Publications by Dr Colin Miles - ePrints

Browsing publications by Dr Colin Miles.

Newcastle Authors	Title	Year
Caroline Dalgliesh Saad Aldalaqan Christian Atallah Dr Andrew Best Dr Emma Scott et al.	An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division	2025
Parmveer Singh Hannah Kendall Laura Wilson Ryan Long Dr Adriana Buskin et al.	Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues	2023
Laura Devlin Miguel Barroso Gil Ruxandra Neatu Laura Powell Dr Emanuela Molinari et al.	Biallelic variants in CEP164 cause a motile ciliopathy-like syndrome	2022
Carina Oliva Laura Powell Dr Ian Wilson Dr Sarah Rice Dr Colin Miles et al.	Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations	2022
Dr Eric Olinger Dr Elisa Molinari Miguel Barroso Gil Laura Powell Dr Colin Miles et al.	A discarded synonymous variant in NPHP3 explains nephronophthisis and congenital hepatic fibrosis in several families	2021
Dan Hayman Dr Tamara Modebadze Sarah Charlton Kat Cheung Dr Jamie Soul et al.	Increased hippocampal excitability in miR-324-null mice	2021
Miguel Barroso Gil Dr Eric Olinger Dr Simon Ramsbottom Dr Elisa Molinari Dr Colin Miles et al.	Update of genetic variants in CEP120 and CC2D2A—With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies	2021
Laura Devlin Dr Simon Ramsbottom Lynne Overman Dr Steven Lisgo Dr Gavin Clowry et al.	Embryonic and foetal expression patterns of the ciliopathy gene CEP164	2020
Laura Powell Miguel Barroso Gil Dr Gavin Clowry Laura Devlin Dr Elisa Molinari et al.	Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development	2020
Sam Charlton Kat Cheung Yao Hao Dr Jamie Soul Dr Louise Reynard et al.	microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs	2020
Dr Simon Ramsbottom Professor Peter Thelwall Dr Katrina Wood Dr Gavin Clowry Laura Devlin et al.	Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome	2020
Dr Elisa Molinari Dr Simon Ramsbottom Dr Shalabh Srivastava Philip Booth Sumaya Alkanderi et al.	Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts	2019
Sumaya Alkanderi Dr Elisa Molinari Veronica Sammut Dr Simon Ramsbottom Dr Shalabh Srivastava et al.	ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition	2018
Dr Elisa Molinari Dr Holly Mabillard Dr Shalabh Srivastava Dr Katrina Wood Sumaya Alkanderi et al.	Human urine-derived renal epithelial cells provide insights into kidney-specific alternate splicing variants	2018
Dr Simon Ramsbottom Dr Elisa Molinari Dr Shalabh Srivastava Sumaya Alkanderi Laura Devlin et al.	Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model	2018
Dr Simon Ramsbottom Dr Elisa Molinari Dr Shalabh Srivastava Sumaya Alkanderi Laura Devlin et al.	Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model	2018
Dr Shalabh Srivastava Dr Simon Ramsbottom Dr Elisa Molinari Sumaya Alkanderi Professor Andrew Filby et al.	A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies	2017
Dr Ann Marie Hynes Dr Shalabh Srivastava Dr Colin Miles Professor John Sayer	DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome	2015
Dr Simon Ramsbottom Dr Colin Miles Professor John Sayer	Murine Cep290 phenotypes are modified by genetic backgrounds and provide an impetus for investigating disease modifier alleles	2015
Dr Shalabh Srivastava Dr Ann Marie Hynes Dr Colin Miles Professor John Sayer	Studying mechanisms underlying cystogenesis in NPHP6 in an ex vivo murine collecting duct cell line	2015
Nouf Al-Ajmi Dr Gabriele Saretzki Dr Colin Miles Professor Ioakim Spyridopoulos	Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbate the ageing phenotype	2014
Dr Ann Marie Hynes Dr Shalabh Srivastava Dr Lorraine Eley Dr Marina Danilenko Professor Peter Thelwall et al.	Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisis	2014
Thomas Cunningham Dr Nicholas Slater Dr Colin Miles	WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio	2013
Dr Colin Miles	Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Krüppel-like zinc-finger protein family and WT1 protein isoforms	2010
Dr Lorraine Eley Dr Roslyn Simms Dr Colin Miles Professor John Sayer	Development of a Novel Murine Model of Nephronophthisis	2009
Dr Anna Wroe Dr Kathryn White Dr Colin Miles	WT1TMT396/+ Mice With Murine Denys-Drash Syndrome Have Reduces VEGF165B Protein with Advancing Disease but Normal Levels Prior to the Onset of Disease	2009
Professor Mark Walker Dr Colin Miles	Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1 tmT396)	2008
Dr Gemma Schofield Dr Colin Miles	In vitro haematopoietic potential of WT1 null murine ES cells	2007
Dr Victor Ruiz-Perez Dr Helen Blair Dr Colin Miles Dr Heiko Peters Professor Judith Goodship et al.	Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia	2007
Dr Andreas Werner Dr Colin Miles Dr Heiko Peters	Expression profiling of antisense transcripts on DNA arrays	2007
Dr Lee Spraggon Dr Colin Miles	hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation	2007
Dr Colin Miles	Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis	2007
Dr Ralf Kist Michelle Watson Paul Cairns Dr Colin Miles Dr Don Reid et al.	Generation of hypomorphic Pax9 mouse mutants as a model for oligodontia in humans	2006
Dr Colin Miles	Gonadal effects of a mouse Denys-Drash Syndrome mutation	2005
Dr Ralf Kist Dr Colin Miles Dr Don Reid Dr Heiko Peters	Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia	2005
Dr Colin Miles	The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression	2004
Dr Colin Miles	Faithful expression of a tagged Fugu WT1 protein from a genomic transgene in zebrafish: efficient splicing of pufferfish genes in zebrafish but not mice	2003
Dr Colin Miles	K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas	2003
Dr Colin Miles Dr Lee Spraggon	Mice Lacking the 68-Amino-Acid, Mammal-Specific N-Terminal Extension of WT1 Develop Normally and Are Fertile	2003
Dr Colin Miles Dr Lee Spraggon	Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis	2003
Dr Colin Miles	Truncation of WT1 results in downregulation of cyclin G1 and IGFBP-4 expression	2001
Dr Colin Miles Dr James Doig	A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome	1999