden
Dr Andrew Harbottle
Professor Loranne Agius
Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation2004