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An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)

Lookup NU author(s): Islam Al-Khawaldeh, Dr Christine Basmadjian, Dr Cinzia Bordoni, Dr Suzannah Harnor, Amy Heptinstall, Dr Stephen Hobson, Dr Claire Jennings, Shaimaa Khalifah, Honorine Lebraud, Duncan Miller, Dr Harry Shrives, Joao Victor de De Souza Cunha, Dr Hannah Stewart, Dr Max Temple, Dr Jane Totobenazara, Julie Tucker, Dr Susan Tudhope, Lan Wang, Dr Agnieszka Bronowska, Dr Celine Cano, Professor Jane Endicott, Professor Bernard Golding, Dr Ian Hardcastle, Professor Ian Hickson, Professor Steve Wedge, Dr Elaine Willmore, Professor Martin Noble, Professor Mike Waring

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Author(s): Al-Khawaldeh I, Aldred GG, Alyassiri M, Basmadjian C, Bordoni C, Harnor SJ, Heptinstall AB, Hobson SJ, Jennings CE, Khalifa S, Lebraud H, Miller DC, Shrives HJ, de Souza JV, Stewart HL, Temple M, Totobenazara J, Tucker JA, Tudhope SJ, Wang LZ, Bronowska AK, Cano C, Endicott JA, Golding BT, Hardcastle IR, Hickson I, Wedge SR, Willmore E, Noble MEM, Waring MJ

Publication type: Article

Publication status: Published

Journal: Journal of Medicinal Chemistry

Year: 2021

Issue: ePub ahead of Print

Online publication date: 02/07/2021

Acceptance date: 21/06/2021

Date deposited: 05/07/2021

ISSN (print): 0022-2623

ISSN (electronic): 1520-4804

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acs.jmedchem.0c01249

DOI: 10.1021/acs.jmedchem.0c01249


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