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Browsing publications by Professor Julie Irving.

Newcastle AuthorsTitleYearFull text
Professor Julie Irving
Paediatric ambiguous lineage leukaemia with monocytic differentiation at diagnosis: case series and review of literature2022
Dr Tobias Menne
Professor Julie Irving
Professor Ruth Plummer
Dr Geoff Shenton
Professor Gareth Veal
et al.
Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial2022
Professor Anthony Moorman
Professor Julie Irving
Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials2021
Dr Amir Enshaei
Dr Sirintra Nakjang
Lynne Minto
Professor Julie Irving
Beth Poole
et al.
The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia2021
Marian Case
Dr Dino Masic
Dr David Jamieson
Dr Frederik van Delft
Dr Andrew Filby
et al.
Label-Free Leukemia Monitoring by Computer Vision2020
Liz Matheson
Huw Thomas
Marian Case
Dr Helen Blair
Rosanna Jackson
et al.
Glucocorticoids and selumetinib are highly synergistic in RAS pathway mutated childhood acute lymphoblastic leukemia through upregulation of BIM2019
Dr Rosanna Jackson
Philip Berry
Julie Errington
Professor Julie Irving
Professor Gareth Veal
et al.
Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia - a report from the UKALL 2011 trial2019
Dr Lina Hamadeh
Professor Julie Irving
Professor Anthony Moorman
Outcomes of patients with childhood B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses: long-term follow-up of the ALLR3 open-label randomised trial2019
Dr Paul Sinclair
Dr Sarra Ryan
Dr Matthew Bashton
Shaun Hollern
Rebecca Hanna
et al.
SH2B3 inactivation through CN-LOH-12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain2019
Professor Julie Irving
Professor Anthony Moorman
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia2018
Jean Norden
Dr Kim Pearce
Professor Julie Irving
Professor Matthew Collin
Professor Anne Dickinson
et al.
The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation2018
Professor Anthony Moorman
Professor Julie Irving
Professor James Allan
Professor Christine Harrison FRCPath FMedSci
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.12017
Dr Britta Vormoor
Professor Gareth Veal
Melanie Griffin
Professor Julie Irving
Lynne Minto
et al.
A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia2017
Zach Dixon
Dr Lindsay Nicholson
Elizabeth Matheson
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
et al.
CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response2017
Professor Julie Irving
Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia2017
Professor Julie Irving
Acute lymphoblastic leukemia in the context of RASopathies2016
Judith Weiland
Dr Deepali Pal
Marian Case
Professor Julie Irving
Dr Frida Ponthan
et al.
BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance2016
Professor Julie Irving
Dr Amir Enshaei
Dr Amy Erhorn
Lynne Minto
Claire Schwab
et al.
Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia2016
Rosanna Jackson
Professor Julie Irving
Professor Gareth Veal
Personalisation of dexamethasone therapy in childhood acute lymphoblastic leukaemia2016
Dr Alex Elder
Dr Klaus Rehe
Dr Simon Bomken
Dr Paul Sinclair
Katie Dormon
et al.
The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.2016
Professor Julie Irving
The Biology, Prognostic Relevance, and Targeted Treatment of Ras Pathway-Positive Childhood Acute Lymphoblastic Leukemia2016
Dr Sarra Ryan
Elizabeth Matheson
Dr Paul Sinclair
Dr Matthew Bashton
Claire Schwab
et al.
The role of the RAS pathway in iAMP21-ALL2016
Professor Julie Irving
Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia2016
Professor Julie Irving
Xenograft-directed personalized therapy for a patient with post-transplant relapse of ALL2016
Professor Julie Irving
Professor Anthony Moorman
Acute Leukemias of Ambiguous Lineage; Study on 247 Pediatric Patients2015
Dr Klaus Rehe
Dr Simon Bomken
Dr Paul Sinclair
Dr Lisa Russell
Professor Olaf Heidenreich
et al.
Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier2015
Professor Anthony Moorman
Professor Julie Irving
Dr Amir Enshaei
Dr Amy Erhorn
Lynne Minto
et al.
Composite Index for Risk Prediction in Relapsed Childhood Acute Lymphoblastic Leukaemia2015
Zach Dixon
Professor Julie Irving
Dr Lindsay Nicholson
Crebbp K nockdown Does Not Impact on Glucocorticoid Induced Apoptosis in Childhood Acute Lymphoblastic Leukemia2015
Zach Dixon
Dr Lindsay Nicholson
Professor Julie Irving
CREBBP Knockdown Does Not Impact on Glucocorticoid Induced Apoptosis in Childhood Acute Lymphoblastic Leukemia2015
Dr Sarah Fordham
Mike Cole
Professor Julie Irving
Professor James Allan
Cytarabine preferentially induces mutation at specific sequences in the genome which are identifiable in relapsed acute myeloid leukaemia2015
Dr Lindsay Nicholson
Dr Emily Mavin
Lynne Minto
Professor Julie Irving
Professor Anne Dickinson
et al.
Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function2015
Dr Lindsay Nicholson
Dr Emily Mavin
Lynne Minto
Professor Julie Irving
Professor Anne Dickinson
et al.
Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function2015
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Christopher Keilty
Maryna Sanichar
et al.
Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition2015
Professor Julie Irving
Elizabeth Matheson
Helen Blair
Marian Case
Isabella Swidenbank
et al.
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood. 2014;124(23):3420-34302015
Professor Anthony Moorman
Professor Julie Irving
Professor James Allan
Professor Christine Harrison FRCPath FMedSci
The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A2015
Dr Jeyanthy Eswaran
Dr Paul Sinclair
Professor Olaf Heidenreich
Professor Julie Irving
Dr Lisa Russell
et al.
The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia2015
Dr Sarah Fordham
Mike Cole
Professor Julie Irving
Professor James Allan
Cytarabine leaves a mutational fingerprint in relapsing leukemia2014
Professor Julie Irving
Elizabeth Matheson
Dr Helen Blair
Marian Case
Isabella Swidenbank
et al.
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition2014
Dr Thomas Knight
Professor Julie Irving
Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting2014
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Dr Daniel Williamson
Professor Julie Irving
et al.
Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations2013
Professor Graham Jackson
Professor Julie Irving
Professor James Allan
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk2013
Professor Julie Irving
Professor James Allan
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype2013
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Marian Case
Maryna Sanichar
et al.
Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia2012
Professor Julie Irving
Professor James Allan
Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia2012
Professor Julie Irving
Detection and monitoring of normal and leukemic cell populations with hierarchical clustering of flow cytometry data2012
Dr Jill Hunter
Dr Elaine Willmore
Professor Julie Irving
Dr Stephany Veuger
Professor barbara Durkacz
et al.
NF-kappa B mediates radio-sensitization by the PARP-1 inhibitor, AG-0146992012
Michael Batey
Dr Yan Zhao
Dr Helen Maitland
Professor Hing Leung
Dr Andrew Hall
et al.
Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma2011
Professor Julie Irving
Professor James Allan
DNA mismatch repair status affects cellular response to Ara-C and other anti-leukemic nucleoside analogs2011
Dr Vikki Rand
Dr Lisa Russell
Claire Schwab
Hannah Ensor
Professor Julie Irving
et al.
Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia2011
Haya AL-Balool
Dr Mark Wade
Dr Jonathan Coxhead
Professor Julie Irving
Professor David Elliott
et al.
Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant2011
Michael Batey
Professor Julie Irving
Professor Herbie Newell
Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models2011
Dr Lindsay Nicholson
Charlotte Evans
Elizabeth Matheson
Lynne Minto
Christopher Keilty
et al.
Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target2011
Dr Sarra Ryan
Dr Vikki Rand
Claire Schwab
Heather Morrison
Elizabeth Matheson
et al.
Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients2011
Professor Graham Jackson
Dr Nicola Sunter
Dr Andrew Hall
Professor Julie Irving
Professor James Allan
et al.
A polymorphism in the 3' UTR of IRF4 linked to susceptibility and pathogenesis in chronic lymphocytic leukaemia and Hodgkin lymphoma has limited impact in multiple myeloma2010
Dr Amy Peasland
Elizabeth Matheson
Dr Andrew Hall
Professor Julie Irving
Alternative splicing of hMLH1 in childhood acute lymphoblastic leukaemia and characterisation of the variably expressed Δ9/10 isoform as a dominant negative species2010
Professor Julie Irving
Analysis of BCR ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype2010
Professor Julie Irving
Analysis of BCR-ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype2010
Professor Stephen O'Brien
Professor Julie Irving
Analysis of BCR-ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype2010
Professor Julie Irving
Professor James Allan
Cellular Response to Cytarabine Is Modulated by the DNA Mismatch Repair Pathway: Implications for Treatment of Acute Myeloid Leukemia2010
Dr Sarah Fordham
Emeritus Professor Keith Scott
Professor Julie Irving
Professor James Allan
Cellular Response to Cytarabine is Modulated by the DNA Mismatch Repair Pathway: Implications for Treatment of Acute Myeloid Leukemia2010
Professor Julie Irving
Professor James Allan
Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk2010
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Hesta McNeill
Professor Julie Irving
et al.
In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous2010
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Hesta McNeill
Professor Julie Irving
et al.
In Acute Lymphoblastic Leukaemia, Sternness Is Frequent and Ubiquitous2010
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Hesta McNeill
Professor Julie Irving
et al.
In acute lymphoblastic leukemia, stemness is frequent and ubiquitous2010
Dr Klaus Rehe
Kerrie Wilson
Hesta McNeill
Professor Julie Irving
Professor Hermann Josef Vormoor
et al.
In standard and high risk acute lymphoblastic leukemias disease propagating cells are abundant and not confined to certain immunophenotypic fractions2010
Professor Julie Irving
Professor James Allan
MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukaemia2010
Elizabeth Matheson
Lynne Minto
Dr Andrew Hall
Professor Julie Irving
Mismatch repair and the downstream target genes, PAX5 and Ikaros, in childhood acute lymphoblastic leukemia2010
Dr Lindsay Nicholson
Dr Andrew Hall
Dr Chris Redfern
Professor Julie Irving
NF kappa B modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia2010
Professor Julie Irving
Professor James Allan
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk2010
Sarina Sulong
Professor Anthony Moorman
Professor Julie Irving
Marian Case
Professor Simon Bailey
et al.
A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups2009
Dr Lisa Russell
Professor Olaf Heidenreich
Professor Julie Irving
Professor Anthony Moorman
Heather Morrison
et al.
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia2009
Professor Julie Irving
Marian Case
Lynne Minto
Sally Lawson
Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting2009
Kate Wilson
Marian Case
Lynne Minto
Professor Simon Bailey
Dr Nicholas Bown
et al.
Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhoood acute lymphoblastic leukemia2009
Professor Julie Irving
Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis2009
Professor Julie Irving
Professor James Allan
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia2009
Professor Anthony Moorman
Dr Michael Griffiths
Professor Julie Irving
Professor Christine Harrison FRCPath FMedSci
Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia2009
Nicola Brown
Professor Julie Irving
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells2009
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Christopher Keilty
Dr Andrew Hall
et al.
Quantitative Proteomic Analysis Implicates An Altered B-Cell Differentiation State as a Mechanism Underlying GC-Resistance in An Acute Lymphoblastic Leukaemia (ALL) Cell Line Model2009
Dr Vikki Rand
Dr Lisa Russell
Professor Julie Irving
Lisa Jones
Dr Dino Masic
et al.
What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?2009
Dr Akheel Syed
Dr Christina Halpin
Professor Julie Irving
Professor Nigel Unwin
Professor Martin White
et al.
A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men2008
Michael Batey
Dr Amy Peasland
Professor Julie Irving
Professor Herbie Newell
Development of inhibitors of the fibroblast growth factor receptor (FGFR) kinase using a fragment based approach2008
Professor Julie Irving
Lynne Minto
Dr Andrew Hall
Genomic analysis of different clonal evolution in a twin pair with t(12;21) positive acute lymphoblastic leukemia sharing the same prenatal clone [8]2008
Elizabeth Matheson
Lynne Minto
Professor Anthony Moorman
Dr Andrew Hall
Professor Julie Irving
et al.
Heterogeneous breakpoints target PAX5 in acute lymphoblastic leukaemia patients with dicentric chromosomes2008
Dr Simon Bomken
Kerrie Wilson
Professor Julie Irving
Professor Hermann Josef Vormoor
In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties2008
Kerrie Wilson
Dr Klaus Rehe
Dr Simon Bomken
Marian Case
Professor Julie Irving
et al.
In Childhood ALL, Both Blasts with a CD20(-/Low) and a CD20(High) Immunophenotype, Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y-/- Mice2008
Michael Batey
Dr Helen Maitland
Professor Hing Leung
Dr Andrew Hall
Professor Graham Jackson
et al.
In vitro activity of the multi targeted receptor tyrosine kinase inhibitor sunitinib against multiple myeloma cell lines is not predictive of in vivo xenograft response2008
Professor Anthony Moorman
Sarina Sulong
Professor Julie Irving
Marian Case
Lynne Minto
et al.
Inactivation of CDKN2A in childhood acute lymphoblastic leukaemia (ALL) occurs principally by deletion and is strongly correlated with cytogenetic subgroups2008
Dr Karel Fiser
Professor Julie Irving
Professor Hermann Josef Vormoor
MRD Monitoring of Childhood ALL Using Hierarchical Clustering and Support Vector Machine Learning of Complex Multi-Parameter Flow Cytometry Data2008
Marian Case
Elizabeth Matheson
Lynne Minto
Dr Nicholas Bown
Professor Simon Bailey
et al.
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia2008
Marian Case
Elizabeth Matheson
Lynne Minto
Professor Christine Harrison FRCPath FMedSci
Dr Nicholas Bown
et al.
Somatic mutation of genes impacting on the RAS-RAF-MEK-ERK pathway is the most common genetic abnormality in childhood acute lymphoblastic leukaemia, is implicated in disease progression and provides a rationale for therapeutic targeting2008
Kerrie Wilson
Marian Case
Lynne Minto
Professor Simon Bailey
Professor Hermann Josef Vormoor
et al.
The CD34+ CD38Low CD19+ Candidate Leukemic Stem Cell Phenotype Revisited: Useful for Flow MRD Monitoring?2008
Marian Case
Dr Tina Davies
Professor Anthony Moorman
Dr Andrew Hall
Professor Julie Irving
et al.
The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR12008
Elizabeth Matheson
Professor Anthony Moorman
Dr Andrew Hall
Professor Christine Harrison FRCPath FMedSci
Professor Julie Irving
et al.
Variable breakpoints target PAX5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer2008
Elizabeth Matheson
Dr Linda Hogarth
Marian Case
Professor Julie Irving
Dr Andrew Hall
et al.
DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo2007
Professor Anthony Moorman
Marian Case
Professor Julie Irving
Dr Andrew Hall
Professor Christine Harrison FRCPath FMedSci
et al.
Genomic profiling reveals multiple genetic targets in ETV6-RUNX1 positive acute lymphoblastic leukaemia (ALL)2007
Adillah Binti Yusof
Professor Julie Irving
Marian Case
Lynne Minto
Professor Christine Harrison FRCPath FMedSci
et al.
Red blood cell alloimmunization is affected by depletion of donor white cell subsets2007
Elizabeth Matheson
Lynne Minto
Professor Anthony Moorman
Dr Andrew Hall
Professor Julie Irving
et al.
Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer2007
Dr Andrew Hall
Sarina Sulong
Professor Christine Harrison FRCPath FMedSci
Lynne Minto
Dr Nicholas Bown
et al.
Assessment of aneuploidy in childhood acute lymphoblastic leukaemia using high density oligonucleotide arrays.2006
Dr Akheel Syed
Professor Julie Irving
Dr Chris Redfern
Dr Andrew Hall
Professor Nigel Unwin
et al.
Association of glucocorticoid receptor polymorphism A3669G in exon 9β with reduced central adiposity in women2006
Sarina Sulong
Professor Julie Irving
Marian Case
Lynne Minto
Dr Nicholas Bown
et al.
Comprehensive analysis of p16(INK4a) in childhood acute lymphoblastic leukemia reveals homozygous deletion, haploinsufficiency and acquired isodisomy at the 9p locus with intact p16(INK4a).2006
Professor Julie Irving
Lynne Minto
Elizabeth Matheson
Dr Lindsay Nicholson
Dr Andrew Hall
et al.
Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor2006
Professor Julie Irving
Lynne Minto
Elizabeth Matheson
Marian Case
Professor Simon Bailey
et al.
Mutation in genes impacting on the RAS-RAF-MEK-ERK pathway are found at high incidence in childhood acute lymphoblastic leukemia at both diagnosis and at relapse.2006
Dr Andrew Hall
Professor Julie Irving
Lynne Minto
Reply to 'ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia' by Gumy-Pause et al. [6]2006
Professor Julie Irving
Dr Andrew Hall
Constitutional segmental uniparental disomy in a twin pair with t(12;21) positive acute lymphoblastic leukemia characterized by the same prenatal clone and divergent clonal evolution2005
Dr Mark Velangi
Elizabeth Matheson
Dr Andrew Hall
Professor Julie Irving
Detecting mismatch repair defects in myeloma2005
Professor Julie Irving
Lynne Minto
Professor Simon Bailey
Dr Andrew Hall
Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course2005
Professor Julie Irving
Clare Bloodworth
Dr Nicholas Bown
Marian Case
Dr Linda Hogarth
et al.
Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis2005
Dr Andrew Hall
Professor Julie Irving
Lynne Minto
Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia2005
Sarina Sulong
Marian Case
Lynne Minto
Dr Bridget Wilkins
Dr Andrew Hall
et al.
The V617F mutation in Jak2 is not found in childhood acute lymphoblastic leukaemia2005
Dr Mark Velangi
Elizabeth Matheson
Dr Penelope Taylor
Professor Graham Jackson
Dr Andrew Hall
et al.
BRAF gene is not mutated in mismatch repair-proficient or -deficient plasma cell dyscrasias 2004
Dr Mark Velangi
Elizabeth Matheson
Professor Graham Jackson
Dr Penelope Taylor
Dr Andrew Hall
et al.
DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma2004
Dr Andrew Hall
Professor Julie Irving
Lynne Minto
Genetic variants of ataxia telangiectasia mutated (ATM) and susceptibility for childhood T-lineage acute lymphoblastic leukemia.2004
Dr Andrew Hall
Clare Bloodworth
Dr Linda Hogarth
Dr Nicholas Bown
Professor Julie Irving
et al.
Loss of heterozygosity in childhood acute lymphoblastic leukaemia detected by genome-wide microarray single nucleotide polymorphism analysis2004
Dr Akheel Syed
Professor Julie Irving
Dr Chris Redfern
Dr Andrew Hall
Professor Nigel Unwin
et al.
Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom2004
Professor Julie Irving
Professor Stephen O'Brien
Dr Anne Lennard
Lynne Minto
Dr Feng Lin
et al.
Use of Denaturing HPLC for Detection of Mutations in the BCR-ABL Kinase Domain in Patients Resistant to Imatinib2004
Dr Mark Velangi
Professor Graham Jackson
Dr Penelope Taylor
Dr Andrew Hall
Professor Julie Irving
et al.
DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma2003
Dr Andrew Hall
Dr Sally Coulthard
Professor Julie Irving
Molecular diagnostics: a healthcare perspective2003
Professor Julie Irving
Professor Stephen O'Brien
Dr Anne Lennard
Dr Feng Lin
Dr Andrew Hall
et al.
The use of denaturing high-performance liquid chromatography (DHPLC) for the detection of mutations in the bcr-abl oncogene in patients resistant to imatinib2003
Diana Levett
Dr Andrew Hall
Dr John Hanley
Professor Julie Irving
Comparitive study of conformation sensitive gel electrophoresis (CSGE) and denaturing high pressure liquid chromatography (DHPLC) for mutation detection in von Willebrands disease2002
Dr Andrew Hall
Professor Julie Irving
New drugs, new drug resistance mechanisms2002
Professor Julie Irving
Dr Andrew Hall
Mismatch repair defects as a cause of resistance to cytotoxic drugs2001
Professor Julie Irving
Dr Penelope Taylor
Professor Graham Jackson
Dr Andrew Hall
The presence of mismatch repair defects in plasma cell dyscrasias2001
Professor Julie Irving
Dr Anne Lennard
Professor Stephen Proctor
Dr Penelope Taylor
Validation of the Hasford score in a demographic study in chronic granulocytic leukaemia2001
Dr Peter Middleton
Jean Norden
Diana Levett
Dr Mark Levasseur
Professor Julie Irving
et al.
Population-based study of the pattern of molecular markers of minimal residual disease in childhood and adult acute lymphoblastic leukemia: An assessment of the practical difficulty of representative sampling for trial purposes2000
Professor Julie Irving
Gerard Cain
Dr Brian Angus
Dr Penelope Taylor
The role of alternative splicing of the adhesion molecule, CD44, in lymphoid malignancy1998
Professor Julie Irving
Dr Anne Lennard
Professor Anne Dickinson
Philadelphia evaluations of CD34 populations in chronic granulocytic leukaemia; A comparison of bone marrow and peripheral blood stem cell harvests.1997
Professor Julie Irving
Gerard Cain
Dr Brian Angus
The role of alternative splicing of the adhesion molecule, CD44 in lymphoid malignancy1997
Professor Julie Irving
Gerard Cain
Dr Brian Angus
OCT embedded sections of pathological specimens as a source of high quality RNA for reverse transcriptase/polymerase chain reaction1996
Professor Julie Irving
Professor Stephen Proctor
Professor Graham Jackson
Basophilia, t(15;17) translocation and atypical AML1995
Professor Julie Irving
A simple, reproducible and cheap batch method for the analysis of serum glycoproteins using sepharose-coupled lectins and silver staining1987