Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Martin Cooke
Professor Matt Wright
| Ionic Liquid 1-Octyl-3-Methylimidazolium (M8OI) Is Mono-Oxygenated by CYP3A4 and CYP3A5 in Adult Human Liver | 2024 |
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Dr Tarek Abdelghany
Lanyu Fan
Ben Air
Dr Alistair Leitch
Dr Martin Cooke
et al. | Methylimidazolium ionic liquids - A new class of forever chemicals with endocrine disrupting potential | 2024 |
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Shireen Hedya
Adam Charlton
Fahad Aljehani
Khalid Alanazi
Professor Matt Wright
et al. | Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function | 2024 |
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Dr Tarek Mamdouh Abdelghany
Shireen Hedya
Carol De Santis
Dr Jason Gill
Professor Matt Wright
et al. | Potential for cardiac toxicity with methylimidazolium ionic liquids | 2023 |
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Shireen Hedya
Dr Alex Charlton
Dr Alistair Leitch
Fahad Aljehani
Professor Matt Wright
et al. | The methylimidazolium ionic liquid M8OI is a substrate for OCT1 and p-glycoprotein-1 in rat | 2023 |
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Dr Alistair Leitch
Dr Ibrahim Ibrahim
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Clair Roper
et al. | The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver | 2021 |
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Dr Tarek Mamdouh Abdelghany
Dr Alistair Leitch
Professor Peter Blain
Professor Matt Wright
| Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids | 2020 |
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Dr Tarek Mamdouh Abdelghany
Dr Alistair Leitch
Dr Ibrahim Ibrahim
Dr Satomi Miwa
Professor Colin Wilson
et al. | Emerging risk from "environmentally-friendly" solvents: Interaction of methylimidazolium ionic liquids with the mitochondrial electron transport chain is a key initiation event in their mammalian toxicity | 2020 |
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Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Professor Fiona Oakley
Dr Lee Borthwick
et al. | Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse | 2020 |
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Rachel Wilson
Charlotte Candlish
Dr Ibrahim Ibrahim
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
et al. | Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes | 2019 |
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Dr Emma Fairhall
Dr Alistair Leitch
Anne Lakey
Dr Tarek Mamdouh Abdelghany
Dr Ibrahim Ibrahim
et al. | HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell | 2018 |
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Dr Emma Fairhall
Dr Karen Wallace
Steven White
Professor James Shaw
Professor Alastair Burt
et al. | Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research | 2013 |
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