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Browsing publications by Professor Matthew Wright.

Newcastle AuthorsTitleYearFull text
Rodrigo Figueiredo
Dr Avinash Sewpaul
Dr Alistair Leitch
Lucy Bates
Professor Matthew Wright
et al.
Pregnane X Receptor Activation in Liver Perfusion2022
Dr Alistair Leitch
Dr Ibrahim Ibrahim
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Clair Roper
et al.
The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver2021
Dr Tarek Mamdouh Abdelghany
Dr Alistair Leitch
Professor Peter Blain
Professor Matthew Wright
Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids2020
Dr Tarek Mamdouh Abdelghany
Dr Alistair Leitch
Dr Ibrahim Ibrahim
Dr Satomi Miwa
Colin Wilson
et al.
Emerging risk from "environmentally-friendly" solvents: Interaction of methylimidazolium ionic liquids with the mitochondrial electron transport chain is a key initiation event in their mammalian toxicity2020
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Professor Fiona Oakley
Dr Lee Borthwick
et al.
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse2020
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Phillip Probert
Dr Stephanie Meyer
Dr Jeremy Palmer
et al.
The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects2020
Rachel Wilson
Charlotte Candlish
Dr Ibrahim Ibrahim
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
et al.
Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes2019
Professor Matthew Wright
Ionic Liquids: New Emerging Pollutants, Similarities with Perfluorinated Alkyl Substances (PFASs)2019
Dr Aimen Amer
Gourab Sen
Jeremy French
Colin Wilson
Professor Derek Manas
et al.
The association of pregnane X receptor activation with outcomes after liver transplantation—A retrospective study2019
Dr Emma Fairhall
Dr Alistair Leitch
Anne Lakey
Dr Phillip Probert
Carol De Santis
et al.
Glucocorticoid-induced pancreatic-hepatic trans-differentiation in a human cell line in vitro2018
Dr Emma Fairhall
Dr Alistair Leitch
Anne Lakey
Dr Tarek Mamdouh Abdelghany
Dr Ibrahim Ibrahim
et al.
HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell2018
Dr Phillip Probert
Dr Alistair Leitch
Dr Michael Dunn
Dr Stephanie Meyer
Dr Jeremy Palmer
et al.
Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis2018
Dr Alistair Leitch
Anne Lakey
will Hotham
Professor Loranne Agius
Professor George Kass
et al.
The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha2018
Dr Alistair Leitch
Philip Probert
Dr Stephanie Meyer
Professor George Kass
Professor Matthew Wright
et al.
B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals2017
Dr Stephanie Meyer
Dr Phillip Probert
Anne Lakey
Dr Alistair Leitch
Dr Lynsay Blake
et al.
Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes2017
Dr Stephanie Meyer
Dr Phillip Probert
Anne Lakey
Andrew Axon
Dr Alistair Leitch
et al.
Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse2017
Dr Bushra alQuadeib
Professor Lidija Siller
Professor Matthew Wright
Dr Ben Horrocks
Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats2017
Dr Saimir Luli
Dr Stephen Hill
Helen Brown
Jack Leslie
Dr Helen Marshall
et al.
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo2016
Professor Matthew Wright
Hepatic stellate cells regulate liver specific immunity to visceral leishmaniasis through p110δ dependent induction of regulatory T cells in mice2016
Dr Emma Fairhall
Dr Michelle Charles
Dr Phillip Probert
Dr Karen Wallace
Jen Gibb
et al.
Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression2016
Dr Emma Fairhall
Dr Phillip Probert
Professor Fiona Oakley
Professor Matthew Wright
Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system.2016
Dr Phillip Probert
Dr Jeremy Palmer
Dr Aimen Amer
Steven White
Professor David Jones
et al.
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism2016
Aimen Amer
Professor Matthew Wright
Steven White
Activation of the pregnane X receptor (PXR) reduces the risk of early allograft dysfunction following liver transplantation2015
Dr Phillip Probert
Dr Stephanie Meyer
Fouzeyyah Alsaeedi
Andrew Axon
Dr Emma Fairhall
et al.
An expandable donor-free supply of functional hepatocytes for toxicology2015
Dr Saimir Luli
Dr Daniela Di Paolo
Dr Caroline Wilson
Professor Matthew Wright
Helen Brown
et al.
Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice2015
Aimen Amer
Dr Abigail Vallance
Professor Matthew Wright
Steven White
Reducing the risk of early allograft dysfunction in liver transplant recipients by activation of the pregnane x receptor (PXR)2015
Dr Bushra alQuadeib
Professor Lidija Siller
Dr Ben Horrocks
Professor Matthew Wright
Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization2015
Aimen Amer
Dr Phillip Probert
Dr Michael Dunn
Margaret Knight
Dr Abigail Vallance
et al.
Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation2015
Ashleigh McConnell
Dr Graeme O'Boyle
Professor Matthew Wright
Professor Penny Lovat
Targeting mitogen-activated protein kinase kinase to prevent CXCR4-CXCL12 chemotaxis in cutaneous melanoma2015
Dr Phillip Probert
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Jelena Mann
Professor Alastair Burt
et al.
A reversible model for periportal fibrosis and a refined alternative to bile duct ligation2014
Dr Saimir Luli
Dr Stephen Hill
Professor Matthew Wright
Professor Derek Mann
Professor Fiona Oakley
et al.
A simple fluorescence based method to non-invasively image liver fibrosis2014
Dr Emma Fairhall
Dr Karen Wallace
Professor Matthew Wright
Co-culture of B-13 hepatocyte progenitors with liver myofibroblasts promotes progenitor WNT signalling repression in response to glucocorticoids and enhances their transdifferentiation towards hepatocyte-like cells2014
Dr Phillip Probert
Professor Fiona Oakley
Professor Matthew Wright
Improving expression levels of transporters in progenitor-derived hepatocyte-like (B-13/H) cells2014
Dr Phillip Probert
Professor Matthew Wright
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1 ' hydroxyestragole to a genotoxic species - An animal donor-free in vitro screen for phase II activated genotoxins2014
Dr Caroline Wilson
Professor Jelena Mann
Dr Meagan Walsh
Professor Fiona Oakley
Professor Matthew Wright
et al.
Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR32014
Professor Matthew Wright
SMAC mimetics in combination with the pro-inflammatory cytokine TNF alpha augment cell death in B-13 progenitor-derived hepatocytes2014
Dr Jamie Fernandez
Professor Matthew Wright
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription2014
Dr Stephanie Meyer
Andrew Axon
Dr Paul Jowsey
Emeritus Professor Faith Williams
Professor Peter Blain
et al.
Tartrazine is not an activator of the mouse oestrogen ER alpha and ER beta receptors2014
Dr Michelle Charles
Dr Karen Wallace
Dr Phillip Probert
Professor Fiona Oakley
Professor Matthew Wright
et al.
THE glucocorticoid-dependent conversion of the B-13 progenitor cell into hepatocyte-like (B-13/H) cells is dependent on a short exposure to glucocorticoid and epigenetic alterations2014
Dr Bushra alQuadeib
Professor Lidija Siller
Dr Elaine Mutch
Dr Ben Horrocks
Professor Matthew Wright
et al.
Therapeutic monitoring of amphotericin B in Saudi ICU patients using UPLC MS/MS assay2014
Dr Phillip Probert
Git Chung
Dr Simon Cockell
Professor Loranne Agius
Steven White
et al.
Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies2014
Dr Emma Fairhall
Dr Karen Wallace
Steven White
Professor James Shaw
Professor Alastair Burt
et al.
Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research2013
Dr Emma Fairhall
Professor Matthew Wright
Dexamethasone induced hepatic differentiation of rat pancreatic progenitor cells (B-13) in a 3D multicompartment bioreactor system2013
Mohamed Noormohamed
Professor Matthew Wright
Dr David Cowie
Susan Stamp
David Talbot
et al.
Extracorporeal membrane oxygenation for resuscitation of deceased cardiac donor livers for hepatocyte isolation2013
Dr Graeme O'Boyle
Isabella Swidenbank
Dr Helen Marshall
Catriona Barker
Dr Jane Renwick
et al.
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD110702013
Dr Phillip Probert
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
et al.
Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat2013
Dr Emma Fairhall
Dr Michelle Charles
Karen Wallace
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
et al.
The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells.2013
Dr Emma Fairhall
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Dr Karen Wallace
Professor Matthew Wright
et al.
The Hepatic Progenitor B-13 Cell Line Engrafts into the Mouse Liver and Transdifferentiates in Vivo2013
Professor Matthew Wright
Guidance for submission for food additive evaluations2012
Andrew Axon
Dr Felicity May
Dr Luke Gaughan
Professor Faith Williams
Professor Peter Blain
et al.
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity2012
Dr Aimen Amer
Professor Derek Manas
Professor Matthew Wright
Steven White
The effect of hypoxic stress on activated hepatic stellate cell chemotaxis in-vitro2012
Dr Karen Wallace
Professor James Shaw
Professor Alastair Burt
Professor Matthew Wright
Prolonged glucocorticoid exposure results in the appearance of hepatocytes in the adult pancreas2011
Dr Karen Wallace
QUAN LONG
Dr Emma Fairhall
Professor Matthew Wright
Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes2011
Dr Karen Wallace
Emma Fairhall
Professor Matthew Wright
Serum- and glucorticoid-induced kinase 1 (SGK1) plays a key role in the glucocorticoid dependent trans-differentiation of a pancreatic progenitor cell to hepatocytes2011
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Dr Lindsay Murphy
Professor Jelena Mann
Dr Maria Perugorria
et al.
Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease2011
Professor Fiona Oakley
Dr Lindsay Murphy
Professor Matthew Wright
Professor Derek Mann
Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell2011
Elise Andrews
Professor Matthew Wright
Professor Chris Day
Professor Ann Daly
A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury2010
Andy Axon
Dr David Cowie
Professor Fiona Oakley
Professor Faith Williams
Professor Peter Blain
et al.
Acute oestradiol (E2) administration to mice results in liver portal tract inflammation2010
Dr Karen Wallace
Dr Emma Fairhall
Professor Matthew Wright
AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes2010
Professor Matthew Wright
British Toxicology Society Special Reviews 20102010
Steven White
Professor James Shaw
Emeritus Professor Paul Flecknell
Professor Alastair Burt
Professor Matthew Wright
et al.
Chronic elevated systemic glucocorticoid results in widespread pancreatic-hepatic trans-differentiation in vivo2010
Dr Karen Wallace
Professor Matthew Wright
Corrigendum to "Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury" [J Hepatol 49 (2008) 88-98] (DOI:10.1016/j.jhep.2008.01.032)2010
Dr Karen Wallace
Emeritus Professor Paul Flecknell
Professor Alastair Burt
Professor Matthew Wright
Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid2010
Mohamed Noormohamed
Professor Matthew Wright
Dr David Cowie
Susan Stamp
Professor Derek Mann
et al.
Extracorporeal membranous oxygenation in a porcine non-heart beating liver model - a valuable tool for improving hepatocyte viability2010
Mohamed Noormohamed
Dr David Cowie
Steven White
Professor Matthew Wright
Extracorporeal membranous oxygenation in a porcine non-heart beating liver model of organ preservation - A tool for improved hepatocyte isolation2010
Dr Karen Wallace
Dr Carlyn Marek
Professor Matthew Wright
Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling2010
Stephen Hill
Professor Matthew Wright
Hepatic myofibroblasts are pro-inflammatory and activate NF-kappa B in monocytes via a soluble factor2010
Mohamed Noormohamed
Dr David Cowie
Susan Stamp
Professor Derek Manas
Professor Matthew Wright
et al.
Hepatoycte isolation a surrogate for liver transplant- extracorporeal membranous oxygenation a valuable tool for improved hepatocyte viability in a non-heart beating porcine model2010
Professor Matthew Wright
Dr Karen Wallace
Professor James Shaw
Professor Alastair Burt
Steven White
et al.
Long term glucocorticoid therapy leads to pancreatic acinar trans-differentiation into hepatocyte-like cells2010
Dr Mario Abinun
Professor Matthew Wright
Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: Report of 20 novel mutations2010
Dr Helen Marshall
Professor Fiona Oakley
Professor Matthew Wright
Myofibroblast depletion does not inhibit liver regeneration after partial hepatectomy2010
Dr Andrew Douglass
Dr Helen Marshall
Professor Matthew Wright
Myofibroblast depletion during acute CCl4 injury delays hepatocyte injury and promotes liver regeneration2010
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Matthew Wright
Dr Mohammed Ebrahimkhani
et al.
The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation2010
Dr Karen Wallace
Dr David Cowie
Stephen Hill
Andy Axon
Steven White
et al.
The PXR is a drug target for chronic inflammatory liver disease2010
Professor Matthew Wright
The trans-differentiation of pancreatic acinar cells into hepatocytes is mediated by a suppression of WNT signalling2010
Dr Karen Wallace
Professor James Shaw
Professor Alastair Burt
Professor Matthew Wright
Chronic Elevated Systemic Glucocorticocoid Results in Widespread Pancreatic-Hepatic Trans-Differentiation In Vivo2009
Dr Karen Wallace
Dr Carlyn Marek
Professor Matthew Wright
Exocrine pancreas trans-differentiation to hepatocytes-A physiological response to elevated glucocorticoid in vivo2009
Dr Carlyn Marek
Dr Karen Wallace
Professor Matthew Wright
Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics2009
Professor Matthew Wright
Myofibroblast Depletion During Acute CCL4 Injury Delays Hypatocyte Injury and Promotes Liver Regeneration2009
Professor Quentin Anstee
Professor Matthew Wright
Parenchymal extinction: coagulation and hepatic fibrogenesis2009
Dr Karen Wallace
Dr Carlyn Marek
Professor Matthew Wright
The Trans-Differentiation of Pancreatic Acinar Cells into Hepatocytes is Mediated by a Suppression of WNT Signalling Activity2009
Dr David Cowie
Professor Matthew Wright
A functional PXR inhibits portal tract inflammation in a mouse model of cholangiopathy2008
Dr David Cowie
Professor Derek Mann
Professor Matthew Wright
A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?2008
Dr Karen Wallace
Professor Matthew Wright
Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury2008
Dr Andrew Douglass
Dr Karen Wallace
Professor Matthew Wright
C1-3 recombinant antibody targeting myofibroblasts - Specific apoptosis reverses fibrosis in a sustained injury mouse model2008
Professor Derek Mann
Professor Matthew Wright
Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers2008
Professor Quentin Anstee
Professor Matthew Wright
Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies2008
Dr Karen Wallace
Professor Alastair Burt
Professor Matthew Wright
Liver fibrosis2008
Professor Matthew Wright
New technologies for toxicology: Meeting future challenges in drug safety2008
Dr Karen Wallace
Dr David Cowie
Dr Carlyn Marek
Professor Derek Mann
Professor Matthew Wright
et al.
PXR activation reduces hepatic TNF-alpha levels - A mechanism for inhibiting liver fibrosis2008
Elise Andrews
Professor Matthew Wright
Professor Chris Day
Professor Ann Daly
Relevance of PXR to Flucloxacillin-induced Liver Injury2008
Dr Karen Wallace
Professor Muzlifah Haniffa
Professor Matthew Collin
Professor Matthew Wright
Skin Derived Fibroblasts Can Differentiate Into Hepatocyte-Like Cells2008
Dr Karen Wallace
Professor Matthew Wright
Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy2008
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Matthew Wright
Professor Fiona Oakley
et al.
The c-Rel subunit of NF-κB is a regulator of hepatocytes proliferation during recovery from chronic liver injury and regeneration in mice2008
Dr Andrew Douglass
Dr Karen Wallace
Professor Matthew Wright
A human recombinant antibody for targeting anti-fibrogenic therapeutics to myofibroblasts in vivo2007
Dr Carlyn Marek
Dr Karen Wallace
Professor Matthew Wright
Expression of CYP2S1 in human hepatic stellate cells2007
Dr Carlyn Marek
Professor Derek Mann
Professor Matthew Wright
Pregnane X Receptor Activators Inhibit Human Hepatic Stellate Cell Transdifferentiation In Vitro2006
Professor Matthew Wright
The impact of pregnane X receptor activation on liver fibrosis2006
Professor Matthew Wright
Common complications in the chondrodysplasias2005
Professor Matthew Wright
Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics2005
Professor Fiona Oakley
Dr Carlyn Marek
Professor Matthew Wright
Professor Derek Mann
Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis2005
Dr Carlyn Marek
Professor Matthew Wright
Pregnenolone 16α carbonitrile inhibits rodent liver fibrogenesis via PXR-dependent and PXR-independent mechanisms2005
Professor Matthew Wright
Professor Margaret Bassendine
Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: A multicentre randomized controlled trial2005
Professor Matthew Wright
Identification of a truncated ratp28-related protein expressed in kidney2004
Dr Carlyn Marek
Professor Matthew Wright
Mechanism of Action of the Antifibrogenic Compound Gliotoxin in Rat Liver Cells2004
Professor Quentin Anstee
Professor Matthew Wright
The factor V Leiden mutation accelerates disease progression in a mouse model of hepatic fibrosis induced by chronic carbon tetrachloride exposure2004
Dr Carlyn Marek
Professor Matthew Wright
Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro2003
Professor Matthew Wright
Professor Derek Mann
Gliotoxin Stimulates the Apoptosis of Human and Rat Hepatic Stellate Cells and Enhances the Resolution of Liver Fibrosis in Rats2001
Professor Matthew Wright
Professor Derek Mann
Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells2001
Professor Judith Goodship
Dr Miranda Splitt
Professor Matthew Wright
Autozygosity mapping of a Seckel Syndrome Locus to chromosome 3q22.1-q242000
Professor Matthew Wright
Effect of the Adrenal 11-beta Hydroxylase Inhibitor Metyrapone on Human Hepatic Cytochrome P-450 gene Expression: Induction of Cytochrome P-450 3A42000
Professor Matthew Wright
Fibronectin mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin signalled induction of ribonuclease activity2000
Professor Matthew Wright
Mark McAuley
Professor Derek Mann
Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein2000
Professor Matthew Wright
Professor Derek Mann
Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins1999
Dr Ahmed Elsharkawy
Professor Matthew Wright
Professor Derek Mann
Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins1999