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Browsing publications by Lynne Minto.

Newcastle AuthorsTitleYearFull text
Dr Amir Enshaei
Dr Sirintra Nakjang
Lynne Minto
Professor Julie Irving
Beth Poole
et al.
The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia2021
Dr Britta Vormoor
Professor Gareth Veal
Melanie Griffin
Professor Julie Irving
Lynne Minto
et al.
A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia2017
Professor Julie Irving
Dr Amir Enshaei
Dr Amy Erhorn
Lynne Minto
Claire Schwab
et al.
Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia2016
Dr Sarra Ryan
Elizabeth Matheson
Dr Paul Sinclair
Dr Matthew Bashton
Claire Schwab
et al.
The role of the RAS pathway in iAMP21-ALL2016
Professor Anthony Moorman
Professor Julie Irving
Dr Amir Enshaei
Dr Amy Erhorn
Lynne Minto
et al.
Composite Index for Risk Prediction in Relapsed Childhood Acute Lymphoblastic Leukaemia2015
Dr Lindsay Nicholson
Dr Emily Mavin
Lynne Minto
Professor Julie Irving
Professor Anne Dickinson
et al.
Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function2015
Dr Lindsay Nicholson
Dr Emily Mavin
Lynne Minto
Professor Julie Irving
Professor Anne Dickinson
et al.
Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function2015
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Christopher Keilty
Maryna Sanichar
et al.
Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition2015
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Marian Case
Maryna Sanichar
et al.
Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia2012
Dr Vikki Rand
Dr Lisa Russell
Claire Schwab
Hannah Ensor
Professor Julie Irving
et al.
Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia2011
Dr Lindsay Nicholson
Charlotte Evans
Elizabeth Matheson
Lynne Minto
Christopher Keilty
et al.
Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target2011
Dr Sarra Ryan
Dr Vikki Rand
Claire Schwab
Heather Morrison
Elizabeth Matheson
et al.
Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients2011
Elizabeth Matheson
Lynne Minto
Emeritus Professor Andy Hall
Professor Julie Irving
Mismatch repair and the downstream target genes, PAX5 and Ikaros, in childhood acute lymphoblastic leukemia2010
Professor Julie Irving
Marian Case
Lynne Minto
Sally Lawson
Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting2009
Kate Wilson
Marian Case
Lynne Minto
Professor Simon Bailey
Dr Nicholas Bown
et al.
Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhoood acute lymphoblastic leukemia2009
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Christopher Keilty
Emeritus Professor Andy Hall
et al.
Quantitative Proteomic Analysis Implicates An Altered B-Cell Differentiation State as a Mechanism Underlying GC-Resistance in An Acute Lymphoblastic Leukaemia (ALL) Cell Line Model2009
Dr Vikki Rand
Dr Lisa Russell
Professor Julie Irving
Lisa Jones
Dr Dino Masic
et al.
What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?2009
Professor Julie Irving
Lynne Minto
Emeritus Professor Andy Hall
Genomic analysis of different clonal evolution in a twin pair with t(12;21) positive acute lymphoblastic leukemia sharing the same prenatal clone [8]2008
Elizabeth Matheson
Lynne Minto
Professor Anthony Moorman
Emeritus Professor Andy Hall
Professor Julie Irving
et al.
Heterogeneous breakpoints target PAX5 in acute lymphoblastic leukaemia patients with dicentric chromosomes2008
Professor Anthony Moorman
Sarina Sulong
Professor Julie Irving
Marian Case
Lynne Minto
et al.
Inactivation of CDKN2A in childhood acute lymphoblastic leukaemia (ALL) occurs principally by deletion and is strongly correlated with cytogenetic subgroups2008
Marian Case
Elizabeth Matheson
Lynne Minto
Dr Nicholas Bown
Professor Simon Bailey
et al.
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia2008
Marian Case
Elizabeth Matheson
Lynne Minto
Professor Christine Harrison FRCPath FMedSci
Dr Nicholas Bown
et al.
Somatic mutation of genes impacting on the RAS-RAF-MEK-ERK pathway is the most common genetic abnormality in childhood acute lymphoblastic leukaemia, is implicated in disease progression and provides a rationale for therapeutic targeting2008
Kerrie Wilson
Marian Case
Lynne Minto
Professor Simon Bailey
Professor Hermann Josef Vormoor
et al.
The CD34+ CD38Low CD19+ Candidate Leukemic Stem Cell Phenotype Revisited: Useful for Flow MRD Monitoring?2008
Adillah Binti Yusof
Professor Julie Irving
Marian Case
Lynne Minto
Professor Christine Harrison FRCPath FMedSci
et al.
Red blood cell alloimmunization is affected by depletion of donor white cell subsets2007
Elizabeth Matheson
Lynne Minto
Professor Anthony Moorman
Emeritus Professor Andy Hall
Professor Julie Irving
et al.
Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer2007
Emeritus Professor Andy Hall
Sarina Sulong
Professor Christine Harrison FRCPath FMedSci
Lynne Minto
Dr Nicholas Bown
et al.
Assessment of aneuploidy in childhood acute lymphoblastic leukaemia using high density oligonucleotide arrays.2006
Sarina Sulong
Professor Julie Irving
Marian Case
Lynne Minto
Dr Nicholas Bown
et al.
Comprehensive analysis of p16(INK4a) in childhood acute lymphoblastic leukemia reveals homozygous deletion, haploinsufficiency and acquired isodisomy at the 9p locus with intact p16(INK4a).2006
Professor Julie Irving
Lynne Minto
Elizabeth Matheson
Dr Lindsay Nicholson
Emeritus Professor Andy Hall
et al.
Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor2006
Professor Julie Irving
Lynne Minto
Elizabeth Matheson
Marian Case
Professor Simon Bailey
et al.
Mutation in genes impacting on the RAS-RAF-MEK-ERK pathway are found at high incidence in childhood acute lymphoblastic leukemia at both diagnosis and at relapse.2006
Emeritus Professor Andy Hall
Professor Julie Irving
Lynne Minto
Reply to 'ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia' by Gumy-Pause et al. [6]2006
Professor Julie Irving
Lynne Minto
Professor Simon Bailey
Emeritus Professor Andy Hall
Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course2005
Monique Lhussier
Lynne Minto
Paradoxes, locations and the need for social coherence: a qualitative study of living with a learning difficulty2005
Emeritus Professor Andy Hall
Professor Julie Irving
Lynne Minto
Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia2005
Sarina Sulong
Marian Case
Lynne Minto
Dr Bridget Wilkins
Emeritus Professor Andy Hall
et al.
The V617F mutation in Jak2 is not found in childhood acute lymphoblastic leukaemia2005
Dr Sandeep Pal
Lynne Minto
Emeritus Professor Andy Hall
Antibodies against 9-O-acetylated sialoglycans: A potent marker to monitor clinical status in childhood acute lymphoblastic leukemia2004
Emeritus Professor Andy Hall
Professor Julie Irving
Lynne Minto
Genetic variants of ataxia telangiectasia mutated (ATM) and susceptibility for childhood T-lineage acute lymphoblastic leukemia.2004
Professor Julie Irving
Professor Stephen O'Brien
Dr Anne Lennard
Lynne Minto
Dr Feng Lin
et al.
Use of Denaturing HPLC for Detection of Mutations in the BCR-ABL Kinase Domain in Patients Resistant to Imatinib2004
Dr Sally Coulthard
Dr Linda Hogarth
Dr Margaret Little
Elizabeth Matheson
Dr Chris Redfern
et al.
The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs2002
Dr Linda Hogarth
Lynne Minto
Enhanced expression and activity of DNA polymerase β in human ovarian tumor cells: impact on sensitivity towards antitumor agents2001
Dr Linda Hogarth
Dr Margaret Little
Lynne Minto
Dr Chris Redfern
Emeritus Professor Andy Hall
et al.
High thiopurine methyltransferase expression confers different levels of resistance with 6-thioguanine compared to 6-mercaptopurine.2001
Dr Linda Hogarth
Dr Margaret Little
Lynne Minto
Dr Chris Redfern
Emeritus Professor Andy Hall
et al.
In vitro evidence for differences in 6-mercaptopurine versus 6-thioguanine metabolism depending on TPMT status2001
Emeritus Professor Andy Hall
Dr Peter Hamilton
Lynne Minto
Dr Sally Coulthard
The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase2001
Dr Sally Coulthard
Dr Christopher Howell
Lynne Minto
Dr Peter Middleton
Professor Graham Jackson
et al.
A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations2000
Dr Sally Coulthard
Dr Linda Hogarth
Lynne Minto
Dr Chris Redfern
Emeritus Professor Andy Hall
et al.
High thiopurine methyltransferase expression confers different levels of resistance with 6-thioguanine compared to 6-mercaptopurine2000
Dr Linda Hogarth
Elizabeth Matheson
Lynne Minto
Dr Margaret Little
Emeritus Professor Andy Hall
et al.
Measurement of resistance to thiopurine drugs in cells with defective mismatch repair2000